FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1962581036> ?p ?o ?g. }

• W1962581036 endingPage "23" @default.
• W1962581036 startingPage "1017" @default.
• W1962581036 abstract "The purpose of the present study was to determine the effects of muscarinic cholinergic receptor antagonists and agonists on prepulse inhibition (PPI) of the acoustic startle reflex in rats. The muscarinic receptor antagonist scopolamine (0.03-1.0 mg/kg) produced a significant dose-dependent decrease in PPI without affecting startle amplitude. In contrast, N-methyl scopolamine, the quaternary analog of scopolamine, had no effect on PPI, indicating that scopolamine disrupted PPI through a central cholinergic mechanism. Two other muscarinic receptor antagonists, trihexyphenidyl (0.3-10 mg/kg) and benztropine (0.03-10 mg/kg), produced significant decreases in PPI similar to scopolamine. On the other hand, the muscarinic receptor antagonists dicyclomine (0.03-10 mg/kg) and biperiden (0.03-10 mg/kg) had no effect on PPI but significantly decreased startle amplitude. Mecamylamine (0.1-10 mg/kg), a nicotinic receptor antagonist, also had no effect on PPI. Administered alone, the muscarinic receptor agonists pilocarpine (0. 03-10 mg/kg), oxotremorine (0.01-0.3 mg/kg), RS-86 (0.1-3.0 mg/kg), and arecoline (0.3-10 mg/kg), as well as the cholinesterase inhibitors physostigmine (0.01-0.3 mg/kg) and tacrine (0.03-10 mg/kg), had no effect on PPI, but each produced significant decreases in startle amplitude at the highest doses tested. In addition, the disruption of PPI by scopolamine was reversed in a dose-dependent manner by the muscarinic receptor agonist oxotremorine. The present findings demonstrate that the muscarinic cholinergic system plays an important role in the normal mechanisms of PPI." @default.
• W1962581036 created "2016-06-24" @default.
• W1962581036 creator A5051209585 @default.
• W1962581036 creator A5065902063 @default.
• W1962581036 date "2000-09-01" @default.
• W1962581036 modified "2023-09-29" @default.
• W1962581036 title "Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex." @default.
• W1962581036 cites W1828770259 @default.
• W1962581036 cites W1878271255 @default.
• W1962581036 cites W1914438944 @default.
• W1962581036 cites W1958815412 @default.
• W1962581036 cites W1966069671 @default.
• W1962581036 cites W1971715733 @default.
• W1962581036 cites W1973585598 @default.
• W1962581036 cites W1979151871 @default.
• W1962581036 cites W1983282595 @default.
• W1962581036 cites W2013333342 @default.
• W1962581036 cites W2015531992 @default.
• W1962581036 cites W2021280501 @default.
• W1962581036 cites W2023875149 @default.
• W1962581036 cites W2025821577 @default.
• W1962581036 cites W2029277771 @default.
• W1962581036 cites W2030626220 @default.
• W1962581036 cites W2032741928 @default.
• W1962581036 cites W2037001477 @default.
• W1962581036 cites W2038439835 @default.
• W1962581036 cites W2040340862 @default.
• W1962581036 cites W2040761578 @default.
• W1962581036 cites W2048403879 @default.
• W1962581036 cites W2060163004 @default.
• W1962581036 cites W2066315102 @default.
• W1962581036 cites W2067418199 @default.
• W1962581036 cites W2073279884 @default.
• W1962581036 cites W2074940164 @default.
• W1962581036 cites W2080781505 @default.
• W1962581036 cites W2097759310 @default.
• W1962581036 cites W2114563409 @default.
• W1962581036 cites W2187766730 @default.
• W1962581036 cites W2400901825 @default.
• W1962581036 cites W2069517777 @default.
• W1962581036 cites W2479128429 @default.
• W1962581036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10945854" @default.
• W1962581036 hasPublicationYear "2000" @default.
• W1962581036 type Work @default.
• W1962581036 sameAs 1962581036 @default.
• W1962581036 citedByCount "44" @default.
• W1962581036 countsByYear W19625810362012 @default.
• W1962581036 countsByYear W19625810362014 @default.
• W1962581036 countsByYear W19625810362015 @default.
• W1962581036 countsByYear W19625810362016 @default.
• W1962581036 countsByYear W19625810362017 @default.
• W1962581036 countsByYear W19625810362018 @default.
• W1962581036 countsByYear W19625810362020 @default.
• W1962581036 countsByYear W19625810362021 @default.
• W1962581036 countsByYear W19625810362023 @default.
• W1962581036 crossrefType "journal-article" @default.
• W1962581036 hasAuthorship W1962581036A5051209585 @default.
• W1962581036 hasAuthorship W1962581036A5065902063 @default.
• W1962581036 hasConcept C126322002 @default.
• W1962581036 hasConcept C134018914 @default.
• W1962581036 hasConcept C170493617 @default.
• W1962581036 hasConcept C185592680 @default.
• W1962581036 hasConcept C207723603 @default.
• W1962581036 hasConcept C2776723954 @default.
• W1962581036 hasConcept C2778616617 @default.
• W1962581036 hasConcept C2778824757 @default.
• W1962581036 hasConcept C2779406339 @default.
• W1962581036 hasConcept C33789571 @default.
• W1962581036 hasConcept C47488739 @default.
• W1962581036 hasConcept C64123433 @default.
• W1962581036 hasConcept C71924100 @default.
• W1962581036 hasConcept C98274493 @default.
• W1962581036 hasConceptScore W1962581036C126322002 @default.
• W1962581036 hasConceptScore W1962581036C134018914 @default.
• W1962581036 hasConceptScore W1962581036C170493617 @default.
• W1962581036 hasConceptScore W1962581036C185592680 @default.
• W1962581036 hasConceptScore W1962581036C207723603 @default.
• W1962581036 hasConceptScore W1962581036C2776723954 @default.
• W1962581036 hasConceptScore W1962581036C2778616617 @default.
• W1962581036 hasConceptScore W1962581036C2778824757 @default.
• W1962581036 hasConceptScore W1962581036C2779406339 @default.
• W1962581036 hasConceptScore W1962581036C33789571 @default.
• W1962581036 hasConceptScore W1962581036C47488739 @default.
• W1962581036 hasConceptScore W1962581036C64123433 @default.
• W1962581036 hasConceptScore W1962581036C71924100 @default.
• W1962581036 hasConceptScore W1962581036C98274493 @default.
• W1962581036 hasIssue "3" @default.
• W1962581036 hasLocation W19625810361 @default.
• W1962581036 hasOpenAccess W1962581036 @default.
• W1962581036 hasPrimaryLocation W19625810361 @default.
• W1962581036 hasRelatedWork W1009201231 @default.
• W1962581036 hasRelatedWork W1962581036 @default.
• W1962581036 hasRelatedWork W1967694651 @default.
• W1962581036 hasRelatedWork W1970357364 @default.
• W1962581036 hasRelatedWork W2050608994 @default.
• W1962581036 hasRelatedWork W2063471656 @default.
• W1962581036 hasRelatedWork W2187141558 @default.
• W1962581036 hasRelatedWork W2293792387 @default.

• next