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- W1961503039 abstract "Objective : To analyze the cytotoxic effects of paclitaxel following introduction of the retroviral interferon- α (IFN- α) gene into epithelial ovarian cancer cells. Design : Experimental molecular study. Setting : University hospital research center. Sample: Epithelial ovarian cancer cell lines OV-2774 and SKOV3. Empty vector was used as control. Methods : The cytotoxic effects of paclitaxel on ovarian cancer cells were studied prior to and after transfection with the retrovirus-mediated inteferon- α gene. RT/PCR of the interferon gene, cell survival and cell death were analyzed to assess retroviral interferon- α gene expression after transfection. Results : Paclitaxel inhibited cell growth in a dose dependent manner with half maximal inhibitory concentration (IC50) of 7.5 ng/ml. Retroviral inteferon- α gene transfer-transduced cells potentiated paclitaxel response against both ovarian cancer cell lines by 68%. Conclusion : Retrovirus-mediated IFN- α gene transfer enhanced paclitaxel cytotoxicity on ovarian cancer cells. Retroviral IFN- α gene transfer in combination with paclitaxel may have significant clinical utility for the treatment of epithelial ovarian cancers." @default.
- W1961503039 created "2016-06-24" @default.
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- W1961503039 date "2013-03-26" @default.
- W1961503039 modified "2023-10-09" @default.
- W1961503039 title "Retroviral Interferon- α Gene Transfer Potentiates Paclitaxel against Ovarian Cancer Cells" @default.
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