FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1960200240> ?p ?o ?g. }

• W1960200240 abstract "Adult endothelial progenitor cells (EPCs) reduce myocardial infarct size and improve postischemic myocardial function. We have recently shown that clonal embryonic EPCs (eEPCs), derived from 7.5-day-old mice, home specifically to hypoxic areas in tumor metastasis mouse models but spare normal organs and do not form carcinomas. Here, we assessed the potential of eEPCs to limit organ dysfunction after ischemia and reperfusion in a preclinical pig model.Pigs were subjected to ischemia (60-minute left anterior descending [LAD] artery occlusion) and reperfusion (7 days). At the end of ischemia, we applied medium with or without 5 x 10(6) eEPCs by either pressure-regulated retroinfusion or intravenous transfusion. One hour after reperfusion, 99Tc-labeled eEPCs engrafted to a 6-fold higher extent in the ischemic myocardium after retroinfusion than after intravenous application. Regional myocardial function (subendocardial segment shortening [SES] at 150/min, given in percent of nonischemic circumflex region) and infarct size (TTC viability and Methylene-blue exclusion) were determined 24 hours and 7 days later. Compared with medium-treated animals, retroinfusion of eEPCs decreased infarct size (35+/-4% versus 51+/-6%) and improved regional myocardial reserve of the apical LAD region (SES 31+/-4% versus 6+/-8%), whereas intravenous application displayed a less pronounced effect (infarct size 44+/-4%; SES 12+/-3%). Retroinfusion of an equal amount of neonatal coronary endothelial cells (rat) did not affect infarct size (49+/-5%) nor regional myocardial reserve (16+/-7%). The eEPC-dependent effect was detected at 24 hours of reperfusion (infarct size 34+/-7% versus 58+/-6%) and was sensitive to Wortmannin coapplication (50+/-5%).Our findings show that eEPCs reduce ischemia-reperfusion injury in a preclinical pig model. The rapid effect (as early as 24 hours) indicates a role for enzyme-mediated cardioprotection, which involves, at least in part, the phosphatidylinositol 3-kinase/AKT pathway." @default.
• W1960200240 created "2016-06-24" @default.
• W1960200240 creator A5000406175 @default.
• W1960200240 creator A5003364544 @default.
• W1960200240 creator A5016552031 @default.
• W1960200240 creator A5027420105 @default.
• W1960200240 creator A5042700458 @default.
• W1960200240 creator A5045094613 @default.
• W1960200240 creator A5056456336 @default.
• W1960200240 creator A5057857925 @default.
• W1960200240 creator A5059321865 @default.
• W1960200240 creator A5064539315 @default.
• W1960200240 creator A5065500721 @default.
• W1960200240 creator A5069532486 @default.
• W1960200240 creator A5073971504 @default.
• W1960200240 date "2005-08-30" @default.
• W1960200240 modified "2023-10-16" @default.
• W1960200240 title "Retroinfusion of Embryonic Endothelial Progenitor Cells Attenuates Ischemia-Reperfusion Injury in Pigs" @default.
• W1960200240 cites W1927240777 @default.
• W1960200240 cites W1971444570 @default.
• W1960200240 cites W1978859651 @default.
• W1960200240 cites W1992290627 @default.
• W1960200240 cites W1994136666 @default.
• W1960200240 cites W2008747758 @default.
• W1960200240 cites W2010861038 @default.
• W1960200240 cites W2032554944 @default.
• W1960200240 cites W2034293734 @default.
• W1960200240 cites W2050744280 @default.
• W1960200240 cites W2056511195 @default.
• W1960200240 cites W2056905507 @default.
• W1960200240 cites W2098234683 @default.
• W1960200240 cites W2101385080 @default.
• W1960200240 cites W2110667326 @default.
• W1960200240 cites W2125155374 @default.
• W1960200240 cites W2147791296 @default.
• W1960200240 cites W2151722542 @default.
• W1960200240 cites W2158184773 @default.
• W1960200240 cites W2165054307 @default.
• W1960200240 cites W2318876874 @default.
• W1960200240 doi "https://doi.org/10.1161/circulationaha.104.524801" @default.
• W1960200240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16159802" @default.
• W1960200240 hasPublicationYear "2005" @default.
• W1960200240 type Work @default.
• W1960200240 sameAs 1960200240 @default.
• W1960200240 citedByCount "47" @default.
• W1960200240 countsByYear W19602002402012 @default.
• W1960200240 countsByYear W19602002402013 @default.
• W1960200240 countsByYear W19602002402014 @default.
• W1960200240 countsByYear W19602002402015 @default.
• W1960200240 countsByYear W19602002402016 @default.
• W1960200240 countsByYear W19602002402017 @default.
• W1960200240 countsByYear W19602002402018 @default.
• W1960200240 countsByYear W19602002402019 @default.
• W1960200240 countsByYear W19602002402021 @default.
• W1960200240 countsByYear W19602002402022 @default.
• W1960200240 countsByYear W19602002402023 @default.
• W1960200240 crossrefType "journal-article" @default.
• W1960200240 hasAuthorship W1960200240A5000406175 @default.
• W1960200240 hasAuthorship W1960200240A5003364544 @default.
• W1960200240 hasAuthorship W1960200240A5016552031 @default.
• W1960200240 hasAuthorship W1960200240A5027420105 @default.
• W1960200240 hasAuthorship W1960200240A5042700458 @default.
• W1960200240 hasAuthorship W1960200240A5045094613 @default.
• W1960200240 hasAuthorship W1960200240A5056456336 @default.
• W1960200240 hasAuthorship W1960200240A5057857925 @default.
• W1960200240 hasAuthorship W1960200240A5059321865 @default.
• W1960200240 hasAuthorship W1960200240A5064539315 @default.
• W1960200240 hasAuthorship W1960200240A5065500721 @default.
• W1960200240 hasAuthorship W1960200240A5069532486 @default.
• W1960200240 hasAuthorship W1960200240A5073971504 @default.
• W1960200240 hasBestOaLocation W19602002401 @default.
• W1960200240 hasConcept C126322002 @default.
• W1960200240 hasConcept C164705383 @default.
• W1960200240 hasConcept C197321550 @default.
• W1960200240 hasConcept C201750760 @default.
• W1960200240 hasConcept C2776820930 @default.
• W1960200240 hasConcept C2777798775 @default.
• W1960200240 hasConcept C2780114680 @default.
• W1960200240 hasConcept C28328180 @default.
• W1960200240 hasConcept C42219234 @default.
• W1960200240 hasConcept C500558357 @default.
• W1960200240 hasConcept C541997718 @default.
• W1960200240 hasConcept C54355233 @default.
• W1960200240 hasConcept C71924100 @default.
• W1960200240 hasConcept C86803240 @default.
• W1960200240 hasConceptScore W1960200240C126322002 @default.
• W1960200240 hasConceptScore W1960200240C164705383 @default.
• W1960200240 hasConceptScore W1960200240C197321550 @default.
• W1960200240 hasConceptScore W1960200240C201750760 @default.
• W1960200240 hasConceptScore W1960200240C2776820930 @default.
• W1960200240 hasConceptScore W1960200240C2777798775 @default.
• W1960200240 hasConceptScore W1960200240C2780114680 @default.
• W1960200240 hasConceptScore W1960200240C28328180 @default.
• W1960200240 hasConceptScore W1960200240C42219234 @default.
• W1960200240 hasConceptScore W1960200240C500558357 @default.
• W1960200240 hasConceptScore W1960200240C541997718 @default.
• W1960200240 hasConceptScore W1960200240C54355233 @default.
• W1960200240 hasConceptScore W1960200240C71924100 @default.
• W1960200240 hasConceptScore W1960200240C86803240 @default.
• W1960200240 hasIssue "9_supplement" @default.

• next