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- W1962162011 abstract "Background: We found earlier [Babarskov E. at al. ERJ 2010; 36,suppl.54:504s] that lung diffusion capacity, DL, calculated by increasing rate of integral measured CO concenration, C M , in exhaled air at successive increasing breath holding time, corresponds membrane diffusion capacity, Dm. Measurements were performed in breathing regimes, when total dead volume (instrument+anatomic), V D , was much less than respiratory volume, ΔV, at maximal alveolar volume, V A . Aim: To determine the influence of V D on C M and to estimate the relationship beetwen DL and current alveolar volume,V. Methods: Mathematical modeling of CO gas exchange in lung and experimental data analysis. Results: Two models were considered: linear model (LM) when CO gas exchange in changing V takes place at constant DL (DL=Dm), and model of elastic membrane (MEM) when DL at breathing is changed proportionally to membrane surface area and inversely to its thickness (DL=Dm*(V/V A ) 4/3 ). Calculations were performed for two different breathing regimes at equal V A =7.0 L and Dm=60 mL/min/mmHg. Spontanios breathing, when alveolar volume is changed from V 0 =3.0 L to V 1 =4.0 L at equal mean inspiration and expiration flow rate, Q=20 L/min, and deep forced breathing at V 0 =2.0 L, V 1 =7.0 L and Q=100 L/min. Both models demonstrate strong dependence of C M from V D in case of spontanios breathing, but MEM more correctly aproximates experimental data, so at increasing V D from 0 to 0.5 L, C M is decreased by 1.7 fold. Conclusion: The dependence of C M from Dm was found for different breathing regimes taking into account V D . This allows to solve inverse task - to calculate D M using known C M values." @default.
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- W1962162011 date "2013-09-01" @default.
- W1962162011 modified "2023-09-24" @default.
- W1962162011 title "Measurements of carbon monoxide (CO) in exhaled air and calculation of alveolar-capillary membrane diffusion capacity" @default.
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