FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1961338138> ?p ?o ?g. }

• W1961338138 endingPage "2525" @default.
• W1961338138 startingPage "2515" @default.
• W1961338138 abstract "There exists a substantial body of work describing cardiac support devices to mechanically support the left ventricle (LV); however, these devices lack biological effects. To remedy this, we implemented a cell sheet engineering approach utilizing chondrocytes, which in their natural environment produce a relatively elastic extracellular matrix (ECM) for a cushioning effect. Therefore, we hypothesized that a chondrocyte cell sheet applied to infarcted and borderzone myocardium will biologically enhance the ventricular ECM and increase elasticity to augment cardiac function in a model of ischemic cardiomyopathy (ICM). Primary articular cartilage chondrocytes of Wistar rats were isolated and cultured on temperature-responsive culture dishes to generate cell sheets. A rodent ICM model was created by ligating the left anterior descending coronary artery. Rats were divided into two groups: cell sheet transplantation (1.0 × 10(7) cells/dish) and no treatment. The cell sheet was placed onto the surface of the heart covering the infarct and borderzone areas. At 4 weeks following treatment, the decreased fibrotic extension and increased elastic microfiber networks in the infarct and borderzone areas correlated with this technology's potential to stimulate ECM formation. The enhanced ventricular elasticity was further confirmed by the axial stretch test, which revealed that the cell sheet tended to attenuate tensile modulus, a parameter of stiffness. This translated to increased wall thickness in the infarct area, decreased LV volume, wall stress, mass, and improvement of LV function. Thus, the chondrocyte cell sheet strengthens the ventricular biomechanical properties by inducing the formation of elastic microfiber networks in ICM, resulting in attenuated myocardial stiffness and improved myocardial function." @default.
• W1961338138 created "2016-06-24" @default.
• W1961338138 creator A5002360197 @default.
• W1961338138 creator A5004761665 @default.
• W1961338138 creator A5006585859 @default.
• W1961338138 creator A5006638778 @default.
• W1961338138 creator A5008435309 @default.
• W1961338138 creator A5020792039 @default.
• W1961338138 creator A5026202903 @default.
• W1961338138 creator A5032368496 @default.
• W1961338138 creator A5035282474 @default.
• W1961338138 creator A5043395309 @default.
• W1961338138 creator A5045168236 @default.
• W1961338138 creator A5045683397 @default.
• W1961338138 creator A5055550400 @default.
• W1961338138 creator A5056965717 @default.
• W1961338138 creator A5057824212 @default.
• W1961338138 creator A5063472572 @default.
• W1961338138 creator A5085075053 @default.
• W1961338138 date "2015-10-01" @default.
• W1961338138 modified "2023-09-25" @default.
• W1961338138 title "A Tissue-Engineered Chondrocyte Cell Sheet Induces Extracellular Matrix Modification to Enhance Ventricular Biomechanics and Attenuate Myocardial Stiffness in Ischemic Cardiomyopathy" @default.
• W1961338138 cites W1947713323 @default.
• W1961338138 cites W1963773881 @default.
• W1961338138 cites W1968760803 @default.
• W1961338138 cites W1974735076 @default.
• W1961338138 cites W1979900124 @default.
• W1961338138 cites W1980780439 @default.
• W1961338138 cites W1990224341 @default.
• W1961338138 cites W1990325505 @default.
• W1961338138 cites W1994717334 @default.
• W1961338138 cites W2001236781 @default.
• W1961338138 cites W2008925446 @default.
• W1961338138 cites W2019249741 @default.
• W1961338138 cites W2030238721 @default.
• W1961338138 cites W2051151043 @default.
• W1961338138 cites W2051991058 @default.
• W1961338138 cites W2058168927 @default.
• W1961338138 cites W2062185758 @default.
• W1961338138 cites W2065812287 @default.
• W1961338138 cites W2079769019 @default.
• W1961338138 cites W2084311974 @default.
• W1961338138 cites W2096534563 @default.
• W1961338138 cites W2110365781 @default.
• W1961338138 cites W2122168706 @default.
• W1961338138 cites W2124894661 @default.
• W1961338138 cites W2133020816 @default.
• W1961338138 cites W2142226970 @default.
• W1961338138 cites W2147005862 @default.
• W1961338138 cites W2153760303 @default.
• W1961338138 cites W2162368366 @default.
• W1961338138 cites W2327360949 @default.
• W1961338138 cites W2331925856 @default.
• W1961338138 doi "https://doi.org/10.1089/ten.tea.2014.0155" @default.
• W1961338138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4605354" @default.
• W1961338138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26154752" @default.
• W1961338138 hasPublicationYear "2015" @default.
• W1961338138 type Work @default.
• W1961338138 sameAs 1961338138 @default.
• W1961338138 citedByCount "11" @default.
• W1961338138 countsByYear W19613381382016 @default.
• W1961338138 countsByYear W19613381382017 @default.
• W1961338138 countsByYear W19613381382020 @default.
• W1961338138 countsByYear W19613381382021 @default.
• W1961338138 countsByYear W19613381382022 @default.
• W1961338138 crossrefType "journal-article" @default.
• W1961338138 hasAuthorship W1961338138A5002360197 @default.
• W1961338138 hasAuthorship W1961338138A5004761665 @default.
• W1961338138 hasAuthorship W1961338138A5006585859 @default.
• W1961338138 hasAuthorship W1961338138A5006638778 @default.
• W1961338138 hasAuthorship W1961338138A5008435309 @default.
• W1961338138 hasAuthorship W1961338138A5020792039 @default.
• W1961338138 hasAuthorship W1961338138A5026202903 @default.
• W1961338138 hasAuthorship W1961338138A5032368496 @default.
• W1961338138 hasAuthorship W1961338138A5035282474 @default.
• W1961338138 hasAuthorship W1961338138A5043395309 @default.
• W1961338138 hasAuthorship W1961338138A5045168236 @default.
• W1961338138 hasAuthorship W1961338138A5045683397 @default.
• W1961338138 hasAuthorship W1961338138A5055550400 @default.
• W1961338138 hasAuthorship W1961338138A5056965717 @default.
• W1961338138 hasAuthorship W1961338138A5057824212 @default.
• W1961338138 hasAuthorship W1961338138A5063472572 @default.
• W1961338138 hasAuthorship W1961338138A5085075053 @default.
• W1961338138 hasBestOaLocation W19613381382 @default.
• W1961338138 hasConcept C105702510 @default.
• W1961338138 hasConcept C12554922 @default.
• W1961338138 hasConcept C126322002 @default.
• W1961338138 hasConcept C136229726 @default.
• W1961338138 hasConcept C164705383 @default.
• W1961338138 hasConcept C170700871 @default.
• W1961338138 hasConcept C185592680 @default.
• W1961338138 hasConcept C189165786 @default.
• W1961338138 hasConcept C192562407 @default.
• W1961338138 hasConcept C2778921608 @default.
• W1961338138 hasConcept C2911091166 @default.
• W1961338138 hasConcept C49892992 @default.
• W1961338138 hasConcept C55493867 @default.
• W1961338138 hasConcept C71924100 @default.

• next