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- W1963500218 abstract "The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally related genes reside preferentially in mutationally hot or cold regions, the size of which we have measured. Genes in hot regions are biased toward extracellular communication (surface receptors, cell adhesion, immune response, etc.), while those in cold regions are biased toward essential cellular processes (gene regulation, RNA processing, protein modification, etc.). From a selective perspective, this organization of genes could minimize the mutational load on genes that need to be conserved and allow fast evolution for genes that must frequently adapt. We also analyze the effect of gene duplication and chromosomal recombination, which contribute significantly to these biases for certain categories of hot genes. Overall, our results show that genes are located nonrandomly with respect to hot and cold regions, offering the possibility that selection acts at the level of gene location in the human genome." @default.
- W1963500218 created "2016-06-24" @default.
- W1963500218 creator A5019560977 @default.
- W1963500218 creator A5078627287 @default.
- W1963500218 date "2004-02-17" @default.
- W1963500218 modified "2023-09-26" @default.
- W1963500218 title "Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions in the Human Genome" @default.
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- W1963500218 doi "https://doi.org/10.1371/journal.pbio.0020029" @default.
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