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• W1963014952 abstract "We aimed to evaluate the histologic and radiologic findings of vascular lesions after stereotactic radiosurgery (SRS) categorized as radiation-induced cavernous hemangioma (RICH).Among 89 patients who underwent neurosurgery for cavernous hemangioma, eight RICHs from 7 patients and 10 de novo CHs from 10 patients were selected for histopathological and radiological comparison.Histologically, RICHs showed hematoma-like gross appearance. Microscopically, RICH exhibited a hematoma-like area accompanied by proliferation of thin-walled vasculature with fibrin deposits and infiltrating foamy macrophages. In contrast, CHs demonstrated localized malformed vasculature containing fresh and old clotted blood on gross examination. Typically, CHs consisted of thick, ectatic hyalinized vessels lined by endothelium under a light microscope. Magnetic resonance imaging of RICHs revealed some overlapping but distinct features with CHs, including enhancing cystic and solid components with absence or incomplete popcorn-like appearance and partial hemosiderin rims.Together with histologic and radiologic findings, RICH may result from blood-filled space after tissue destruction by SRS, accompanied with radiation-induced reactive changes rather than vascular malformation. Thus, the term RICH would be inappropriate, because it is more likely to be an inactive organizing hematoma rather than proliferation of malformed vasculature." @default.
• W1963014952 created "2016-06-24" @default.
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• W1963014952 date "2015-01-01" @default.
• W1963014952 modified "2023-09-23" @default.
• W1963014952 title "Pathological Evaluation of Radiation-Induced Vascular Lesions of the Brain: Distinct from<i>De Novo</i>Cavernous Hemangioma" @default.
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• W1963014952 doi "https://doi.org/10.3349/ymj.2015.56.6.1714" @default.
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