FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1961049630> ?p ?o ?g. }

• W1961049630 endingPage "182" @default.
• W1961049630 startingPage "172" @default.
• W1961049630 abstract "The PKC1 gene of Saccharomyces cerevisiae encodes a homolog of mammalian protein kinase C that is required for yeast cell growth and division. To identify additional components of the pathway in which PKC1 functions, we isolated extragenic suppressors of a pkc1 deletion mutant. All of the suppressor mutations were dominant for suppressor function and defined a single locus, which was designated BCK1 (for bypass of C kinase). A molecular clone of one suppressor allele, BCK1-20, was isolated on a centromere-containing plasmid through its ability to rescue a conditional pkc1 mutant. The BCK1 gene possesses a 4.4-kb uninterrupted open reading frame predicted to encode a 163-kDa protein kinase. The BCK1 gene product is not closely related to any known protein kinase, sharing only 45% amino acid identity with its closest known relative (the STE11-encoded protein kinase) through a region restricted to its putative C-terminal catalytic domain. Deletion of BCK1 resulted in a temperature-sensitive cell lysis defect, which was suppressed by osmotic stabilizing agents. Because pkc1 mutants also display a cell lysis defect, we suggest that PKC1 and BCK1 may normally function within the same pathway. Suppressor alleles of BCK1 differed from the wild-type gene in a region surrounding a potential PKC phosphorylation site immediately upstream of the predicted catalytic domain. This region may serve as a hinge between domains whose interaction is regulated by PKC1." @default.
• W1961049630 created "2016-06-24" @default.
• W1961049630 creator A5030324306 @default.
• W1961049630 creator A5056383381 @default.
• W1961049630 date "1992-01-01" @default.
• W1961049630 modified "2023-09-30" @default.
• W1961049630 title "Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog" @default.
• W1961049630 cites W109451225 @default.
• W1961049630 cites W1489317543 @default.
• W1961049630 cites W1534834744 @default.
• W1961049630 cites W1537782690 @default.
• W1961049630 cites W1557498748 @default.
• W1961049630 cites W1964839077 @default.
• W1961049630 cites W1965168699 @default.
• W1961049630 cites W1967004332 @default.
• W1961049630 cites W1967925725 @default.
• W1961049630 cites W1969737313 @default.
• W1961049630 cites W1971925799 @default.
• W1961049630 cites W1973782344 @default.
• W1961049630 cites W1976245365 @default.
• W1961049630 cites W1988936390 @default.
• W1961049630 cites W1991445188 @default.
• W1961049630 cites W1993282564 @default.
• W1961049630 cites W1995499596 @default.
• W1961049630 cites W2003676968 @default.
• W1961049630 cites W2015292449 @default.
• W1961049630 cites W2017867661 @default.
• W1961049630 cites W2018149328 @default.
• W1961049630 cites W2020257412 @default.
• W1961049630 cites W2021253208 @default.
• W1961049630 cites W2027782335 @default.
• W1961049630 cites W2034380361 @default.
• W1961049630 cites W2040380855 @default.
• W1961049630 cites W2044952215 @default.
• W1961049630 cites W2047202913 @default.
• W1961049630 cites W2048500913 @default.
• W1961049630 cites W2050499271 @default.
• W1961049630 cites W2055871144 @default.
• W1961049630 cites W2063450941 @default.
• W1961049630 cites W2068877244 @default.
• W1961049630 cites W2080119769 @default.
• W1961049630 cites W2080229333 @default.
• W1961049630 cites W2083025927 @default.
• W1961049630 cites W2083869788 @default.
• W1961049630 cites W2088072731 @default.
• W1961049630 cites W2091673674 @default.
• W1961049630 cites W2092812701 @default.
• W1961049630 cites W2093458878 @default.
• W1961049630 cites W2096077209 @default.
• W1961049630 cites W2106928904 @default.
• W1961049630 cites W2111691978 @default.
• W1961049630 cites W2112365969 @default.
• W1961049630 cites W2124923437 @default.
• W1961049630 cites W2132417094 @default.
• W1961049630 cites W2133184855 @default.
• W1961049630 cites W2138270253 @default.
• W1961049630 cites W2142339245 @default.
• W1961049630 cites W2164515753 @default.
• W1961049630 cites W2169333620 @default.
• W1961049630 cites W2226935353 @default.
• W1961049630 cites W2229607380 @default.
• W1961049630 doi "https://doi.org/10.1128/mcb.12.1.172-182.1992" @default.
• W1961049630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/364081" @default.
• W1961049630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1729597" @default.
• W1961049630 hasPublicationYear "1992" @default.
• W1961049630 type Work @default.
• W1961049630 sameAs 1961049630 @default.
• W1961049630 citedByCount "169" @default.
• W1961049630 countsByYear W19610496302012 @default.
• W1961049630 countsByYear W19610496302013 @default.
• W1961049630 countsByYear W19610496302014 @default.
• W1961049630 countsByYear W19610496302015 @default.
• W1961049630 countsByYear W19610496302016 @default.
• W1961049630 countsByYear W19610496302017 @default.
• W1961049630 countsByYear W19610496302018 @default.
• W1961049630 countsByYear W19610496302019 @default.
• W1961049630 countsByYear W19610496302021 @default.
• W1961049630 countsByYear W19610496302022 @default.
• W1961049630 countsByYear W19610496302023 @default.
• W1961049630 crossrefType "journal-article" @default.
• W1961049630 hasAuthorship W1961049630A5030324306 @default.
• W1961049630 hasAuthorship W1961049630A5056383381 @default.
• W1961049630 hasConcept C104317684 @default.
• W1961049630 hasConcept C143065580 @default.
• W1961049630 hasConcept C150194340 @default.
• W1961049630 hasConcept C153911025 @default.
• W1961049630 hasConcept C184235292 @default.
• W1961049630 hasConcept C195286587 @default.
• W1961049630 hasConcept C195794163 @default.
• W1961049630 hasConcept C2777576037 @default.
• W1961049630 hasConcept C54355233 @default.
• W1961049630 hasConcept C84597430 @default.
• W1961049630 hasConcept C86803240 @default.
• W1961049630 hasConcept C97029542 @default.
• W1961049630 hasConceptScore W1961049630C104317684 @default.
• W1961049630 hasConceptScore W1961049630C143065580 @default.
• W1961049630 hasConceptScore W1961049630C150194340 @default.
• W1961049630 hasConceptScore W1961049630C153911025 @default.

• next