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• W1961251946 abstract "// Christoph Burdelski 1, * , Christian Strauss 2, * , Maria Christina Tsourlakis 2 , Martina Kluth 2 , Claudia Hube-Magg 2 , Nathaniel Melling 1 , Patrick Lebok 2 , Sarah Minner 2 , Christina Koop 2 , Markus Graefen 3 , Hans Heinzer 3 , Corinna Wittmer 2 , Till Krech 2 , Guido Sauter 2 , Waldemar Wilczak 2 , Ronald Simon 2 , Thorsten Schlomm 3, 4 , Stefan Steurer 2 1 General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Germany 2 Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany 3 Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Germany 4 Department of Urology, Section for translational Prostate Cancer Research, University Medical Center Hamburg-Eppendorf, Germany * These authors have contributed equally to this work Correspondence to: Ronald Simon, e-mail: r.simon@uke.de Keywords: TYMS, prostate cancer, TMPRSS2-ERG fusion, tissue microarray, prognosis Received: December 18, 2014      Accepted: January 08, 2015      Published: February 25, 2015 ABSTRACT Thymidylate synthase (TYMS) plays a role in DNA synthesis and is a target for 5-fluorouracil. In this study TYMS was analyzed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers. TYMS expression was higher in neoplastic than in normal prostate epithelium and was detectable in 72.9% of 10,223 interpretable cancers. It was considered strong in 21.9%, moderate in 33.4% and weak in 17.6% of tumors. TYMS overexpression was associated with deletions at 5q21 ( p < 0.0001), 6q15 ( p < 0.0001) and 3p13 ( p = 0.0083) and gradually increased with the total number of these deletions present in the respective cancer sample ( p < 0.0001). TYMS expression was unrelated to PTEN deletions ( p = 0.9535) but tightly linked to high Gleason grade, advanced pathological tumor stage and early PSA recurrence ( p < 0.0001). The prognostic value of TYMS was independent from the ERG status and deletions at 3p13, 5q21, and 6q15. In multivariate analyses the prognostic role of TYMS expression was independent of Gleason grade, pT stage, preoperative PSA, pN stage, or resection margins. TYMS expression analysis might result in clinically useful information in prostate cancer. The striking link to some but not all chromosomal aberrations might suggest a mechanistical link with specific types of DNA damage." @default.
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• W1961251946 date "2015-02-25" @default.
• W1961251946 modified "2023-10-01" @default.
• W1961251946 title "Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer" @default.
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• W1961251946 doi "https://doi.org/10.18632/oncotarget.3107" @default.
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