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• W1963511279 abstract "The rise of the NGF mRNA pool which takes place following exposure of L‐929 fibroblasts to serum was prevented in the presence of 5 μM K‐252a, a compound which inhibits several species of protein kinase activities. To characterize further this phenomenon, L‐929 cells growing in a serum‐free medium were exposed to cyclic nucleotide analogs, to a divalent cation ionophore or to the phorbol ester PMA. Only this latter compound induced an enhancement of the NGF mRNA pool, suggesting an involvement of protein kinase C in the upregulation of the NGF transcripts. The effects of PMA or serum also require a synthesis of protein since the level of NGF transcripts remained stable in the presence of cycloheximide." @default.
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• W1963511279 date "1990-03-12" @default.
• W1963511279 modified "2023-10-05" @default.
• W1963511279 title "Phorbol 12-myristate 13-acetate (PMA) increases the expression of the nerve growth factor (NGF) gene in mouse L-929 fibroblasts" @default.
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• W1963511279 doi "https://doi.org/10.1016/0014-5793(90)80149-d" @default.
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