FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1960474734> ?p ?o ?g. }

• W1960474734 endingPage "690" @default.
• W1960474734 startingPage "685" @default.
• W1960474734 abstract "ABSTRACTTo identify factors associated with Escherichia coli meningitis (ECM) mortality in infants aged <3 months, the clinical, biological and bacterial characteristics of isolates from 99 cases of ECM were compared, including the phylogenetic group, multilocus sequence type, O serogroup and sequence O type (a combination of sequence type complex (STc) and O serogroup) and virulence genotype. All 99 isolates were susceptible to the initial antimicrobial treatment. The mortality rate (14%) was not influenced by term or post-natal age. Hypotension or seizures were the sole clinical predictive factors for fatal outcome (p < 0.01), and abnormal initial trans-fontanellar ultrasound was associated with death (p 0.03). Seventy-seven isolates belonged to the common sequence O types (STc29O1STc29O18STc29O45STc301O7STc304O16STc697O83STc700O1) causing neonatal meningitis. None of the phylogenetic groups and none of the virulence determinants were distributed differently between survivors and non-survivors, except that the aerobactin gene (iucC) was less frequent in lethal isolates (94% vs. 71%, p 0.02). Isolates belonging to rare sequence O types were more likely to be lethal (OR 4.3, p 0.01), although they induced a lower level of bacteraemia than common sequence O types such as STc29O18 and STc29O45 in a neonatal rat model. These results suggest that unidentified human genetic risk-factors may be more important than strain virulence in predicting ECM mortality. ABSTRACT To identify factors associated with Escherichia coli meningitis (ECM) mortality in infants aged <3 months, the clinical, biological and bacterial characteristics of isolates from 99 cases of ECM were compared, including the phylogenetic group, multilocus sequence type, O serogroup and sequence O type (a combination of sequence type complex (STc) and O serogroup) and virulence genotype. All 99 isolates were susceptible to the initial antimicrobial treatment. The mortality rate (14%) was not influenced by term or post-natal age. Hypotension or seizures were the sole clinical predictive factors for fatal outcome (p < 0.01), and abnormal initial trans-fontanellar ultrasound was associated with death (p 0.03). Seventy-seven isolates belonged to the common sequence O types (STc29O1STc29O18STc29O45STc301O7STc304O16STc697O83STc700O1) causing neonatal meningitis. None of the phylogenetic groups and none of the virulence determinants were distributed differently between survivors and non-survivors, except that the aerobactin gene (iucC) was less frequent in lethal isolates (94% vs. 71%, p 0.02). Isolates belonging to rare sequence O types were more likely to be lethal (OR 4.3, p 0.01), although they induced a lower level of bacteraemia than common sequence O types such as STc29O18 and STc29O45 in a neonatal rat model. These results suggest that unidentified human genetic risk-factors may be more important than strain virulence in predicting ECM mortality." @default.
• W1960474734 created "2016-06-24" @default.
• W1960474734 creator A5021607681 @default.
• W1960474734 creator A5040498184 @default.
• W1960474734 creator A5051047014 @default.
• W1960474734 creator A5081161395 @default.
• W1960474734 creator A5082109593 @default.
• W1960474734 creator A5087589883 @default.
• W1960474734 creator A5089816470 @default.
• W1960474734 creator A5091444788 @default.
• W1960474734 date "2008-07-01" @default.
• W1960474734 modified "2023-10-17" @default.
• W1960474734 title "Association between mortality of Escherichia coli meningitis in young infants and non-virulent clonal groups of strains" @default.
• W1960474734 cites W1833453271 @default.
• W1960474734 cites W1973274802 @default.
• W1960474734 cites W1975298598 @default.
• W1960474734 cites W1975314423 @default.
• W1960474734 cites W1978457678 @default.
• W1960474734 cites W1979649993 @default.
• W1960474734 cites W2002548518 @default.
• W1960474734 cites W2013617289 @default.
• W1960474734 cites W2017923198 @default.
• W1960474734 cites W2036836556 @default.
• W1960474734 cites W2045594060 @default.
• W1960474734 cites W2050309345 @default.
• W1960474734 cites W2063805414 @default.
• W1960474734 cites W2074785664 @default.
• W1960474734 cites W2093956032 @default.
• W1960474734 cites W2094104004 @default.
• W1960474734 cites W2108992034 @default.
• W1960474734 cites W2132512062 @default.
• W1960474734 cites W2140212933 @default.
• W1960474734 cites W2162039208 @default.
• W1960474734 cites W2163377884 @default.
• W1960474734 cites W2166450130 @default.
• W1960474734 cites W2167799993 @default.
• W1960474734 cites W2167965269 @default.
• W1960474734 cites W7652690 @default.
• W1960474734 doi "https://doi.org/10.1111/j.1469-0691.2008.02019.x" @default.
• W1960474734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18558941" @default.
• W1960474734 hasPublicationYear "2008" @default.
• W1960474734 type Work @default.
• W1960474734 sameAs 1960474734 @default.
• W1960474734 citedByCount "30" @default.
• W1960474734 countsByYear W19604747342012 @default.
• W1960474734 countsByYear W19604747342013 @default.
• W1960474734 countsByYear W19604747342014 @default.
• W1960474734 countsByYear W19604747342015 @default.
• W1960474734 countsByYear W19604747342016 @default.
• W1960474734 countsByYear W19604747342017 @default.
• W1960474734 countsByYear W19604747342018 @default.
• W1960474734 countsByYear W19604747342019 @default.
• W1960474734 countsByYear W19604747342021 @default.
• W1960474734 countsByYear W19604747342023 @default.
• W1960474734 crossrefType "journal-article" @default.
• W1960474734 hasAuthorship W1960474734A5021607681 @default.
• W1960474734 hasAuthorship W1960474734A5040498184 @default.
• W1960474734 hasAuthorship W1960474734A5051047014 @default.
• W1960474734 hasAuthorship W1960474734A5081161395 @default.
• W1960474734 hasAuthorship W1960474734A5082109593 @default.
• W1960474734 hasAuthorship W1960474734A5087589883 @default.
• W1960474734 hasAuthorship W1960474734A5089816470 @default.
• W1960474734 hasAuthorship W1960474734A5091444788 @default.
• W1960474734 hasBestOaLocation W19604747341 @default.
• W1960474734 hasConcept C104317684 @default.
• W1960474734 hasConcept C135763542 @default.
• W1960474734 hasConcept C187212893 @default.
• W1960474734 hasConcept C193252679 @default.
• W1960474734 hasConcept C2778877157 @default.
• W1960474734 hasConcept C2781026528 @default.
• W1960474734 hasConcept C54355233 @default.
• W1960474734 hasConcept C547475151 @default.
• W1960474734 hasConcept C60987743 @default.
• W1960474734 hasConcept C71924100 @default.
• W1960474734 hasConcept C77434933 @default.
• W1960474734 hasConcept C86803240 @default.
• W1960474734 hasConcept C89423630 @default.
• W1960474734 hasConceptScore W1960474734C104317684 @default.
• W1960474734 hasConceptScore W1960474734C135763542 @default.
• W1960474734 hasConceptScore W1960474734C187212893 @default.
• W1960474734 hasConceptScore W1960474734C193252679 @default.
• W1960474734 hasConceptScore W1960474734C2778877157 @default.
• W1960474734 hasConceptScore W1960474734C2781026528 @default.
• W1960474734 hasConceptScore W1960474734C54355233 @default.
• W1960474734 hasConceptScore W1960474734C547475151 @default.
• W1960474734 hasConceptScore W1960474734C60987743 @default.
• W1960474734 hasConceptScore W1960474734C71924100 @default.
• W1960474734 hasConceptScore W1960474734C77434933 @default.
• W1960474734 hasConceptScore W1960474734C86803240 @default.
• W1960474734 hasConceptScore W1960474734C89423630 @default.
• W1960474734 hasIssue "7" @default.
• W1960474734 hasLocation W19604747341 @default.
• W1960474734 hasLocation W19604747342 @default.
• W1960474734 hasOpenAccess W1960474734 @default.
• W1960474734 hasPrimaryLocation W19604747341 @default.
• W1960474734 hasRelatedWork W1497553232 @default.
• W1960474734 hasRelatedWork W2108992034 @default.
• W1960474734 hasRelatedWork W2166450130 @default.

• next