FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1962777897> ?p ?o ?g. }

• W1962777897 abstract "Background Prolotherapy involves repeated injections of irritant solutions to strengthen lumbosacral ligaments and reduce some types of chronic low‐back pain; spinal manipulation and exercises are often used to enhance its effectiveness. Objectives To determine the efficacy of prolotherapy in adults with chronic low‐back pain. Search methods We searched CENTRAL 2006, Issue 3 and MEDLINE, EMBASE, CINAHL, and AMED from their respective beginnings to October 2006, with no restrictions on language, and consulted content experts. Literature search was updated on July 29th, 2009. No new RCTs were identified. Selection criteria We included randomised (RCT) and quasi‐randomised controlled trials (QRCT) that compared prolotherapy injections to control injections, alone or in combination with other treatments, which measured pain or disability before and after the intervention. Data collection and analysis Two review authors independently selected the trials and assessed methodological quality. Intervention protocols varied from study to study, making meta‐analysis impossible. Main results We identified five high quality studies with a total of 366 participants. All measured pain or disability levels at six months, and four measured the proportion of participants reporting a greater than 50% reduction in pain or disability scores. Three randomised controlled trials (206 participants) found that prolotherapy injections alone are no more effective than control injection for chronic low‐back pain and disability. At six months, there was no difference between groups in mean pain or disability scores (2 RCTs; 184 participants) and no difference in proportions who reported over 50% improvement in pain or disability (3 RCTs; 206 participants). These trials could not be pooled due to clinical heterogeneity. Two RCTs (160 participants) found that prolotherapy injections, given with spinal manipulation, exercise, and other therapies, are more effective than control injections for chronic low‐back pain and disability. At six months, one study reported a significant difference between groups in mean pain and disability scores, whereas the other study did not. Both studies reported a significant difference in the proportion of individuals who reported over 50% reduction in disability or pain. Co‐interventions confounded interpretation of results and clinical heterogeneity in the trials prevented pooling. Authors' conclusions There is conflicting evidence regarding the efficacy of prolotherapy injections for patients with chronic low‐back pain. When used alone, prolotherapy is not an effective treatment for chronic low‐back pain. When combined with spinal manipulation, exercise, and other co‐interventions, prolotherapy may improve chronic low‐back pain and disability. Conclusions are confounded by clinical heterogeneity amongst studies and by the presence of co‐interventions." @default.
• W1962777897 created "2016-06-24" @default.
• W1962777897 creator A5021292619 @default.
• W1962777897 creator A5046358429 @default.
• W1962777897 creator A5062701846 @default.
• W1962777897 creator A5088016987 @default.
• W1962777897 creator A5090390097 @default.
• W1962777897 date "2007-04-18" @default.
• W1962777897 modified "2023-10-04" @default.
• W1962777897 title "Prolotherapy injections for chronic low-back pain" @default.
• W1962777897 cites W1531353720 @default.
• W1962777897 cites W1585122557 @default.
• W1962777897 cites W1962777897 @default.
• W1962777897 cites W1986309799 @default.
• W1962777897 cites W1990349880 @default.
• W1962777897 cites W2002300955 @default.
• W1962777897 cites W2004769253 @default.
• W1962777897 cites W2007392572 @default.
• W1962777897 cites W2020239842 @default.
• W1962777897 cites W2037377025 @default.
• W1962777897 cites W2046548607 @default.
• W1962777897 cites W2057086126 @default.
• W1962777897 cites W2064296154 @default.
• W1962777897 cites W2067689995 @default.
• W1962777897 cites W2074064333 @default.
• W1962777897 cites W2097809720 @default.
• W1962777897 cites W2099785572 @default.
• W1962777897 cites W2118516436 @default.
• W1962777897 cites W2138407894 @default.
• W1962777897 cites W2145513209 @default.
• W1962777897 cites W2172151487 @default.
• W1962777897 cites W2277462455 @default.
• W1962777897 cites W2473786944 @default.
• W1962777897 cites W4292806894 @default.
• W1962777897 cites W4327847545 @default.
• W1962777897 doi "https://doi.org/10.1002/14651858.cd004059.pub3" @default.
• W1962777897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6986690" @default.
• W1962777897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17443537" @default.
• W1962777897 hasPublicationYear "2007" @default.
• W1962777897 type Work @default.
• W1962777897 sameAs 1962777897 @default.
• W1962777897 citedByCount "72" @default.
• W1962777897 countsByYear W19627778972012 @default.
• W1962777897 countsByYear W19627778972013 @default.
• W1962777897 countsByYear W19627778972014 @default.
• W1962777897 countsByYear W19627778972015 @default.
• W1962777897 countsByYear W19627778972016 @default.
• W1962777897 countsByYear W19627778972017 @default.
• W1962777897 countsByYear W19627778972018 @default.
• W1962777897 countsByYear W19627778972019 @default.
• W1962777897 countsByYear W19627778972021 @default.
• W1962777897 countsByYear W19627778972022 @default.
• W1962777897 countsByYear W19627778972023 @default.
• W1962777897 crossrefType "journal-article" @default.
• W1962777897 hasAuthorship W1962777897A5021292619 @default.
• W1962777897 hasAuthorship W1962777897A5046358429 @default.
• W1962777897 hasAuthorship W1962777897A5062701846 @default.
• W1962777897 hasAuthorship W1962777897A5088016987 @default.
• W1962777897 hasAuthorship W1962777897A5090390097 @default.
• W1962777897 hasBestOaLocation W19627778972 @default.
• W1962777897 hasConcept C141071460 @default.
• W1962777897 hasConcept C142724271 @default.
• W1962777897 hasConcept C159110408 @default.
• W1962777897 hasConcept C168563851 @default.
• W1962777897 hasConcept C1862650 @default.
• W1962777897 hasConcept C204787440 @default.
• W1962777897 hasConcept C27415008 @default.
• W1962777897 hasConcept C2780145008 @default.
• W1962777897 hasConcept C2780907711 @default.
• W1962777897 hasConcept C2781145037 @default.
• W1962777897 hasConcept C7146039 @default.
• W1962777897 hasConcept C71924100 @default.
• W1962777897 hasConceptScore W1962777897C141071460 @default.
• W1962777897 hasConceptScore W1962777897C142724271 @default.
• W1962777897 hasConceptScore W1962777897C159110408 @default.
• W1962777897 hasConceptScore W1962777897C168563851 @default.
• W1962777897 hasConceptScore W1962777897C1862650 @default.
• W1962777897 hasConceptScore W1962777897C204787440 @default.
• W1962777897 hasConceptScore W1962777897C27415008 @default.
• W1962777897 hasConceptScore W1962777897C2780145008 @default.
• W1962777897 hasConceptScore W1962777897C2780907711 @default.
• W1962777897 hasConceptScore W1962777897C2781145037 @default.
• W1962777897 hasConceptScore W1962777897C7146039 @default.
• W1962777897 hasConceptScore W1962777897C71924100 @default.
• W1962777897 hasLocation W19627778971 @default.
• W1962777897 hasLocation W19627778972 @default.
• W1962777897 hasLocation W19627778973 @default.
• W1962777897 hasLocation W19627778974 @default.
• W1962777897 hasLocation W19627778975 @default.
• W1962777897 hasOpenAccess W1962777897 @default.
• W1962777897 hasPrimaryLocation W19627778971 @default.
• W1962777897 hasRelatedWork W1604448167 @default.
• W1962777897 hasRelatedWork W2005680150 @default.
• W1962777897 hasRelatedWork W2057958745 @default.
• W1962777897 hasRelatedWork W2121102496 @default.
• W1962777897 hasRelatedWork W2136763556 @default.
• W1962777897 hasRelatedWork W2163914023 @default.
• W1962777897 hasRelatedWork W3152916031 @default.
• W1962777897 hasRelatedWork W4210557340 @default.
• W1962777897 hasRelatedWork W4226056541 @default.

• next