Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963417458> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1963417458 endingPage "405" @default.
- W1963417458 startingPage "399" @default.
- W1963417458 abstract "A novel, rapid and sensitive liquid chromatography/quadrupole linear ion trap mass spectrometry [LC-ESI-(QqLIT)MS/MS] method was developed and validated for the quantification of protopanaxadiol (PPD) in rat plasma. Oleanolic acid (OA) was used as internal standard (IS). A simple protein precipitation based on acetonitrile (ACN) was employed. Chromatographic separation was performed on a Sepax GP-C18 column (50 × 2.1 mm, 5 μM) with a mobile phase consisting of ACN-water and 1.5 μM formic acid and 25 mM lithium acetate (90 : 10, v/v) at a flow rate of 0.4 ml/min for 3.0 min. Multiple-reaction-monitoring mode was performed using lithium adduct ion as precursor ion of m/z 467.5/449.4 and 455.6/407.4 for the drug and IS, respectively. Calibration curve was recovered over a concentration range of 0.5-100 ng/ml with a correlation coefficient >0.99. The limit of detection was 0.2 ng/ml in rat plasma for PPD. The results of the intraday and interday precision and accuracy studies were well within the acceptable limits. The validated method was successfully applied to investigate the pharmacokinetic study of PPD after intravenous and gavage administration to rat." @default.
- W1963417458 created "2016-06-24" @default.
- W1963417458 creator A5021762426 @default.
- W1963417458 creator A5041266048 @default.
- W1963417458 creator A5052800839 @default.
- W1963417458 date "2013-03-01" @default.
- W1963417458 modified "2023-10-08" @default.
- W1963417458 title "Lithium adduct as precursor ion for sensitive and rapid quantification of 20 (<i>S</i>)-protopanaxadiol in rat plasma by liquid chromatography/quadrupole linear ion trap mass spectrometry and application to rat pharmacokinetic study" @default.
- W1963417458 cites W1975081844 @default.
- W1963417458 cites W1984053258 @default.
- W1963417458 cites W1990232984 @default.
- W1963417458 cites W1998768133 @default.
- W1963417458 cites W2001473305 @default.
- W1963417458 cites W2020380758 @default.
- W1963417458 cites W2020543511 @default.
- W1963417458 cites W2023339504 @default.
- W1963417458 cites W2035954001 @default.
- W1963417458 cites W2036467698 @default.
- W1963417458 cites W2043368637 @default.
- W1963417458 cites W2046401757 @default.
- W1963417458 cites W2047131453 @default.
- W1963417458 cites W2055048861 @default.
- W1963417458 cites W2061014596 @default.
- W1963417458 cites W2064665896 @default.
- W1963417458 cites W2108255861 @default.
- W1963417458 cites W2153524297 @default.
- W1963417458 doi "https://doi.org/10.1002/jms.3174" @default.
- W1963417458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23494798" @default.
- W1963417458 hasPublicationYear "2013" @default.
- W1963417458 type Work @default.
- W1963417458 sameAs 1963417458 @default.
- W1963417458 citedByCount "10" @default.
- W1963417458 countsByYear W19634174582014 @default.
- W1963417458 countsByYear W19634174582015 @default.
- W1963417458 countsByYear W19634174582016 @default.
- W1963417458 countsByYear W19634174582018 @default.
- W1963417458 countsByYear W19634174582020 @default.
- W1963417458 countsByYear W19634174582021 @default.
- W1963417458 countsByYear W19634174582022 @default.
- W1963417458 crossrefType "journal-article" @default.
- W1963417458 hasAuthorship W1963417458A5021762426 @default.
- W1963417458 hasAuthorship W1963417458A5041266048 @default.
- W1963417458 hasAuthorship W1963417458A5052800839 @default.
- W1963417458 hasConcept C106289968 @default.
- W1963417458 hasConcept C113196181 @default.
- W1963417458 hasConcept C119128265 @default.
- W1963417458 hasConcept C162356407 @default.
- W1963417458 hasConcept C185592680 @default.
- W1963417458 hasConcept C23531484 @default.
- W1963417458 hasConcept C2777379063 @default.
- W1963417458 hasConcept C27826464 @default.
- W1963417458 hasConcept C31827203 @default.
- W1963417458 hasConcept C40684141 @default.
- W1963417458 hasConcept C43617362 @default.
- W1963417458 hasConcept C71043704 @default.
- W1963417458 hasConcept C74774607 @default.
- W1963417458 hasConceptScore W1963417458C106289968 @default.
- W1963417458 hasConceptScore W1963417458C113196181 @default.
- W1963417458 hasConceptScore W1963417458C119128265 @default.
- W1963417458 hasConceptScore W1963417458C162356407 @default.
- W1963417458 hasConceptScore W1963417458C185592680 @default.
- W1963417458 hasConceptScore W1963417458C23531484 @default.
- W1963417458 hasConceptScore W1963417458C2777379063 @default.
- W1963417458 hasConceptScore W1963417458C27826464 @default.
- W1963417458 hasConceptScore W1963417458C31827203 @default.
- W1963417458 hasConceptScore W1963417458C40684141 @default.
- W1963417458 hasConceptScore W1963417458C43617362 @default.
- W1963417458 hasConceptScore W1963417458C71043704 @default.
- W1963417458 hasConceptScore W1963417458C74774607 @default.
- W1963417458 hasIssue "3" @default.
- W1963417458 hasLocation W19634174581 @default.
- W1963417458 hasLocation W19634174582 @default.
- W1963417458 hasOpenAccess W1963417458 @default.
- W1963417458 hasPrimaryLocation W19634174581 @default.
- W1963417458 hasRelatedWork W2018203908 @default.
- W1963417458 hasRelatedWork W2027234736 @default.
- W1963417458 hasRelatedWork W2037207885 @default.
- W1963417458 hasRelatedWork W2062882792 @default.
- W1963417458 hasRelatedWork W2077253723 @default.
- W1963417458 hasRelatedWork W2078286064 @default.
- W1963417458 hasRelatedWork W2120161408 @default.
- W1963417458 hasRelatedWork W2167226854 @default.
- W1963417458 hasRelatedWork W2404291284 @default.
- W1963417458 hasRelatedWork W284217049 @default.
- W1963417458 hasVolume "48" @default.
- W1963417458 isParatext "false" @default.
- W1963417458 isRetracted "false" @default.
- W1963417458 magId "1963417458" @default.
- W1963417458 workType "article" @default.