FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1962536161> ?p ?o ?g. }

• W1962536161 endingPage "422" @default.
• W1962536161 startingPage "413" @default.
• W1962536161 abstract "ABSTRACT αβ-tubulin heterodimers self-assemble to form microtubules nucleated by γ-tubulin in the cell. γ-tubulin is believed to recruit the αβ-tubulin dimers that form the minus ends of microtubules, but the molecular mechanism of this action remains a matter of heated controversy. Still less is known about the function and molecular interactions of δ-tubulin and ε-tubulin. δ-tubulin may seed the formation of the C triplet tubules in the basal bodies of Chlamydomonas and ε-tubulin is known to localize to the centrosome in a cell cycle-dependent manner. Using the structure of αβ tubulin as a model, we have analyzed the sequences of γ-, δ- and ε-tubulin in regions corresponding to different polymerization interfaces in the tubulin αβ dimer. The sequence comparisons sometimes show clear conservation, pointing to similar types of contacts being functionally important for the new tubulin considered. Conversely, certain surfaces show marked differences that rule out equivalent interactions for non-microtubular tubulins. This sequence/structure analysis has led us to structural models of how these special tubulins may be involved in protein-protein contacts that affect microtubule self-assembly. δ-tubulin most likely interacts longitudinally with α-tubulin at the minus ends of microtubules, while ε-tubulin most likely binds to the plus end of β-tubulin. Conservation of key residues in γ-tubulin suggests that it is capable of longitudinal self-assembly. The implications for the protofilament and template models of nucleation are considered." @default.
• W1962536161 created "2016-06-24" @default.
• W1962536161 creator A5034946559 @default.
• W1962536161 creator A5057151090 @default.
• W1962536161 date "2001-01-15" @default.
• W1962536161 modified "2023-10-16" @default.
• W1962536161 title "Structural models for the self-assembly and microtubule interactions of γ-, δ- and ε-tubulin" @default.
• W1962536161 cites W1598606264 @default.
• W1962536161 cites W1881571321 @default.
• W1962536161 cites W1972909853 @default.
• W1962536161 cites W1979366788 @default.
• W1962536161 cites W1994345832 @default.
• W1962536161 cites W1996270908 @default.
• W1962536161 cites W2002603998 @default.
• W1962536161 cites W2004941701 @default.
• W1962536161 cites W2005120335 @default.
• W1962536161 cites W2012083512 @default.
• W1962536161 cites W2012550113 @default.
• W1962536161 cites W2019984193 @default.
• W1962536161 cites W2033306271 @default.
• W1962536161 cites W2058943343 @default.
• W1962536161 cites W2060802580 @default.
• W1962536161 cites W2076659391 @default.
• W1962536161 cites W2076826295 @default.
• W1962536161 cites W2085357320 @default.
• W1962536161 cites W2087463186 @default.
• W1962536161 cites W2105615050 @default.
• W1962536161 cites W2106882534 @default.
• W1962536161 cites W2106906854 @default.
• W1962536161 cites W2107229020 @default.
• W1962536161 cites W2110985101 @default.
• W1962536161 cites W2111496441 @default.
• W1962536161 cites W2117931147 @default.
• W1962536161 cites W2118562210 @default.
• W1962536161 cites W2119716967 @default.
• W1962536161 cites W2130920644 @default.
• W1962536161 cites W2132278722 @default.
• W1962536161 cites W2134850931 @default.
• W1962536161 cites W2136975961 @default.
• W1962536161 cites W2145486096 @default.
• W1962536161 cites W2162956972 @default.
• W1962536161 cites W2166082166 @default.
• W1962536161 doi "https://doi.org/10.1242/jcs.114.2.413" @default.
• W1962536161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11148142" @default.
• W1962536161 hasPublicationYear "2001" @default.
• W1962536161 type Work @default.
• W1962536161 sameAs 1962536161 @default.
• W1962536161 citedByCount "83" @default.
• W1962536161 countsByYear W19625361612012 @default.
• W1962536161 countsByYear W19625361612013 @default.
• W1962536161 countsByYear W19625361612014 @default.
• W1962536161 countsByYear W19625361612015 @default.
• W1962536161 countsByYear W19625361612016 @default.
• W1962536161 countsByYear W19625361612017 @default.
• W1962536161 countsByYear W19625361612018 @default.
• W1962536161 countsByYear W19625361612019 @default.
• W1962536161 countsByYear W19625361612020 @default.
• W1962536161 countsByYear W19625361612021 @default.
• W1962536161 countsByYear W19625361612022 @default.
• W1962536161 countsByYear W19625361612023 @default.
• W1962536161 crossrefType "journal-article" @default.
• W1962536161 hasAuthorship W1962536161A5034946559 @default.
• W1962536161 hasAuthorship W1962536161A5057151090 @default.
• W1962536161 hasConcept C10447061 @default.
• W1962536161 hasConcept C12554922 @default.
• W1962536161 hasConcept C142669718 @default.
• W1962536161 hasConcept C1491633281 @default.
• W1962536161 hasConcept C20418707 @default.
• W1962536161 hasConcept C29537977 @default.
• W1962536161 hasConcept C55493867 @default.
• W1962536161 hasConcept C61081601 @default.
• W1962536161 hasConcept C84425145 @default.
• W1962536161 hasConcept C86803240 @default.
• W1962536161 hasConcept C94921385 @default.
• W1962536161 hasConcept C95444343 @default.
• W1962536161 hasConceptScore W1962536161C10447061 @default.
• W1962536161 hasConceptScore W1962536161C12554922 @default.
• W1962536161 hasConceptScore W1962536161C142669718 @default.
• W1962536161 hasConceptScore W1962536161C1491633281 @default.
• W1962536161 hasConceptScore W1962536161C20418707 @default.
• W1962536161 hasConceptScore W1962536161C29537977 @default.
• W1962536161 hasConceptScore W1962536161C55493867 @default.
• W1962536161 hasConceptScore W1962536161C61081601 @default.
• W1962536161 hasConceptScore W1962536161C84425145 @default.
• W1962536161 hasConceptScore W1962536161C86803240 @default.
• W1962536161 hasConceptScore W1962536161C94921385 @default.
• W1962536161 hasConceptScore W1962536161C95444343 @default.
• W1962536161 hasIssue "2" @default.
• W1962536161 hasLocation W19625361611 @default.
• W1962536161 hasLocation W19625361612 @default.
• W1962536161 hasOpenAccess W1962536161 @default.
• W1962536161 hasPrimaryLocation W19625361611 @default.
• W1962536161 hasRelatedWork W1901412126 @default.
• W1962536161 hasRelatedWork W1974089612 @default.
• W1962536161 hasRelatedWork W2024145976 @default.
• W1962536161 hasRelatedWork W2031263977 @default.
• W1962536161 hasRelatedWork W2070191397 @default.
• W1962536161 hasRelatedWork W2079016385 @default.

• next