FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1961959471> ?p ?o ?g. }

• W1961959471 endingPage "2391" @default.
• W1961959471 startingPage "2385" @default.
• W1961959471 abstract "Streptazone derivatives isolated from Streptomyces species are piperidine alkaloids with a cyclopenta[b]pyridine scaffold. Previous studies indicated that these compounds are polyketides, but the biosynthetic enzymes responsible for their synthesis are unknown. Here, we have identified the streptazone E biosynthetic gene cluster in Streptomyces sp. MSC090213JE08, which encodes a modular type I PKS and tailoring enzymes that include an aminotransferase, three oxidoreductases, and two putative cyclases. The functions of the six tailoring enzymes were analyzed by gene disruption, and two putative biosynthetic intermediates that accumulated in particular mutants were structurally elucidated. On the basis of these results, we propose a pathway for the biosynthesis of streptazone E in which the two putative cyclases of the nuclear transport factor 2–like superfamily are responsible for C−C bond formation coupled with epoxide ring opening to give the five-membered ring of streptazone E." @default.
• W1961959471 created "2016-06-24" @default.
• W1961959471 creator A5010235104 @default.
• W1961959471 creator A5031272334 @default.
• W1961959471 creator A5049459879 @default.
• W1961959471 creator A5062896803 @default.
• W1961959471 creator A5068464478 @default.
• W1961959471 creator A5077275866 @default.
• W1961959471 creator A5081284588 @default.
• W1961959471 creator A5085057723 @default.
• W1961959471 creator A5091309318 @default.
• W1961959471 date "2015-09-25" @default.
• W1961959471 modified "2023-10-02" @default.
• W1961959471 title "Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster in<i>Streptomyces</i>sp. MSC090213JE08" @default.
• W1961959471 cites W1496011245 @default.
• W1961959471 cites W1965404937 @default.
• W1961959471 cites W1967347899 @default.
• W1961959471 cites W1969153582 @default.
• W1961959471 cites W1976081343 @default.
• W1961959471 cites W2000176823 @default.
• W1961959471 cites W2009777908 @default.
• W1961959471 cites W2012892422 @default.
• W1961959471 cites W2019288201 @default.
• W1961959471 cites W2024591656 @default.
• W1961959471 cites W2035333716 @default.
• W1961959471 cites W2038638768 @default.
• W1961959471 cites W2039807208 @default.
• W1961959471 cites W2042497518 @default.
• W1961959471 cites W2044303955 @default.
• W1961959471 cites W2044734067 @default.
• W1961959471 cites W2052452786 @default.
• W1961959471 cites W2070456262 @default.
• W1961959471 cites W2091007201 @default.
• W1961959471 cites W2095223688 @default.
• W1961959471 cites W2135639274 @default.
• W1961959471 cites W2137891225 @default.
• W1961959471 cites W2140183422 @default.
• W1961959471 cites W2145974700 @default.
• W1961959471 cites W2146193735 @default.
• W1961959471 cites W2149993002 @default.
• W1961959471 cites W2174336055 @default.
• W1961959471 cites W2953092145 @default.
• W1961959471 cites W3005230657 @default.
• W1961959471 doi "https://doi.org/10.1002/cbic.201500317" @default.
• W1961959471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26403163" @default.
• W1961959471 hasPublicationYear "2015" @default.
• W1961959471 type Work @default.
• W1961959471 sameAs 1961959471 @default.
• W1961959471 citedByCount "23" @default.
• W1961959471 countsByYear W19619594712016 @default.
• W1961959471 countsByYear W19619594712017 @default.
• W1961959471 countsByYear W19619594712018 @default.
• W1961959471 countsByYear W19619594712019 @default.
• W1961959471 countsByYear W19619594712020 @default.
• W1961959471 countsByYear W19619594712021 @default.
• W1961959471 countsByYear W19619594712022 @default.
• W1961959471 countsByYear W19619594712023 @default.
• W1961959471 crossrefType "journal-article" @default.
• W1961959471 hasAuthorship W1961959471A5010235104 @default.
• W1961959471 hasAuthorship W1961959471A5031272334 @default.
• W1961959471 hasAuthorship W1961959471A5049459879 @default.
• W1961959471 hasAuthorship W1961959471A5062896803 @default.
• W1961959471 hasAuthorship W1961959471A5068464478 @default.
• W1961959471 hasAuthorship W1961959471A5077275866 @default.
• W1961959471 hasAuthorship W1961959471A5081284588 @default.
• W1961959471 hasAuthorship W1961959471A5085057723 @default.
• W1961959471 hasAuthorship W1961959471A5091309318 @default.
• W1961959471 hasConcept C104317684 @default.
• W1961959471 hasConcept C143065580 @default.
• W1961959471 hasConcept C181199279 @default.
• W1961959471 hasConcept C185592680 @default.
• W1961959471 hasConcept C2779920670 @default.
• W1961959471 hasConcept C36857842 @default.
• W1961959471 hasConcept C523546767 @default.
• W1961959471 hasConcept C54355233 @default.
• W1961959471 hasConcept C553450214 @default.
• W1961959471 hasConcept C55493867 @default.
• W1961959471 hasConcept C71240020 @default.
• W1961959471 hasConcept C86803240 @default.
• W1961959471 hasConceptScore W1961959471C104317684 @default.
• W1961959471 hasConceptScore W1961959471C143065580 @default.
• W1961959471 hasConceptScore W1961959471C181199279 @default.
• W1961959471 hasConceptScore W1961959471C185592680 @default.
• W1961959471 hasConceptScore W1961959471C2779920670 @default.
• W1961959471 hasConceptScore W1961959471C36857842 @default.
• W1961959471 hasConceptScore W1961959471C523546767 @default.
• W1961959471 hasConceptScore W1961959471C54355233 @default.
• W1961959471 hasConceptScore W1961959471C553450214 @default.
• W1961959471 hasConceptScore W1961959471C55493867 @default.
• W1961959471 hasConceptScore W1961959471C71240020 @default.
• W1961959471 hasConceptScore W1961959471C86803240 @default.
• W1961959471 hasFunder F4320320912 @default.
• W1961959471 hasFunder F4320321680 @default.
• W1961959471 hasIssue "16" @default.
• W1961959471 hasLocation W19619594711 @default.
• W1961959471 hasLocation W19619594712 @default.
• W1961959471 hasOpenAccess W1961959471 @default.
• W1961959471 hasPrimaryLocation W19619594711 @default.

• next