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- W1961065159 abstract "Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide that in mammalian testis is involved in the control of testosterone and 17β-estradiol synthesis. A similar involvement was recently postulated in the testis of a nonmammalian vertebrate, the wall lizard Podarcis sicula. Indeed, we reported the presence of PACAP and its receptors throughout the reproductive cycle within both germ and somatic cells. Now, we investigated the effects of PACAP on steroidogenesis in significant periods of Podarcis reproductive cycle: winter stasis, reproductive period and summer stasis. Using different in vitro treatments, in the absence or presence of receptor antagonists, we demonstrated that in P. sicula testis PACAP is involved in the control of testosterone and 17β-estradiol production. In particular we demonstrated that treatment with PACAP induced a testosterone increase only in stasis periods (winter and summer stasis); differently they induced a 17β-estradiol production in all periods analyzed (summer stasis, winter stasis and reproductive period)." @default.
- W1961065159 created "2016-06-24" @default.
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- W1961065159 date "2016-01-01" @default.
- W1961065159 modified "2023-09-27" @default.
- W1961065159 title "Role of PACAP on testosterone and 17β-estradiol production in the testis of wall lizard Podarcis sicula" @default.
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- W1961065159 doi "https://doi.org/10.1016/j.cbpa.2015.10.022" @default.
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