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• W1963515616 abstract "Atherosclerosis is a progressive disease involving the formation of fatty plaques that thicken the coronary artery wall and result in reduced blood flow. The disease was formerly considered to be a lipid-storage disorder, however, extensive studies over the last decade suggest that inflammation plays a pathogenic role in atherogenesis [ 1 Ridker P.M. Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view. Blood Coagul Fibrinol. 1999; S1: 9-12 Google Scholar , 2 Robbie L. Libby P. Inflammation and atherothrombosis. Ann NY Acad Sci USA. 2001; 947: 167-179 Crossref PubMed Scopus (87) Google Scholar , 3 Mulvihill N.T. Foley J.B. Inflammation in acute coronary syndromes. Heart. 2002; 87: 201-204 Crossref PubMed Scopus (132) Google Scholar , 4 Libby P. Ridker P.M. Maseri A. Inflammation and atherosclerosis. Circulation. 2002; 105: 1135-1143 Crossref PubMed Scopus (5842) Google Scholar ]. Evidence for this theory has largely been generated from the studies of lesion-localized leukocytes in atherogenesis. Recent evidence suggests that systemic inflammation may also play a role in atherosclerosis. For example, atherosclerotic plasma directly activates endothelium for leukocyte migration [ 5 Wiedermann C.J. Schratzberger P. Dunzendorfer S. Kiechl S. Reinisch N. Kahler C.M. et al. Human and bovine endothelial cell monolayers are differentially activated for neutrophil transmigration by human plasma. Ann NY Acad Sci USA. 1997; 832: 135-146 Crossref PubMed Scopus (7) Google Scholar , 6 Schratzberger P. Kiechl S. Dunzendorfer S. Kahler C.M. Patsch J.R. Willeit J. et al. Plasma-induced endothelial activation associated with incident atherosclerosis: prospective results from the Bruneck Study. J Cardiovasc Risk. 2000; 7: 285-291 PubMed Google Scholar ], suggesting that plasma proteins may play a role in atherogenesis. In addition, C-reactive protein (CRP), an acute-phase protein present in the serum, has been considered as a risk marker of coronary disease [ 7 Ma A. The role of C-reactive protein in cardiovascular disease risk. Curr Cardiol Rep. 2000; 2: 274-279 Crossref PubMed Scopus (25) Google Scholar , 8 Jialal I. Devaraj S. Inflammation and atherosclerosis: the value of the high-sensitivity C-reactive protein assay as a risk marker. Am. J Clin Pathol. 2001; 116: S108-S115 PubMed Google Scholar , 9 Benzaquen L.R. Yu H. Rifai N. High sensitivity C-reactive protein: an emerging role in cardiovascular risk assessment. Crit Rev Clin Lab Sci. 2002; 39: 459-497 Crossref PubMed Scopus (53) Google Scholar ]." @default.
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• W1963515616 title "Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease" @default.
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