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- W1963245505 abstract "Background Arterial hypertension is common after renaltransplantation (Tx) and is present in about 70–90% kidneytransplant recipients. It is one of major nonimmunologicrisk factors that directly relate to patient andgraft survivals. There are variety of causes that lead to hypertensionafter renal Tx: dependent on transplantedkidney, on native kidneys and related to immunosuppressivetherapy. The choice of hypotensive drug depends notonly on its possible impact on renal graft but also on thepharmacological interference with immunosuppressivemedicines. The aim of the study was to assess blood pressurecontrol in kidney transplant recipients. Material and methods The retrospective analysis of 190(mean age 50 y) patients — 54% male and 46% female wasmade based on the medical documentation. The medicalhistory, BP measurements twice a visit during three visits,laboratory tests (including cyclosporine level) were taken.The kind of hypotensive and immunosuppressive drugsand the connection between the number and kind of themand BP control was analyzed. Results Hypertension was present in 78% patients (n =149). Mean blood pressure (BP) was 129.76 ± 12.76/79.3± 8.7 mm Hg. The study cohort was divided according toBP: group I (62 persons — 33%) with mean BP ≥ 140//90 mm Hg, group II (128 persons) — with BP β -blocker (38.5%, n = 64), then Cablocker(28.7%, n = 48) and ACEI (24.5%, n = 41). Patientswith uncontrolled BP used diuretics more often (9%,n = 4 v. 0.9%, n = 1, respectively; p = 0.011). The mediannumber of antihypertensive agents used by one patient was1; 55 patients (29%) were treated with no hypotensive drugand 1 patient used 4 drugs. BP was significantly higher inthe males comparing to females (133.45 ± 10.57/81.21 ±7.19 v. 125.46 ± 14.25/76.98 ± 9.8 mm Hg, respectively)(p Conclusions Hypertension is a common finding in kidneytransplant recipient. More than 1/3 of study population, especiallythose with shorter time after Tx, had abnormal BPbased on office BP measurement. ABPM should be used todetect masked and hidden uncontrolled hypertension in thispopulation. Too less hypotensive drug was used, particularlyRAS blockers. More aggressive antihypertensive treatmentusing combined drugs, including RAS blocker, wouldprovide adequate BP control in study cohort including kidneytransplant recipients with high cardiovascular risk. Arterial Hypertension 2011, vol. 15, no 5, pages 283–289" @default.
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- W1963245505 date "2011-01-01" @default.
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- W1963245505 title "Blood pressure control in kidney transplant recipients" @default.
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