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- W196202204 abstract "Detailed genomic studies related to drug resistance mechanisms are now possible because of the available information on the human genome. The rapid advances in methodologies, such as microarray analysis for gene expression profiling, and the even larger choice ofmethods now developed for scoring genetic variations among populations, will have a profound impact on the way we understand health and disease. The drug resistance phenotype in human tumors is a serious setback that limits the usage of chemotherapeutic agents for treating cancers. Drug resistance in tumors may arise due to one of several mechanisms, including altered metabolism, rapid efflux, or decreased uptake. Until recently, our understanding of secondary cellular regulators/factors that contribute to drug resistance was limited due to the lack of appropriate analytical tools. Microarray and genetic polymorphism studies led to the identification and characterization of several metabolic pathways intimately linked to drug resistance. We summarize some of the recent advances in the areas of microarray and genetic polymorphisms and their relevance to health and disease in general and to drug resistance mechanisms’ in particular. Lastly, we introduce the basic premise underlying the emerging area of metabonomics and how it is relevant to drug resistance" @default.
- W196202204 created "2016-06-24" @default.
- W196202204 creator A5009144357 @default.
- W196202204 creator A5042390536 @default.
- W196202204 creator A5074419775 @default.
- W196202204 date "2002-01-01" @default.
- W196202204 modified "2023-10-01" @default.
- W196202204 title "Genomic Approaches to Clinical Drug Resistance" @default.
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