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- W1963516612 abstract "Letters1 January 1981Mitotane and Low Thyroxine LevelsALAN SACERDOTE, M.D., NARINDER M. KUKAR, M.D., SHELDON J. BLEICHER, M.D., ANASTASIO HERRERA, M.D., FELIPE JUBAY JR., M.D.ALAN SACERDOTE, M.D.Search for more papers by this author, NARINDER M. KUKAR, M.D.Search for more papers by this author, SHELDON J. BLEICHER, M.D.Search for more papers by this author, ANASTASIO HERRERA, M.D.Search for more papers by this author, FELIPE JUBAY JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-1-141 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the recently published article Sustained Remission of Cushing's Disease with Mitotane and Pituitary Irradiation by Schteingart and colleagues (1). We take exception to one point in their generally excellent report and analysis. They suggest that low thyroxine (T4) levels in mitotane-treated patients could be due to competitive binding of mitotane to thyroxine-binding globulin in the competitive protein binding assay.We wish to point out, first, that there would be no free mitotane in the patients' serum to interfere with the assay unless blood for T4 levels were drawn almost immediately after a dose....Reference1. SCHTEINGARTTSAOTAYLORMCKENZIEVICTORIATHERRIEN DHCARB. Sustained remission of Cushing's disease with mitotane and pituitary irradiation. Ann Intern Med. 1980;92:613-9. LinkGoogle Scholar1. MARSHALLTOMKINS JL. Effect of op'DDD and similar compounds on thyroxine-binding globulin. J Clin Endocrinol Metab. 1968;28:386-92. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Brooklyn Hospital Brooklyn, NY 11201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMetabolic and Endocrine Toxicities of Mitotane: A Systematic ReviewMitotane treatment in patients with adrenocortical cancer causes central hypothyroidismA six month mitotane course induced sustained correction of hypercortisolism in a young woman with PPNAD and Carney complex 1 January 1981Volume 94, Issue 1Page: 141-141KeywordsBloodGlobulinsProteinsThyroxine Issue Published: 1 January 1981 PDF DownloadLoading ..." @default.
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- W1963516612 title "Mitotane and Low Thyroxine Levels" @default.
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