Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963513161> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1963513161 endingPage "15" @default.
- W1963513161 startingPage "15" @default.
- W1963513161 abstract "Background: The overall goal of this study is to use a bacterial toxin as drug delivery agents for chemotherapy drugs and overcome the development of resistance to these medicines. COR-L105 and MDA-MB 231 which are epithelial-like were used in this study. Cytotoxicity assays were performed by 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) as metabolic indicator. The toxin was essential to kill 50% (CT50) and IC50 value (inhibition growth value) for methotrexate were determined as optical density at 540 nm. Epsilon toxin-loaded PLGA nanoparticles were prepared using non-aqueous technique. Surface morphology, in vitro drug release, and encapsulation efficiency of the nanoparticles was determined. Results: Results confirmed that using non-toxic concentration of epsilon toxin, resistance to cancerous cell decreased significantly, which could be an important result in cancer therapy. The synergistic effect of MTX and epsilon toxin showed that bio toxins can be used as supplement with chemical drugs and increase the effect of chemotherapy. The results illustrated that application of PLGA as drug delivery system due to its controlled release properties was beneficial. Conclusion: These finding proposed that due to the ease of local accessibility of lung tumors with aerosol drug delivery, biotoxins can directly be used with chemotherapy drugs in aerosol form." @default.
- W1963513161 created "2016-06-24" @default.
- W1963513161 creator A5004181045 @default.
- W1963513161 creator A5025728368 @default.
- W1963513161 creator A5029731625 @default.
- W1963513161 creator A5073887483 @default.
- W1963513161 date "2014-01-01" @default.
- W1963513161 modified "2023-09-25" @default.
- W1963513161 title "The investigation of epsilon toxin effects on different cancerous cell lines and its synergism effect with methotrexate" @default.
- W1963513161 cites W2035978552 @default.
- W1963513161 doi "https://doi.org/10.4103/0973-1482.131338" @default.
- W1963513161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24762480" @default.
- W1963513161 hasPublicationYear "2014" @default.
- W1963513161 type Work @default.
- W1963513161 sameAs 1963513161 @default.
- W1963513161 citedByCount "2" @default.
- W1963513161 countsByYear W19635131612014 @default.
- W1963513161 crossrefType "journal-article" @default.
- W1963513161 hasAuthorship W1963513161A5004181045 @default.
- W1963513161 hasAuthorship W1963513161A5025728368 @default.
- W1963513161 hasAuthorship W1963513161A5029731625 @default.
- W1963513161 hasAuthorship W1963513161A5073887483 @default.
- W1963513161 hasBestOaLocation W19635131611 @default.
- W1963513161 hasConcept C109316439 @default.
- W1963513161 hasConcept C126322002 @default.
- W1963513161 hasConcept C178790620 @default.
- W1963513161 hasConcept C185592680 @default.
- W1963513161 hasConcept C202751555 @default.
- W1963513161 hasConcept C203014093 @default.
- W1963513161 hasConcept C2776694085 @default.
- W1963513161 hasConcept C2777367657 @default.
- W1963513161 hasConcept C2777752497 @default.
- W1963513161 hasConcept C2779820397 @default.
- W1963513161 hasConcept C2780035454 @default.
- W1963513161 hasConcept C2780783641 @default.
- W1963513161 hasConcept C2781059491 @default.
- W1963513161 hasConcept C29730261 @default.
- W1963513161 hasConcept C55493867 @default.
- W1963513161 hasConcept C71924100 @default.
- W1963513161 hasConcept C98274493 @default.
- W1963513161 hasConceptScore W1963513161C109316439 @default.
- W1963513161 hasConceptScore W1963513161C126322002 @default.
- W1963513161 hasConceptScore W1963513161C178790620 @default.
- W1963513161 hasConceptScore W1963513161C185592680 @default.
- W1963513161 hasConceptScore W1963513161C202751555 @default.
- W1963513161 hasConceptScore W1963513161C203014093 @default.
- W1963513161 hasConceptScore W1963513161C2776694085 @default.
- W1963513161 hasConceptScore W1963513161C2777367657 @default.
- W1963513161 hasConceptScore W1963513161C2777752497 @default.
- W1963513161 hasConceptScore W1963513161C2779820397 @default.
- W1963513161 hasConceptScore W1963513161C2780035454 @default.
- W1963513161 hasConceptScore W1963513161C2780783641 @default.
- W1963513161 hasConceptScore W1963513161C2781059491 @default.
- W1963513161 hasConceptScore W1963513161C29730261 @default.
- W1963513161 hasConceptScore W1963513161C55493867 @default.
- W1963513161 hasConceptScore W1963513161C71924100 @default.
- W1963513161 hasConceptScore W1963513161C98274493 @default.
- W1963513161 hasIssue "1" @default.
- W1963513161 hasLocation W19635131611 @default.
- W1963513161 hasLocation W19635131612 @default.
- W1963513161 hasOpenAccess W1963513161 @default.
- W1963513161 hasPrimaryLocation W19635131611 @default.
- W1963513161 hasRelatedWork W1592261125 @default.
- W1963513161 hasRelatedWork W1988639501 @default.
- W1963513161 hasRelatedWork W2002842018 @default.
- W1963513161 hasRelatedWork W2027887203 @default.
- W1963513161 hasRelatedWork W2032014397 @default.
- W1963513161 hasRelatedWork W2365360638 @default.
- W1963513161 hasRelatedWork W2621300768 @default.
- W1963513161 hasRelatedWork W2768098903 @default.
- W1963513161 hasRelatedWork W2893864608 @default.
- W1963513161 hasRelatedWork W4296642737 @default.
- W1963513161 hasVolume "10" @default.
- W1963513161 isParatext "false" @default.
- W1963513161 isRetracted "false" @default.
- W1963513161 magId "1963513161" @default.
- W1963513161 workType "article" @default.