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- W1963513249 abstract "It was shown previously that α-MSH levels in peripheral blood of rats subjected to passive avoidance training did not correlate with the behavioral performance of the animals. We have investigated whether α-MSH levels in cerebrospinal fluid (CSF) change during passive avoidance behavior. It appeared that throughout adaptation, acquisition and retention of this avoidance behavior, α-MSH levels in the CSF did not change significantly. In an additional experiment in which the effects of an electric footshock versus a psychological stimulus were tested, α-MSH levels in CSF also remained unchanged. Since CSF α-MSH levels appear to be relatively stable under these behavioral conditions, it seems unlikely that the CSF functions as a direct and specific route for the afferent transport of the behaviorally active neuropeptide α-MSH to its sites of action in the brain. However, the psychological stimulus, which consisted of the fear of receiving an unavoidable electric footshock, did induce a significant enhancement of α-MSH levels in peripheral blood, suggesting that psychological stress may be involved in the release of α-MSH into the peripheral circulation. These results support the idea of a differentiated system of secretion of α-MSH into CSF and peripheral blood." @default.
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- W1963513249 date "1982-05-01" @default.
- W1963513249 modified "2023-09-26" @default.
- W1963513249 title "α-MSH levels in cerebrospinal fluid and blood of rats during behavioral manipulations" @default.
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- W1963513249 doi "https://doi.org/10.1016/0031-9384(82)90191-3" @default.
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