FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1962293554> ?p ?o ?g. }

• W1962293554 endingPage "1719" @default.
• W1962293554 startingPage "1712" @default.
• W1962293554 abstract "Mating between the two haploid cell types (a and alpha) of the yeast Saccharomyces cerevisiae depends upon the efficient secretion and delivery of the a- and alpha-factor pheromones to their respective target cells. However, a quantitative correlation between the level of transported a-factor and mating efficiency has never been determined. a-Factor is transported by Ste6p, a member of the ATP-binding cassette (ABC) family of transporter proteins. In this study, several missense mutations were introduced in or near the conserved LSGGQ motif within the first nucleotide-binding domain of Ste6p. Quantitation of extracellular a-factor levels indicated that these mutations caused a broad range of a-factor transport defects, and those directly within the LSGGQ motif caused the most severe defects. Overall, we observed a strong correlation between the level of transported a-factor and the mating efficiency of these strains, consistent with the role of Ste6p as the a-factor transporter. The LSGGQ mutations did not cause either a significant alteration in the steady-state level of Ste6p or a detectable change in its subcellular localization. Thus, it appears that these mutations interfere with the ability of Ste6p to transport a-factor out of the MATa cell. The possible involvement of the LSGGQ motif in transporter function is consistent with the strong conservation of this sequence motif throughout the ABC transporter superfamily." @default.
• W1962293554 created "2016-06-24" @default.
• W1962293554 creator A5017216818 @default.
• W1962293554 creator A5033315508 @default.
• W1962293554 creator A5075125924 @default.
• W1962293554 date "1996-03-01" @default.
• W1962293554 modified "2023-10-17" @default.
• W1962293554 title "Mutations within the first LSGGQ motif of Ste6p cause defects in a-factor transport and mating in Saccharomyces cerevisiae" @default.
• W1962293554 cites W1019447032 @default.
• W1962293554 cites W124504601 @default.
• W1962293554 cites W131157789 @default.
• W1962293554 cites W1494357412 @default.
• W1962293554 cites W1527774170 @default.
• W1962293554 cites W1537782690 @default.
• W1962293554 cites W1547429114 @default.
• W1962293554 cites W1721292595 @default.
• W1962293554 cites W1762726625 @default.
• W1962293554 cites W1781717284 @default.
• W1962293554 cites W1819527149 @default.
• W1962293554 cites W1937262478 @default.
• W1962293554 cites W1950715156 @default.
• W1962293554 cites W1967390330 @default.
• W1962293554 cites W1973782344 @default.
• W1962293554 cites W1975971473 @default.
• W1962293554 cites W1977625601 @default.
• W1962293554 cites W1983488739 @default.
• W1962293554 cites W1985744441 @default.
• W1962293554 cites W1986682462 @default.
• W1962293554 cites W2009310436 @default.
• W1962293554 cites W2016792879 @default.
• W1962293554 cites W2028622989 @default.
• W1962293554 cites W2036931150 @default.
• W1962293554 cites W2044061221 @default.
• W1962293554 cites W2047958782 @default.
• W1962293554 cites W2061318624 @default.
• W1962293554 cites W20741063 @default.
• W1962293554 cites W2083848684 @default.
• W1962293554 cites W2091259347 @default.
• W1962293554 cites W2094020724 @default.
• W1962293554 cites W2102886871 @default.
• W1962293554 cites W2108882853 @default.
• W1962293554 cites W2110816265 @default.
• W1962293554 cites W2114400959 @default.
• W1962293554 cites W2115704794 @default.
• W1962293554 cites W2116234410 @default.
• W1962293554 cites W2120875352 @default.
• W1962293554 cites W2122448614 @default.
• W1962293554 cites W2138270253 @default.
• W1962293554 cites W2169446484 @default.
• W1962293554 cites W2176719787 @default.
• W1962293554 cites W2319504481 @default.
• W1962293554 cites W23714381 @default.
• W1962293554 cites W4248850420 @default.
• W1962293554 doi "https://doi.org/10.1128/jb.178.6.1712-1719.1996" @default.
• W1962293554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/177858" @default.
• W1962293554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8626301" @default.
• W1962293554 hasPublicationYear "1996" @default.
• W1962293554 type Work @default.
• W1962293554 sameAs 1962293554 @default.
• W1962293554 citedByCount "29" @default.
• W1962293554 countsByYear W19622935542014 @default.
• W1962293554 countsByYear W19622935542015 @default.
• W1962293554 countsByYear W19622935542018 @default.
• W1962293554 crossrefType "journal-article" @default.
• W1962293554 hasAuthorship W1962293554A5017216818 @default.
• W1962293554 hasAuthorship W1962293554A5033315508 @default.
• W1962293554 hasAuthorship W1962293554A5075125924 @default.
• W1962293554 hasBestOaLocation W19622935541 @default.
• W1962293554 hasConcept C104317684 @default.
• W1962293554 hasConcept C117745874 @default.
• W1962293554 hasConcept C149011108 @default.
• W1962293554 hasConcept C167625842 @default.
• W1962293554 hasConcept C198348125 @default.
• W1962293554 hasConcept C199216141 @default.
• W1962293554 hasConcept C2777576037 @default.
• W1962293554 hasConcept C2779222958 @default.
• W1962293554 hasConcept C28406088 @default.
• W1962293554 hasConcept C44312359 @default.
• W1962293554 hasConcept C46909000 @default.
• W1962293554 hasConcept C54355233 @default.
• W1962293554 hasConcept C86803240 @default.
• W1962293554 hasConceptScore W1962293554C104317684 @default.
• W1962293554 hasConceptScore W1962293554C117745874 @default.
• W1962293554 hasConceptScore W1962293554C149011108 @default.
• W1962293554 hasConceptScore W1962293554C167625842 @default.
• W1962293554 hasConceptScore W1962293554C198348125 @default.
• W1962293554 hasConceptScore W1962293554C199216141 @default.
• W1962293554 hasConceptScore W1962293554C2777576037 @default.
• W1962293554 hasConceptScore W1962293554C2779222958 @default.
• W1962293554 hasConceptScore W1962293554C28406088 @default.
• W1962293554 hasConceptScore W1962293554C44312359 @default.
• W1962293554 hasConceptScore W1962293554C46909000 @default.
• W1962293554 hasConceptScore W1962293554C54355233 @default.
• W1962293554 hasConceptScore W1962293554C86803240 @default.
• W1962293554 hasIssue "6" @default.
• W1962293554 hasLocation W19622935541 @default.
• W1962293554 hasLocation W19622935542 @default.
• W1962293554 hasLocation W19622935543 @default.

• next