Matches in SemOpenAlex for { <https://semopenalex.org/work/W1962767585> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1962767585 startingPage "1771" @default.
- W1962767585 abstract "Introduction: The Wnt signaling pathways may be involved in the development of idiopathic pulmonary fibrosis (IPF). Wnt has been demonstrated to down-regulate the expression of CCAAT enhancer-binding protein α (C/EBPα), and the pro-fibrotic cytokines transforming growth factor-β (TGF-β) and endothelin-1 (ET-1) are controlled by Wnt3a signaling. Aim: To study the effect of TGF-β and ET-1 on ECM production and Wnt expression in primary human IPF fibroblasts. Methods: Fibroblasts were isolated from IPF lungs (n=4) and from non-fibrotic controls (n=4). After stimulation with TGF- β1 and/or ET-1, ECM was measured by ELISA. Total protein was harvested and immuno blot analysis was performed. Results: TGF-β (0.5 – 10 ng/ml) dose dependently increased total ECM deposition by 180%. ET-1 alone (0.5 – 10 ng/ml) had no effect on ECM. When combined, ET-1 super-induced the TGF-β-effect in a synergistic manner. Expression of Wnt3a was up-regulated by TGF-β in IPF fibroblasts whereas no effect was seen after ET-1 treatment. When ET-1 was added together with TGF-β, Wnt3a expression was further enhanced in comparison to TGF-β alone. Expression of Wnt3a was weak in control fibroblasts, and no induction by ET-1/TGF-β was observed. Expression of total C/EBPα in IPF fibroblasts was lower than in controls. Conclusions: In IPF fibroblasts, ET-1 exerted its pro-fibrotic effect only in the presence of TGF-β, and a similar interconnection was observed for the up-regulation of Wnt3a expression. This suggests a disease-specific and interdependent pro-fibrotic effect of ET-1 and TGF-β, which might be mediated via the up-regulation of Wnt3a and the down-regulation of the C/EBPα." @default.
- W1962767585 created "2016-06-24" @default.
- W1962767585 creator A5020466456 @default.
- W1962767585 creator A5021433705 @default.
- W1962767585 creator A5058581441 @default.
- W1962767585 creator A5067952145 @default.
- W1962767585 creator A5077426550 @default.
- W1962767585 date "2012-09-01" @default.
- W1962767585 modified "2023-09-22" @default.
- W1962767585 title "Interdependence of endothelin-1 and transforming growth factor-β1 on Wnt3a expression in idiopathic pulmonary fibrosis" @default.
- W1962767585 hasPublicationYear "2012" @default.
- W1962767585 type Work @default.
- W1962767585 sameAs 1962767585 @default.
- W1962767585 citedByCount "0" @default.
- W1962767585 crossrefType "journal-article" @default.
- W1962767585 hasAuthorship W1962767585A5020466456 @default.
- W1962767585 hasAuthorship W1962767585A5021433705 @default.
- W1962767585 hasAuthorship W1962767585A5058581441 @default.
- W1962767585 hasAuthorship W1962767585A5067952145 @default.
- W1962767585 hasAuthorship W1962767585A5077426550 @default.
- W1962767585 hasConcept C104317684 @default.
- W1962767585 hasConcept C118131993 @default.
- W1962767585 hasConcept C126322002 @default.
- W1962767585 hasConcept C137620995 @default.
- W1962767585 hasConcept C149601957 @default.
- W1962767585 hasConcept C170493617 @default.
- W1962767585 hasConcept C2776415932 @default.
- W1962767585 hasConcept C2777714996 @default.
- W1962767585 hasConcept C2778341716 @default.
- W1962767585 hasConcept C2779131293 @default.
- W1962767585 hasConcept C2780559512 @default.
- W1962767585 hasConcept C2781244666 @default.
- W1962767585 hasConcept C502942594 @default.
- W1962767585 hasConcept C55493867 @default.
- W1962767585 hasConcept C62478195 @default.
- W1962767585 hasConcept C71924100 @default.
- W1962767585 hasConcept C86803240 @default.
- W1962767585 hasConcept C95444343 @default.
- W1962767585 hasConceptScore W1962767585C104317684 @default.
- W1962767585 hasConceptScore W1962767585C118131993 @default.
- W1962767585 hasConceptScore W1962767585C126322002 @default.
- W1962767585 hasConceptScore W1962767585C137620995 @default.
- W1962767585 hasConceptScore W1962767585C149601957 @default.
- W1962767585 hasConceptScore W1962767585C170493617 @default.
- W1962767585 hasConceptScore W1962767585C2776415932 @default.
- W1962767585 hasConceptScore W1962767585C2777714996 @default.
- W1962767585 hasConceptScore W1962767585C2778341716 @default.
- W1962767585 hasConceptScore W1962767585C2779131293 @default.
- W1962767585 hasConceptScore W1962767585C2780559512 @default.
- W1962767585 hasConceptScore W1962767585C2781244666 @default.
- W1962767585 hasConceptScore W1962767585C502942594 @default.
- W1962767585 hasConceptScore W1962767585C55493867 @default.
- W1962767585 hasConceptScore W1962767585C62478195 @default.
- W1962767585 hasConceptScore W1962767585C71924100 @default.
- W1962767585 hasConceptScore W1962767585C86803240 @default.
- W1962767585 hasConceptScore W1962767585C95444343 @default.
- W1962767585 hasOpenAccess W1962767585 @default.
- W1962767585 hasRelatedWork W1479708684 @default.
- W1962767585 hasRelatedWork W1925032259 @default.
- W1962767585 hasRelatedWork W1967223294 @default.
- W1962767585 hasRelatedWork W1973073024 @default.
- W1962767585 hasRelatedWork W1989410388 @default.
- W1962767585 hasRelatedWork W2005566723 @default.
- W1962767585 hasRelatedWork W2089812656 @default.
- W1962767585 hasRelatedWork W2098478885 @default.
- W1962767585 hasRelatedWork W2188858576 @default.
- W1962767585 hasRelatedWork W2227800545 @default.
- W1962767585 hasRelatedWork W2550296122 @default.
- W1962767585 hasRelatedWork W2611093490 @default.
- W1962767585 hasRelatedWork W2779811736 @default.
- W1962767585 hasRelatedWork W2900897704 @default.
- W1962767585 hasRelatedWork W2946744779 @default.
- W1962767585 hasRelatedWork W2972626908 @default.
- W1962767585 hasRelatedWork W3028960503 @default.
- W1962767585 hasRelatedWork W3185045079 @default.
- W1962767585 hasRelatedWork W3206533861 @default.
- W1962767585 hasRelatedWork W1887302432 @default.
- W1962767585 hasVolume "40" @default.
- W1962767585 isParatext "false" @default.
- W1962767585 isRetracted "false" @default.
- W1962767585 magId "1962767585" @default.
- W1962767585 workType "article" @default.