Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963441572> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W1963441572 endingPage "118.18" @default.
- W1963441572 startingPage "118.18" @default.
- W1963441572 abstract "Abstract RSV bronchiolitis is an important cause of pediatric hospitalization, which often leads to developing asthma in later life. Studies have indicated a Th2 skewed polarization of the lung environment in these children, which can be modulated by exogenous administration of osteopontin (OPN). In this study, using an NKT cell KO (CD1d-/-) mouse model, we have examined the effects of OPN on macrophages (MQ) and T lymphocytes (Tc) during RSV infection and identified the role of NKT cells in this process. Flowcytometry analysis determined that OPN treatment in RSV infection had reduced MQ and Tc recruitment in the lung parenchyma and alveolar spaces. However, OPN induced activation of the CD4 and CD8 Tcs in an NKT- dependent fashion, as the magnitude of activation was reduced to only 20% in the CD1d-/- mice as compared to the wild type (WT) mice. Also, expression of MHCII on MQs was significantly increased in the CD1d-/- mice, indicating a downregulatory effect of NKT cells. Altogether, these data suggest that OPN differentially affects MQ and Tc response and their functional modulations in an NKT cell-dependent fashion. A better understanding of these inverse effects of OPN on different immune effector cells during RSV infection may help establish OPN as a potential therapeutic for prevention of RSV-associated asthma in children." @default.
- W1963441572 created "2016-06-24" @default.
- W1963441572 creator A5041934392 @default.
- W1963441572 creator A5044195931 @default.
- W1963441572 creator A5058672523 @default.
- W1963441572 creator A5059178758 @default.
- W1963441572 date "2014-05-01" @default.
- W1963441572 modified "2023-10-14" @default.
- W1963441572 title "NKT cell-dependent differential effects of OPN on functional modulation of macrophages and T lymphocytes in RSV infection (HYP6P.273)" @default.
- W1963441572 doi "https://doi.org/10.4049/jimmunol.192.supp.118.18" @default.
- W1963441572 hasPublicationYear "2014" @default.
- W1963441572 type Work @default.
- W1963441572 sameAs 1963441572 @default.
- W1963441572 citedByCount "0" @default.
- W1963441572 crossrefType "journal-article" @default.
- W1963441572 hasAuthorship W1963441572A5041934392 @default.
- W1963441572 hasAuthorship W1963441572A5044195931 @default.
- W1963441572 hasAuthorship W1963441572A5058672523 @default.
- W1963441572 hasAuthorship W1963441572A5059178758 @default.
- W1963441572 hasConcept C139563560 @default.
- W1963441572 hasConcept C167672396 @default.
- W1963441572 hasConcept C203014093 @default.
- W1963441572 hasConcept C2778607024 @default.
- W1963441572 hasConcept C2780804394 @default.
- W1963441572 hasConcept C86803240 @default.
- W1963441572 hasConcept C8891405 @default.
- W1963441572 hasConceptScore W1963441572C139563560 @default.
- W1963441572 hasConceptScore W1963441572C167672396 @default.
- W1963441572 hasConceptScore W1963441572C203014093 @default.
- W1963441572 hasConceptScore W1963441572C2778607024 @default.
- W1963441572 hasConceptScore W1963441572C2780804394 @default.
- W1963441572 hasConceptScore W1963441572C86803240 @default.
- W1963441572 hasConceptScore W1963441572C8891405 @default.
- W1963441572 hasIssue "1_Supplement" @default.
- W1963441572 hasLocation W19634415721 @default.
- W1963441572 hasOpenAccess W1963441572 @default.
- W1963441572 hasPrimaryLocation W19634415721 @default.
- W1963441572 hasRelatedWork W17784216 @default.
- W1963441572 hasRelatedWork W2042235665 @default.
- W1963441572 hasRelatedWork W2052793100 @default.
- W1963441572 hasRelatedWork W2060027536 @default.
- W1963441572 hasRelatedWork W2095967285 @default.
- W1963441572 hasRelatedWork W2150316436 @default.
- W1963441572 hasRelatedWork W2154075447 @default.
- W1963441572 hasRelatedWork W2345552044 @default.
- W1963441572 hasRelatedWork W2921443070 @default.
- W1963441572 hasRelatedWork W29274827 @default.
- W1963441572 hasVolume "192" @default.
- W1963441572 isParatext "false" @default.
- W1963441572 isRetracted "false" @default.
- W1963441572 magId "1963441572" @default.
- W1963441572 workType "article" @default.