FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1961042950> ?p ?o ?g. }

• W1961042950 endingPage "285" @default.
• W1961042950 startingPage "280" @default.
• W1961042950 abstract "Kv7 voltage-gated potassium channels have been suggested to modulate mechano-afferent transduction and nociception in the bladder. We investigated the effects of retigabine, a Kv7 channel activator, on rhythmic bladder contractions (RBCs), and single-unit afferent activities (SAAs) of the primary bladder mechanosensitive afferent nerve fibers in urethane-anesthetized rats. In addition, the effects of pretreatment with retigabine on the nociceptive behaviors provoked by an intravesical instillation of resiniferatoxin (RTX) were evaluated in the conscious condition.Female Sprague-Dawley rats were used. Under urethane anesthesia, saline was instilled into the bladder until RBCs were induced reproducibly. Then, the effects of intravenous, cumulative administrations of retigabine (0.1-3 mg/kg) or vehicle (saline) on RBCs were assessed. In separate animals, SAAs of Aδ- and C-fibers were identified by electrical stimulation of the pelvic nerve and by bladder distention with saline. After baseline recording, vehicle or retigabine (0.01-1 mg/kg) was administered intravenously and further recordings were performed. Under pretreatment with vehicle or retigabine (3 mg/kg intraperitoneally), the frequencies of lower abdominal licking and freezing were counted and scored as the bladder nociceptive behaviors induced by intravesical RTX instillation (3 µM, 0.3 ml).Retigabine dose-dependently decreased both the frequency and the amplitude of RBCs and SAAs of both Aδ- and C-fibers. The effect on RBCs was more potent on the frequency than the amplitude. Retigabine inhibited the RTX-induced abdominal licking, but not freezing.Kv7 channels are likely to be implicated in inhibition of bladder mechano- and nociceptive sensory transduction. Neurourol. Urodynam. 36:280-285, 2017. © 2015 Wiley Periodicals, Inc." @default.
• W1961042950 created "2016-06-24" @default.
• W1961042950 creator A5023676293 @default.
• W1961042950 creator A5025968480 @default.
• W1961042950 creator A5035963252 @default.
• W1961042950 creator A5050328322 @default.
• W1961042950 creator A5057338410 @default.
• W1961042950 creator A5062412353 @default.
• W1961042950 creator A5063388966 @default.
• W1961042950 creator A5071062016 @default.
• W1961042950 date "2015-11-04" @default.
• W1961042950 modified "2023-10-14" @default.
• W1961042950 title "Inhibitory effects of retigabine, a Kv7 channel activator, on mechanosensitive primary bladder afferent activities and nociceptive behaviors in rats" @default.
• W1961042950 cites W1501148390 @default.
• W1961042950 cites W1736719008 @default.
• W1961042950 cites W1799090833 @default.
• W1961042950 cites W1975705594 @default.
• W1961042950 cites W1987604209 @default.
• W1961042950 cites W2008977920 @default.
• W1961042950 cites W2011074447 @default.
• W1961042950 cites W2030945247 @default.
• W1961042950 cites W2031542810 @default.
• W1961042950 cites W2057487165 @default.
• W1961042950 cites W2118970449 @default.
• W1961042950 cites W2123436987 @default.
• W1961042950 cites W2142057644 @default.
• W1961042950 cites W2148884191 @default.
• W1961042950 cites W2157428360 @default.
• W1961042950 cites W2169016904 @default.
• W1961042950 cites W2283622476 @default.
• W1961042950 doi "https://doi.org/10.1002/nau.22920" @default.
• W1961042950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26536146" @default.
• W1961042950 hasPublicationYear "2015" @default.
• W1961042950 type Work @default.
• W1961042950 sameAs 1961042950 @default.
• W1961042950 citedByCount "12" @default.
• W1961042950 countsByYear W19610429502016 @default.
• W1961042950 countsByYear W19610429502017 @default.
• W1961042950 countsByYear W19610429502018 @default.
• W1961042950 countsByYear W19610429502019 @default.
• W1961042950 countsByYear W19610429502020 @default.
• W1961042950 countsByYear W19610429502021 @default.
• W1961042950 countsByYear W19610429502022 @default.
• W1961042950 countsByYear W19610429502023 @default.
• W1961042950 crossrefType "journal-article" @default.
• W1961042950 hasAuthorship W1961042950A5023676293 @default.
• W1961042950 hasAuthorship W1961042950A5025968480 @default.
• W1961042950 hasAuthorship W1961042950A5035963252 @default.
• W1961042950 hasAuthorship W1961042950A5050328322 @default.
• W1961042950 hasAuthorship W1961042950A5057338410 @default.
• W1961042950 hasAuthorship W1961042950A5062412353 @default.
• W1961042950 hasAuthorship W1961042950A5063388966 @default.
• W1961042950 hasAuthorship W1961042950A5071062016 @default.
• W1961042950 hasConcept C126322002 @default.
• W1961042950 hasConcept C15490471 @default.
• W1961042950 hasConcept C155164980 @default.
• W1961042950 hasConcept C160145004 @default.
• W1961042950 hasConcept C170493617 @default.
• W1961042950 hasConcept C24998067 @default.
• W1961042950 hasConcept C2776354303 @default.
• W1961042950 hasConcept C2777397205 @default.
• W1961042950 hasConcept C2780723003 @default.
• W1961042950 hasConcept C4001165 @default.
• W1961042950 hasConcept C42219234 @default.
• W1961042950 hasConcept C50254741 @default.
• W1961042950 hasConcept C71924100 @default.
• W1961042950 hasConcept C98274493 @default.
• W1961042950 hasConceptScore W1961042950C126322002 @default.
• W1961042950 hasConceptScore W1961042950C15490471 @default.
• W1961042950 hasConceptScore W1961042950C155164980 @default.
• W1961042950 hasConceptScore W1961042950C160145004 @default.
• W1961042950 hasConceptScore W1961042950C170493617 @default.
• W1961042950 hasConceptScore W1961042950C24998067 @default.
• W1961042950 hasConceptScore W1961042950C2776354303 @default.
• W1961042950 hasConceptScore W1961042950C2777397205 @default.
• W1961042950 hasConceptScore W1961042950C2780723003 @default.
• W1961042950 hasConceptScore W1961042950C4001165 @default.
• W1961042950 hasConceptScore W1961042950C42219234 @default.
• W1961042950 hasConceptScore W1961042950C50254741 @default.
• W1961042950 hasConceptScore W1961042950C71924100 @default.
• W1961042950 hasConceptScore W1961042950C98274493 @default.
• W1961042950 hasIssue "2" @default.
• W1961042950 hasLocation W19610429501 @default.
• W1961042950 hasLocation W19610429502 @default.
• W1961042950 hasOpenAccess W1961042950 @default.
• W1961042950 hasPrimaryLocation W19610429501 @default.
• W1961042950 hasRelatedWork W140368183 @default.
• W1961042950 hasRelatedWork W1961042950 @default.
• W1961042950 hasRelatedWork W1972722231 @default.
• W1961042950 hasRelatedWork W1973239820 @default.
• W1961042950 hasRelatedWork W2020288760 @default.
• W1961042950 hasRelatedWork W2028124009 @default.
• W1961042950 hasRelatedWork W2057487165 @default.
• W1961042950 hasRelatedWork W2069239274 @default.
• W1961042950 hasRelatedWork W2085014438 @default.
• W1961042950 hasRelatedWork W2085468483 @default.
• W1961042950 hasVolume "36" @default.
• W1961042950 isParatext "false" @default.

• next