FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1961434898> ?p ?o ?g. }

• W1961434898 endingPage "1827" @default.
• W1961434898 startingPage "1817" @default.
• W1961434898 abstract "The hallmark of primary biliary cirrhosis (PBC) is the presence of autoreactive T- and B-cell responses that target biliary epithelial cells (BECs). Biliary cell cytotoxicity is dependent upon initiation of innate immune responses followed by chronic adaptive, as well as bystander, mechanisms. Critical to these mechanisms are interactions between natural killer (NK) cells and BECs. We have taken advantage of the ability to isolate relatively pure viable preparations of liver-derived NK cells, BECs, and endothelial cells, and studied interactions between NK cells and BECs and focused on the mechanisms that activate autoreactive T cells, their dependence on interferon (IFN)-γ, and expression of BEC major histocompatibility complex (MHC) class I and II molecules. Here we show that at a high NK/BEC ratio, NK cells are cytotoxic for autologous BECs, but are not dependent on autoantigen, yet still activate autoreactive CD4(+) T cells in the presence of antigen presenting cells. In contrast, at a low NK/BEC ratio, BECs are not lysed, but IFN-γ production is induced, which facilitates expression of MHC class I and II molecules on BEC and protects them from lysis upon subsequent exposure to autoreactive NK cells. Furthermore, IFN-γ secreted from NK cells after exposure to autologous BECs is essential for this protective function and enables autoreactive CD4(+) T cells to become cytopathic.NK cell-mediated innate immune responses are likely critical at the initial stage of PBC, but also facilitate and maintain the chronic cytopathic effect of autoantigen-specific T cells, essential for progression of disease." @default.
• W1961434898 created "2016-06-24" @default.
• W1961434898 creator A5004420462 @default.
• W1961434898 creator A5008696378 @default.
• W1961434898 creator A5008794738 @default.
• W1961434898 creator A5012550681 @default.
• W1961434898 creator A5012890035 @default.
• W1961434898 creator A5016018624 @default.
• W1961434898 creator A5026278665 @default.
• W1961434898 creator A5029678899 @default.
• W1961434898 creator A5030939408 @default.
• W1961434898 creator A5037162068 @default.
• W1961434898 creator A5056881700 @default.
• W1961434898 creator A5077439163 @default.
• W1961434898 creator A5079770167 @default.
• W1961434898 creator A5091317490 @default.
• W1961434898 date "2015-10-16" @default.
• W1961434898 modified "2023-10-14" @default.
• W1961434898 title "Natural killer cells regulate T cell immune responses in primary biliary cirrhosis" @default.
• W1961434898 cites W1479958405 @default.
• W1961434898 cites W1492509642 @default.
• W1961434898 cites W1566270029 @default.
• W1961434898 cites W1963676215 @default.
• W1961434898 cites W1964284255 @default.
• W1961434898 cites W1970824804 @default.
• W1961434898 cites W1974756099 @default.
• W1961434898 cites W1976876579 @default.
• W1961434898 cites W1982084822 @default.
• W1961434898 cites W1989400873 @default.
• W1961434898 cites W1994502665 @default.
• W1961434898 cites W1995401008 @default.
• W1961434898 cites W1997292671 @default.
• W1961434898 cites W1998647423 @default.
• W1961434898 cites W2008706274 @default.
• W1961434898 cites W2009193187 @default.
• W1961434898 cites W2011644540 @default.
• W1961434898 cites W2013215038 @default.
• W1961434898 cites W2019481852 @default.
• W1961434898 cites W2023831900 @default.
• W1961434898 cites W2025173334 @default.
• W1961434898 cites W2032387601 @default.
• W1961434898 cites W2037039504 @default.
• W1961434898 cites W2038428454 @default.
• W1961434898 cites W2040375465 @default.
• W1961434898 cites W2051104655 @default.
• W1961434898 cites W2055420557 @default.
• W1961434898 cites W2061187116 @default.
• W1961434898 cites W2061686837 @default.
• W1961434898 cites W2061728907 @default.
• W1961434898 cites W2065738196 @default.
• W1961434898 cites W2066208025 @default.
• W1961434898 cites W2077084380 @default.
• W1961434898 cites W2083311645 @default.
• W1961434898 cites W2087287657 @default.
• W1961434898 cites W2090901622 @default.
• W1961434898 cites W2091223369 @default.
• W1961434898 cites W2100832209 @default.
• W1961434898 cites W2102713801 @default.
• W1961434898 cites W2103877699 @default.
• W1961434898 cites W2105540607 @default.
• W1961434898 cites W2119039846 @default.
• W1961434898 cites W2122267453 @default.
• W1961434898 cites W2131761283 @default.
• W1961434898 cites W2138338257 @default.
• W1961434898 cites W2149052962 @default.
• W1961434898 cites W2150724838 @default.
• W1961434898 cites W2152758419 @default.
• W1961434898 cites W2162354645 @default.
• W1961434898 cites W2171653534 @default.
• W1961434898 cites W2802290858 @default.
• W1961434898 cites W4249025813 @default.
• W1961434898 cites W4292540530 @default.
• W1961434898 doi "https://doi.org/10.1002/hep.28122" @default.
• W1961434898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4681684" @default.
• W1961434898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26264889" @default.
• W1961434898 hasPublicationYear "2015" @default.
• W1961434898 type Work @default.
• W1961434898 sameAs 1961434898 @default.
• W1961434898 citedByCount "62" @default.
• W1961434898 countsByYear W19614348982016 @default.
• W1961434898 countsByYear W19614348982017 @default.
• W1961434898 countsByYear W19614348982018 @default.
• W1961434898 countsByYear W19614348982019 @default.
• W1961434898 countsByYear W19614348982020 @default.
• W1961434898 countsByYear W19614348982021 @default.
• W1961434898 countsByYear W19614348982022 @default.
• W1961434898 countsByYear W19614348982023 @default.
• W1961434898 crossrefType "journal-article" @default.
• W1961434898 hasAuthorship W1961434898A5004420462 @default.
• W1961434898 hasAuthorship W1961434898A5008696378 @default.
• W1961434898 hasAuthorship W1961434898A5008794738 @default.
• W1961434898 hasAuthorship W1961434898A5012550681 @default.
• W1961434898 hasAuthorship W1961434898A5012890035 @default.
• W1961434898 hasAuthorship W1961434898A5016018624 @default.
• W1961434898 hasAuthorship W1961434898A5026278665 @default.
• W1961434898 hasAuthorship W1961434898A5029678899 @default.
• W1961434898 hasAuthorship W1961434898A5030939408 @default.
• W1961434898 hasAuthorship W1961434898A5037162068 @default.

• next