FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1960196841> ?p ?o ?g. }

• W1960196841 endingPage "644" @default.
• W1960196841 startingPage "634" @default.
• W1960196841 abstract "Hypoxia leads to the stabilisation of the hypoxia-inducible factor (HIF) transcription factor that drives the expression of target genes including microRNAs (miRNAs). MicroRNAs are known to regulate many genes involved in tumourigenesis. The aim of this study was to identify hypoxia-regulated miRNAs (HRMs) in bladder cancer and investigate their functional significance.Bladder cancer cell lines were exposed to normoxic and hypoxic conditions and interrogated for the expression of 384 miRNAs by qPCR. Functional studies were carried out using siRNA-mediated gene knockdown and chromatin immunoprecipitations. Apoptosis was quantified by annexin V staining and flow cytometry.The HRM signature for NMI bladder cancer lines includes miR-210, miR-193b, miR-145, miR-125-3p, miR-708 and miR-517a. The most hypoxia-upregulated miRNA was miR-145. The miR-145 was a direct target of HIF-1α and two hypoxia response elements were identified within the promoter region of the gene. Finally, the hypoxic upregulation of miR-145 contributed to increased apoptosis in RT4 cells.We have demonstrated the hypoxic regulation of a number of miRNAs in bladder cancer. We have shown that miR-145 is a novel, robust and direct HIF target gene that in turn leads to increased cell death in NMI bladder cancer cell lines." @default.
• W1960196841 created "2016-06-24" @default.
• W1960196841 creator A5009860818 @default.
• W1960196841 creator A5021892034 @default.
• W1960196841 creator A5032231578 @default.
• W1960196841 creator A5074702285 @default.
• W1960196841 creator A5079633934 @default.
• W1960196841 creator A5090492406 @default.
• W1960196841 creator A5091328614 @default.
• W1960196841 date "2015-07-21" @default.
• W1960196841 modified "2023-10-11" @default.
• W1960196841 title "Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis" @default.
• W1960196841 cites W1578339880 @default.
• W1960196841 cites W1580865462 @default.
• W1960196841 cites W1924097582 @default.
• W1960196841 cites W1964631913 @default.
• W1960196841 cites W1979912448 @default.
• W1960196841 cites W2015136692 @default.
• W1960196841 cites W2018723470 @default.
• W1960196841 cites W2019571961 @default.
• W1960196841 cites W2025635382 @default.
• W1960196841 cites W2036534625 @default.
• W1960196841 cites W2039164708 @default.
• W1960196841 cites W2039500562 @default.
• W1960196841 cites W2049108030 @default.
• W1960196841 cites W2053555736 @default.
• W1960196841 cites W2067053182 @default.
• W1960196841 cites W2069759108 @default.
• W1960196841 cites W2072674349 @default.
• W1960196841 cites W2073118251 @default.
• W1960196841 cites W2074629894 @default.
• W1960196841 cites W2076439746 @default.
• W1960196841 cites W2088161934 @default.
• W1960196841 cites W2096785399 @default.
• W1960196841 cites W2099692224 @default.
• W1960196841 cites W2106958499 @default.
• W1960196841 cites W2107277218 @default.
• W1960196841 cites W2109155259 @default.
• W1960196841 cites W2110014787 @default.
• W1960196841 cites W2111783800 @default.
• W1960196841 cites W2113262768 @default.
• W1960196841 cites W2114047398 @default.
• W1960196841 cites W2114557056 @default.
• W1960196841 cites W2116000203 @default.
• W1960196841 cites W2120129511 @default.
• W1960196841 cites W2121164913 @default.
• W1960196841 cites W2127681799 @default.
• W1960196841 cites W2131278139 @default.
• W1960196841 cites W2131872235 @default.
• W1960196841 cites W2135810600 @default.
• W1960196841 cites W2136757828 @default.
• W1960196841 cites W2138368916 @default.
• W1960196841 cites W2138518792 @default.
• W1960196841 cites W2145403987 @default.
• W1960196841 cites W2152455106 @default.
• W1960196841 cites W2153550523 @default.
• W1960196841 cites W2158635438 @default.
• W1960196841 cites W2162097274 @default.
• W1960196841 cites W2163032823 @default.
• W1960196841 cites W2163652992 @default.
• W1960196841 cites W3150647820 @default.
• W1960196841 doi "https://doi.org/10.1038/bjc.2015.203" @default.
• W1960196841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4647685" @default.
• W1960196841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26196183" @default.
• W1960196841 hasPublicationYear "2015" @default.
• W1960196841 type Work @default.
• W1960196841 sameAs 1960196841 @default.
• W1960196841 citedByCount "69" @default.
• W1960196841 countsByYear W19601968412015 @default.
• W1960196841 countsByYear W19601968412016 @default.
• W1960196841 countsByYear W19601968412017 @default.
• W1960196841 countsByYear W19601968412018 @default.
• W1960196841 countsByYear W19601968412019 @default.
• W1960196841 countsByYear W19601968412020 @default.
• W1960196841 countsByYear W19601968412021 @default.
• W1960196841 countsByYear W19601968412022 @default.
• W1960196841 countsByYear W19601968412023 @default.
• W1960196841 crossrefType "journal-article" @default.
• W1960196841 hasAuthorship W1960196841A5009860818 @default.
• W1960196841 hasAuthorship W1960196841A5021892034 @default.
• W1960196841 hasAuthorship W1960196841A5032231578 @default.
• W1960196841 hasAuthorship W1960196841A5074702285 @default.
• W1960196841 hasAuthorship W1960196841A5079633934 @default.
• W1960196841 hasAuthorship W1960196841A5090492406 @default.
• W1960196841 hasAuthorship W1960196841A5091328614 @default.
• W1960196841 hasBestOaLocation W19601968411 @default.
• W1960196841 hasConcept C104317684 @default.
• W1960196841 hasConcept C121608353 @default.
• W1960196841 hasConcept C127561419 @default.
• W1960196841 hasConcept C145059251 @default.
• W1960196841 hasConcept C150194340 @default.
• W1960196841 hasConcept C153911025 @default.
• W1960196841 hasConcept C160450060 @default.
• W1960196841 hasConcept C165864922 @default.
• W1960196841 hasConcept C173396325 @default.
• W1960196841 hasConcept C178790620 @default.
• W1960196841 hasConcept C185592680 @default.
• W1960196841 hasConcept C190283241 @default.

• next