FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1961036010> ?p ?o ?g. }

• W1961036010 endingPage "1488" @default.
• W1961036010 startingPage "1481" @default.
• W1961036010 abstract "Metastases are the primary cause of human cancer deaths. Luteolin, a naturally occurring phytochemical, has chemopreventive and/or anticancer properties in several cancer cell lines. However, anti-metastatic effects of luteolin in vivo and the underlying molecular mechanisms and target(s) remain unknown. Luteolin suppresses matrix metalloproteinase (MMP)-2 and -9 activities and invasion in murine colorectal cancer CT-26 cells. Western blot and kinase assay data revealed that luteolin inhibited Raf and phosphatidylinositol 3-kinase (PI3K) activities and subsequently attenuated phosphorylation of MEK and Akt. A pull-down assay indicated that luteolin non-competitively bound with ATP to suppress Raf activity and competitively bound with ATP to inhibit PI3K activity. GW5074, a Raf inhibitor, and LY294002, a PI3K inhibitor, inhibited MMP-2 and -9 activities and invasion in CT-26 cells. An in vivo mouse study showed that oral administration (10 or 50 mg/kg) of luteolin significantly inhibited tumor nodules and tumor volume of lung metastasis induced by intravenous injection of CT-26 cells. Luteolin also inhibited MMP-9 expression and activity in CT-26-induced mouse lung tissue. These results suggest that luteolin may have considerable potential for development as an anti-metastatic agent. Copyright © 2012 John Wiley & Sons, Ltd." @default.
• W1961036010 created "2016-06-24" @default.
• W1961036010 creator A5000045048 @default.
• W1961036010 creator A5002301742 @default.
• W1961036010 creator A5006050449 @default.
• W1961036010 creator A5007606574 @default.
• W1961036010 creator A5022976734 @default.
• W1961036010 creator A5032700159 @default.
• W1961036010 creator A5045877476 @default.
• W1961036010 creator A5050867707 @default.
• W1961036010 creator A5061290019 @default.
• W1961036010 creator A5075153617 @default.
• W1961036010 date "2012-11-21" @default.
• W1961036010 modified "2023-10-04" @default.
• W1961036010 title "Raf and PI3K are the Molecular Targets for the Anti-metastatic Effect of Luteolin" @default.
• W1961036010 cites W1600545176 @default.
• W1961036010 cites W1914304108 @default.
• W1961036010 cites W1940470282 @default.
• W1961036010 cites W1984483611 @default.
• W1961036010 cites W2003500892 @default.
• W1961036010 cites W2015032157 @default.
• W1961036010 cites W2025750169 @default.
• W1961036010 cites W2036460370 @default.
• W1961036010 cites W2052626837 @default.
• W1961036010 cites W2058480405 @default.
• W1961036010 cites W2070455847 @default.
• W1961036010 cites W2072619337 @default.
• W1961036010 cites W2084867085 @default.
• W1961036010 cites W2087861588 @default.
• W1961036010 cites W2091578340 @default.
• W1961036010 cites W2093953040 @default.
• W1961036010 cites W2095947302 @default.
• W1961036010 cites W2107614388 @default.
• W1961036010 cites W2108838456 @default.
• W1961036010 cites W2108889231 @default.
• W1961036010 cites W2109069677 @default.
• W1961036010 cites W2109099165 @default.
• W1961036010 cites W2110438717 @default.
• W1961036010 cites W2119912258 @default.
• W1961036010 cites W2123541095 @default.
• W1961036010 cites W2124224001 @default.
• W1961036010 cites W2124662474 @default.
• W1961036010 cites W2130463902 @default.
• W1961036010 cites W2132527654 @default.
• W1961036010 cites W2154944654 @default.
• W1961036010 doi "https://doi.org/10.1002/ptr.4888" @default.
• W1961036010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23172826" @default.
• W1961036010 hasPublicationYear "2012" @default.
• W1961036010 type Work @default.
• W1961036010 sameAs 1961036010 @default.
• W1961036010 citedByCount "33" @default.
• W1961036010 countsByYear W19610360102013 @default.
• W1961036010 countsByYear W19610360102014 @default.
• W1961036010 countsByYear W19610360102015 @default.
• W1961036010 countsByYear W19610360102016 @default.
• W1961036010 countsByYear W19610360102017 @default.
• W1961036010 countsByYear W19610360102018 @default.
• W1961036010 countsByYear W19610360102019 @default.
• W1961036010 countsByYear W19610360102020 @default.
• W1961036010 countsByYear W19610360102021 @default.
• W1961036010 countsByYear W19610360102022 @default.
• W1961036010 countsByYear W19610360102023 @default.
• W1961036010 crossrefType "journal-article" @default.
• W1961036010 hasAuthorship W1961036010A5000045048 @default.
• W1961036010 hasAuthorship W1961036010A5002301742 @default.
• W1961036010 hasAuthorship W1961036010A5006050449 @default.
• W1961036010 hasAuthorship W1961036010A5007606574 @default.
• W1961036010 hasAuthorship W1961036010A5022976734 @default.
• W1961036010 hasAuthorship W1961036010A5032700159 @default.
• W1961036010 hasAuthorship W1961036010A5045877476 @default.
• W1961036010 hasAuthorship W1961036010A5050867707 @default.
• W1961036010 hasAuthorship W1961036010A5061290019 @default.
• W1961036010 hasAuthorship W1961036010A5075153617 @default.
• W1961036010 hasConcept C104317684 @default.
• W1961036010 hasConcept C11960822 @default.
• W1961036010 hasConcept C121608353 @default.
• W1961036010 hasConcept C126322002 @default.
• W1961036010 hasConcept C150903083 @default.
• W1961036010 hasConcept C184235292 @default.
• W1961036010 hasConcept C185592680 @default.
• W1961036010 hasConcept C207001950 @default.
• W1961036010 hasConcept C2776080593 @default.
• W1961036010 hasConcept C2776415932 @default.
• W1961036010 hasConcept C2776912716 @default.
• W1961036010 hasConcept C2778004101 @default.
• W1961036010 hasConcept C2779013556 @default.
• W1961036010 hasConcept C2779054382 @default.
• W1961036010 hasConcept C502942594 @default.
• W1961036010 hasConcept C55493867 @default.
• W1961036010 hasConcept C57074206 @default.
• W1961036010 hasConcept C62478195 @default.
• W1961036010 hasConcept C71924100 @default.
• W1961036010 hasConcept C75217442 @default.
• W1961036010 hasConcept C86554907 @default.
• W1961036010 hasConcept C86803240 @default.
• W1961036010 hasConcept C98274493 @default.
• W1961036010 hasConceptScore W1961036010C104317684 @default.
• W1961036010 hasConceptScore W1961036010C11960822 @default.

• next