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- W1960965614 endingPage "163" @default.
- W1960965614 startingPage "138" @default.
- W1960965614 abstract "The three classes of enzymes which inactivate aminoglycosides and lead to bacterial resistance are reviewed. DNA hybridization studies have shown that different genes can encode aminoglycoside-modifying enzymes with identical resistance profiles. Comparisons of the amino acid sequences of 49 aminoglycoside-modifying enzymes have revealed new insights into the evolution and relatedness of these proteins. A preliminary assessment of the amino acids which may be important in binding aminoglycosides was obtained from these data and from the results of mutational analysis of several of the genes encoding aminoglycoside-modifying enzymes. Recent studies have demonstrated that aminoglycoside resistance can emerge as a result of alterations in the regulation of normally quiescent cellular genes or as a result of acquiring genes which may have originated from aminoglycoside-producing organisms or from other resistant organisms. Dissemination of these genes is aided by a variety of genetic elements including integrons, transposons, and broad-host-range plasmids. As knowledge of the molecular structure of these enzymes increases, progress can be made in our understanding of how resistance to new aminoglycosides emerges." @default.
- W1960965614 created "2016-06-24" @default.
- W1960965614 creator A5023507590 @default.
- W1960965614 creator A5026715391 @default.
- W1960965614 creator A5081065256 @default.
- W1960965614 creator A5086601088 @default.
- W1960965614 date "1993-03-01" @default.
- W1960965614 modified "2023-10-16" @default.
- W1960965614 title "Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes" @default.
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