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- W1961431364 endingPage "21" @default.
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- W1961431364 abstract "Telomerase can compensate for telomere shortening and helps prevent cellular senescence in eukaryotic cells. In humans, only specific germline cells and the vast majority of cancer cells have sufficient activity for indefinite proliferation. Lymphocytes and stem/progenitor cells in self-renewal tissues have weak activity for extension of their lifespan, but they still undergo replicative senescence. In contrast, most somatic cells do not have telomerase activity and display a finite replicative lifespan. Heterozygous mutations in either of principal telomerase components, TERT or TERC, cause telomere dysfunction and unexpectedly early senescence to stem cells of renewal tissues. Thus, restoration of telomere function in regenerative medicine via telomerase expression and inhibition of telomerase as an anticancer strategy is a double-edged sword of telomeres and telomerase in clinical medicine." @default.
- W1961431364 created "2016-06-24" @default.
- W1961431364 creator A5025205330 @default.
- W1961431364 creator A5027813941 @default.
- W1961431364 creator A5081012778 @default.
- W1961431364 date "2009-01-01" @default.
- W1961431364 modified "2023-09-22" @default.
- W1961431364 title "Telomeres and Telomerase in Humans" @default.
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