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• W1963497046 abstract "Experimental, clinical, and epidemiologic studies indicate that non-steroidal anti-inflammatory drugs (NSAIDs) are beneficial in Alzheimer's disease and other neuroinflammatory processes. One possible mechanism is an interaction with peroxisome proliferator-activated receptors (PPARs). We examined the effect of a specific PPARγ agonist, rosiglitazone, on contextual fear conditioning in aged rats. Male rats (20-months-old) were administered rosiglitazone in the diet for 2 months prior to behavioral testing. Young control and aged rats fed rosiglitazone froze significantly more than did the aged control rats in a hippocampal-dependent fear conditioning task. Rosiglitazone had no effect hippocampal interleukin-1β levels, markers of oxidative damage, and NMDA receptor expression. Therefore, activation of PPARγ prevented age-related deficits in hippocampal function." @default.
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• W1963497046 date "2004-10-01" @default.
• W1963497046 modified "2023-10-16" @default.
• W1963497046 title "Rosiglitazone improves contextual fear conditioning in aged rats" @default.
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• W1963497046 doi "https://doi.org/10.1097/00001756-200410050-00023" @default.
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