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• W1963485603 abstract "C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and LI 210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentrationdependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis." @default.
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• W1963485603 date "1990-01-01" @default.
• W1963485603 modified "2023-10-11" @default.
• W1963485603 title "Mechanism of action of a new macromolecular antitumor antibiotic, C-1027." @default.
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• W1963485603 doi "https://doi.org/10.7164/antibiotics.43.417" @default.
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