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• W1962779685 startingPage "1347" @default.
• W1962779685 abstract "High-resolution microscopy using fluorescent probes is a powerful tool to investigate individual cell structure and function, cell subpopulations and mechanisms underlying cellular responses to drugs. Additionally, responses to drugs more closely resemble those seen in vivo when cells are physically connected in three-dimensional (3D) systems (either 3D cell cultures or whole organisms), as opposed to traditional monolayer cultures. Combined, the use of imaging-based 3D models in the early stages of drug development has the potential to generate biologically relevant data that will increase the likelihood of success for drug candidates in human studies.The authors discuss current methods for the culturing of cells in 3D as well as approaches for the imaging of whole-animal models and 3D cultures that are amenable to high-throughput settings and could be implemented to support drug discovery campaigns. Furthermore, they provide critical considerations when discussing imaging these 3D systems for high-throughput chemical screenings.Despite widespread understanding of the limitations imposed by the two-dimensional versus the 3D cellular paradigm, imaging-based drug screening of 3D cellular models is still limited, with only a few screens found in the literature. Image acquisition in high throughput, accurate interpretation of fluorescent signal, and uptake of staining reagents can be challenging, as the samples are in essence large aggregates of cells. The authors recognize these shortcomings that need to be overcome before the field can accelerate the utilization of these technologies in large-scale chemical screens." @default.
• W1962779685 created "2016-06-24" @default.
• W1962779685 creator A5059969497 @default.
• W1962779685 creator A5067942165 @default.
• W1962779685 creator A5079873012 @default.
• W1962779685 creator A5079961784 @default.
• W1962779685 date "2015-09-22" @default.
• W1962779685 modified "2023-10-17" @default.
• W1962779685 title "High-throughput fluorescence imaging approaches for drug discovery using<i>in vitro</i>and<i>in vivo</i>three-dimensional models" @default.
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