Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963500709> ?p ?o ?g. }
- W1963500709 endingPage "527" @default.
- W1963500709 startingPage "519" @default.
- W1963500709 abstract "A rat dementia model with cognitive deficits was generated by synapse-specific lesions using botulinum neurotoxin (BoNTx) type B in the entorhinal cortex. To detect cognitive deficits, different tasks were needed depending upon the age of the model animals. Impaired learning and memory with lesions were observed in adult rats using the Hebb-Williams maze, AKON-1 maze and a continuous alternation task in T-maze. Cognitive deficits in lesioned aged rats were detected by a continuous alternation and delayed non-matching-to-sample tasks in T-maze. Adenovirus-mediated BDNF gene expression enhanced neuronal plasticity, as revealed by behavioral tests and LTP formation. Chronic administration of carnitine over time pre- and post-lesions seemed to partially ameliorate the cognitive deficits caused by the synaptic lesion. The carnitine-accelerated recovery from synaptic damage was observed by electron microscopy. These results demonstrate that the BoNTx-lesioned rat can be used as a model for dementia and that cognitive deficits can be alleviated in part by BDNF gene transfer or carnitine administration. © 2002 Wiley-Liss, Inc." @default.
- W1963500709 created "2016-06-24" @default.
- W1963500709 creator A5003255362 @default.
- W1963500709 creator A5027714270 @default.
- W1963500709 creator A5036731453 @default.
- W1963500709 creator A5058750262 @default.
- W1963500709 creator A5061818588 @default.
- W1963500709 creator A5069931207 @default.
- W1963500709 creator A5074161751 @default.
- W1963500709 creator A5085897151 @default.
- W1963500709 creator A5086343918 @default.
- W1963500709 creator A5087848723 @default.
- W1963500709 creator A5090907927 @default.
- W1963500709 date "2002-10-18" @default.
- W1963500709 modified "2023-10-01" @default.
- W1963500709 title "Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine" @default.
- W1963500709 cites W1536306056 @default.
- W1963500709 cites W1565095682 @default.
- W1963500709 cites W1601172323 @default.
- W1963500709 cites W1606564954 @default.
- W1963500709 cites W1761549107 @default.
- W1963500709 cites W1967696997 @default.
- W1963500709 cites W1974837569 @default.
- W1963500709 cites W1975079608 @default.
- W1963500709 cites W1976915575 @default.
- W1963500709 cites W1977153638 @default.
- W1963500709 cites W1979364057 @default.
- W1963500709 cites W1979709992 @default.
- W1963500709 cites W1981250359 @default.
- W1963500709 cites W1982257600 @default.
- W1963500709 cites W1986852072 @default.
- W1963500709 cites W1987638083 @default.
- W1963500709 cites W1989389324 @default.
- W1963500709 cites W1990064667 @default.
- W1963500709 cites W1990752558 @default.
- W1963500709 cites W1993623475 @default.
- W1963500709 cites W2004782459 @default.
- W1963500709 cites W2011969090 @default.
- W1963500709 cites W2012220782 @default.
- W1963500709 cites W2017297492 @default.
- W1963500709 cites W2021667186 @default.
- W1963500709 cites W2023831571 @default.
- W1963500709 cites W2024626366 @default.
- W1963500709 cites W202555250 @default.
- W1963500709 cites W2026566599 @default.
- W1963500709 cites W2031293980 @default.
- W1963500709 cites W2032673357 @default.
- W1963500709 cites W2033500343 @default.
- W1963500709 cites W2034716956 @default.
- W1963500709 cites W2035771895 @default.
- W1963500709 cites W2037062825 @default.
- W1963500709 cites W2037230449 @default.
- W1963500709 cites W2044136923 @default.
- W1963500709 cites W2047776513 @default.
- W1963500709 cites W2048800757 @default.
- W1963500709 cites W2049144486 @default.
- W1963500709 cites W2052340581 @default.
- W1963500709 cites W2054704859 @default.
- W1963500709 cites W2056123459 @default.
- W1963500709 cites W2057961619 @default.
- W1963500709 cites W2062491059 @default.
- W1963500709 cites W2064394313 @default.
- W1963500709 cites W2064925227 @default.
- W1963500709 cites W2067430815 @default.
- W1963500709 cites W2070040981 @default.
- W1963500709 cites W2071390704 @default.
- W1963500709 cites W2071732139 @default.
- W1963500709 cites W2074468913 @default.
- W1963500709 cites W2078328650 @default.
- W1963500709 cites W2086231230 @default.
- W1963500709 cites W2086490904 @default.
- W1963500709 cites W2093488421 @default.
- W1963500709 cites W2099102233 @default.
- W1963500709 cites W2116001892 @default.
- W1963500709 cites W2117640165 @default.
- W1963500709 cites W2118958148 @default.
- W1963500709 cites W2153547750 @default.
- W1963500709 cites W2155934086 @default.
- W1963500709 cites W2303373200 @default.
- W1963500709 cites W2444048247 @default.
- W1963500709 cites W2016629426 @default.
- W1963500709 doi "https://doi.org/10.1002/jnr.10443" @default.
- W1963500709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12391613" @default.
- W1963500709 hasPublicationYear "2002" @default.
- W1963500709 type Work @default.
- W1963500709 sameAs 1963500709 @default.
- W1963500709 citedByCount "91" @default.
- W1963500709 countsByYear W19635007092012 @default.
- W1963500709 countsByYear W19635007092013 @default.
- W1963500709 countsByYear W19635007092014 @default.
- W1963500709 countsByYear W19635007092015 @default.
- W1963500709 countsByYear W19635007092016 @default.
- W1963500709 countsByYear W19635007092017 @default.
- W1963500709 countsByYear W19635007092018 @default.
- W1963500709 countsByYear W19635007092019 @default.
- W1963500709 countsByYear W19635007092020 @default.
- W1963500709 countsByYear W19635007092021 @default.
- W1963500709 countsByYear W19635007092022 @default.