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- W1961244152 abstract "The present study evaluated the protective effect of Centella asiatica (gotu kola) leaf extract (CAE) against indomethacin (IND)-induced gastric mucosal injury in rats. Gastric mucosal injury was induced by the oral administration of IND to the rats after a 24 h fast. CAE (50 or 250 mg/kg) or lansoprazole (a reference drug) was orally administrated 30 min before the IND administration, and 5 h later, the stomachs were removed to quantify the lesions. Orally administered CAE significantly reduced IND-induced gastric injury. The histopathological observations (hematoxylin-eosin and Periodic acid-Schiff staining) confirmed the protection against gastric mucosal injury. Also, CAE decreased the malondialdehyde content compared to the control group. Moreover, pretreatment with CAE resulted in a significant reduction in the elevated expression of tumor necrosis factor, Cyclooxygenase (COX)-2, and inducible nitric oxide synthase. These results suggested that CAE possesses gastroprotective effects against IND-induced gastric mucosal injury, which could be attributed to its ability to inhibit lipid peroxidation and stimulate gastric mucus secretion in the rat gastric mucosa." @default.
- W1961244152 created "2016-06-24" @default.
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- W1961244152 date "2016-01-01" @default.
- W1961244152 modified "2023-10-18" @default.
- W1961244152 title "<i>Centella asiatica</i>Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats" @default.
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- W1961244152 doi "https://doi.org/10.1089/jmf.2015.3464" @default.
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