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- W1961509140 endingPage "20" @default.
- W1961509140 startingPage "10" @default.
- W1961509140 abstract "Guinea pigs carry the majority of their plasma cholesterol in LDL, making them a unique animal model with which to study hepatic cholesterol and lipoprotein metabolism. In this review, the benefits and advantages of using this particular model are discussed. How dietary factors such as soluble fiber, cholesterol and fatty acids that vary in saturation and chain length affect hepatic cholesterol homeostasis and influence the synthesis, intravascular processing and catabolism of lipoproteins is reviewed. In addition, alterations in hepatic cholesterol metabolism and plasma lipoproteins as affected by treatment with cholestyramine or 3-hydroxyl-3-methylglutaryl coenzyme A reductase inhibitors, exercise, marginal intake of vitamin C, ovariectomy (a model for menopause) and similarities to the human situation are addressed. A review of guinea pigs as models for early atherosclerosis development is also presented." @default.
- W1961509140 created "2016-06-24" @default.
- W1961509140 creator A5017102102 @default.
- W1961509140 date "2001-01-01" @default.
- W1961509140 modified "2023-10-16" @default.
- W1961509140 title "Guinea Pigs as Models for Cholesterol and Lipoprotein Metabolism" @default.
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