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• W1962855849 abstract "Cytokines are crucial for the regulation of inflammation development in humans. Many studies have shown that variations in cytokine genes might play a role in determining human longevity. This study examined the changes in the gene pool relevant to the -308 G/A polymorphism in the promoter region of the proinflammatory cytokine tumour necrosis factor (TNF)-alpha gene and the -1082 G/A polymorphism in the promoter region of anti-inflammatory cytokine interleukin (IL)-10 gene with aging and survival selection occurs in the Jordanian population. IL-10 -1028 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years. No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05) while the IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05). Thus, IL-10 -1028 G/A polymorphism seems to play a role in the pathway to longevity in Jordanian men." @default.
• W1962855849 created "2016-06-24" @default.
• W1962855849 creator A5049884448 @default.
• W1962855849 creator A5060733023 @default.
• W1962855849 date "2010-04-30" @default.
• W1962855849 modified "2023-09-27" @default.
• W1962855849 title "Association of longevity with IL-10 −1082 G/A and TNF-α−308 G/A polymorphisms" @default.
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• W1962855849 doi "https://doi.org/10.1111/j.1744-313x.2010.00925.x" @default.
• W1962855849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20518833" @default.
• W1962855849 hasPublicationYear "2010" @default.
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