Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963518531> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1963518531 endingPage "43" @default.
- W1963518531 startingPage "35" @default.
- W1963518531 abstract "Ganley, L., Babu, S., and Rajan, T. V. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and −/− mice. Experimental Parasitology98, 35–43. Previous results from our laboratory using pharmacological approaches suggested a role for nitric oxide (NO) in the host defense against the human filarial parasite, Brugia malayi. We sought to determine whether a complementary genetic approach, using mice homozygous for a targeted mutation in the gene encoding inducible nitric oxide-synthase (NOS2), would confirm our observation. We hypothesized that such mice would exhibit some deficit in their ability to clear B. malayi. Our data show that the course of infection in NOS2−/− mice is the same as in wild-type mice. Thus, peritoneal cellular responses to infection are similar in NOS2−/− and wild-type mice, with the exception that T cells form a higher percentage of total peritoneal cells in the former. We find virtually no serum IgE in NOS2−/− mice, suggesting a less robust Th2 response. In contrast, NOS2−/− mice demonstrate an early rise in IgG2a titers compared to B6 +/+ mice. Our data suggest that NO is not an obligate requirement for the elimination of B. malayi from the peritoneal cavities of mice." @default.
- W1963518531 created "2016-06-24" @default.
- W1963518531 creator A5065087689 @default.
- W1963518531 creator A5076550138 @default.
- W1963518531 creator A5077213465 @default.
- W1963518531 date "2001-05-01" @default.
- W1963518531 modified "2023-09-25" @default.
- W1963518531 title "Course of Brugia malayi Infection in C57BL/6J NOS2 +/+ and −/− Mice" @default.
- W1963518531 cites W1488731849 @default.
- W1963518531 cites W1664456366 @default.
- W1963518531 cites W1979483810 @default.
- W1963518531 cites W1991484350 @default.
- W1963518531 cites W1997441466 @default.
- W1963518531 cites W2008084875 @default.
- W1963518531 cites W2023170094 @default.
- W1963518531 cites W2029187140 @default.
- W1963518531 cites W2030140262 @default.
- W1963518531 cites W2042448187 @default.
- W1963518531 cites W2046748289 @default.
- W1963518531 cites W2047062139 @default.
- W1963518531 cites W2050482677 @default.
- W1963518531 cites W2057025197 @default.
- W1963518531 cites W2063680573 @default.
- W1963518531 cites W2072510856 @default.
- W1963518531 cites W2081485204 @default.
- W1963518531 cites W2114387788 @default.
- W1963518531 cites W2114610899 @default.
- W1963518531 cites W2120240287 @default.
- W1963518531 cites W2120918432 @default.
- W1963518531 cites W2126926648 @default.
- W1963518531 cites W2129514426 @default.
- W1963518531 cites W2141268794 @default.
- W1963518531 cites W2166519885 @default.
- W1963518531 cites W4248084213 @default.
- W1963518531 doi "https://doi.org/10.1006/expr.2001.4611" @default.
- W1963518531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11426950" @default.
- W1963518531 hasPublicationYear "2001" @default.
- W1963518531 type Work @default.
- W1963518531 sameAs 1963518531 @default.
- W1963518531 citedByCount "14" @default.
- W1963518531 countsByYear W19635185312014 @default.
- W1963518531 countsByYear W19635185312019 @default.
- W1963518531 crossrefType "journal-article" @default.
- W1963518531 hasAuthorship W1963518531A5065087689 @default.
- W1963518531 hasAuthorship W1963518531A5076550138 @default.
- W1963518531 hasAuthorship W1963518531A5077213465 @default.
- W1963518531 hasConcept C153911025 @default.
- W1963518531 hasConcept C159047783 @default.
- W1963518531 hasConcept C165901193 @default.
- W1963518531 hasConcept C203014093 @default.
- W1963518531 hasConcept C2775848585 @default.
- W1963518531 hasConcept C2777629521 @default.
- W1963518531 hasConcept C86803240 @default.
- W1963518531 hasConceptScore W1963518531C153911025 @default.
- W1963518531 hasConceptScore W1963518531C159047783 @default.
- W1963518531 hasConceptScore W1963518531C165901193 @default.
- W1963518531 hasConceptScore W1963518531C203014093 @default.
- W1963518531 hasConceptScore W1963518531C2775848585 @default.
- W1963518531 hasConceptScore W1963518531C2777629521 @default.
- W1963518531 hasConceptScore W1963518531C86803240 @default.
- W1963518531 hasIssue "1" @default.
- W1963518531 hasLocation W19635185311 @default.
- W1963518531 hasLocation W19635185312 @default.
- W1963518531 hasOpenAccess W1963518531 @default.
- W1963518531 hasPrimaryLocation W19635185311 @default.
- W1963518531 hasRelatedWork W1487857142 @default.
- W1963518531 hasRelatedWork W1702322095 @default.
- W1963518531 hasRelatedWork W1865764402 @default.
- W1963518531 hasRelatedWork W1974653828 @default.
- W1963518531 hasRelatedWork W1975114493 @default.
- W1963518531 hasRelatedWork W2014655359 @default.
- W1963518531 hasRelatedWork W2118087741 @default.
- W1963518531 hasRelatedWork W2333413219 @default.
- W1963518531 hasRelatedWork W2474689416 @default.
- W1963518531 hasRelatedWork W2801302808 @default.
- W1963518531 hasVolume "98" @default.
- W1963518531 isParatext "false" @default.
- W1963518531 isRetracted "false" @default.
- W1963518531 magId "1963518531" @default.
- W1963518531 workType "article" @default.