FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963522904> ?p ?o ?g. }

• W1963522904 endingPage "S75" @default.
• W1963522904 startingPage "S69" @default.
• W1963522904 abstract "Topical prostaglandins (PGs) are very effective at reducing intraocular pressure (IOP) in a variety of animals and in humans with relatively few side effects. The mechanisms of action of several PGs, their prodrugs and analogues have been studied in rabbits, cats, monkeys and humans. PGF2 alpha and its analogues evaluated in monkeys include PGF2 alpha-tromethamine salt, PGF2 alpha -isopropylester (-IE), S-1033, PhXA34, PhDH100A and latanoprost (PhXA41). Aqueous flow and outflow facility are either increased or remain unchanged by these agents. PGF2 alpha-IE, PHXA34, PhDH100A and latanoprost increase uveoscleral outflow, accounting for most of the IOP reduction. PGA2 in cats increases aqueous flow and outflow facility, but it reduces IOP primarily by stimulating uveoscleral outflow. The PGD2 analogue BW245C is unique in that it is the only PG that decreases aqueous flow. Mechanistic studies in humans have been performed with PGF2 alpha -IE, unoprostone, PhXA34 and latanoprost. In two clinical studies with latanoprost, a significant increase in uveoscleral outflow was found which, as in animals, accounts for most of the IOP reduction. A slight but inconsistent increase in outflow facility may also be involved. The doses tested had minimal effects on the permeability of the blood-aqueous barrier (BAB). In vitro studies of human tissue have been conducted to elucidate the PG effect on outflow facility and uveoscleral outflow. Studies of isolated human anterior segment preparations show that PGE2 increases outflow facility whereas PGF2 alpha has no measurable effect on this parameter. Studies of human ciliary muscle cells in tissue culture indicate that PGs may directly modulate extracellular matrix metabolism, which may be related to the increased uveoscleral drainage. This review summarizes in vitro and in vivo studies of the effects of PGs on aqueous humor dynamics and BAB integrity in humans, cats and monkeys." @default.
• W1963522904 created "2016-06-24" @default.
• W1963522904 creator A5014045477 @default.
• W1963522904 creator A5020308050 @default.
• W1963522904 creator A5039302002 @default.
• W1963522904 creator A5091104086 @default.
• W1963522904 date "1997-02-01" @default.
• W1963522904 modified "2023-10-02" @default.
• W1963522904 title "Effects of exogenous prostaglandins on aqueous humor dynamics and blood-aqueous barrier function" @default.
• W1963522904 cites W1979275309 @default.
• W1963522904 cites W1983891072 @default.
• W1963522904 cites W1999776257 @default.
• W1963522904 cites W2001191546 @default.
• W1963522904 cites W2006726419 @default.
• W1963522904 cites W2011654693 @default.
• W1963522904 cites W2027796183 @default.
• W1963522904 cites W2030251743 @default.
• W1963522904 cites W2035868519 @default.
• W1963522904 cites W2040344985 @default.
• W1963522904 cites W2041085670 @default.
• W1963522904 cites W2056597240 @default.
• W1963522904 cites W2058214122 @default.
• W1963522904 cites W2059589670 @default.
• W1963522904 cites W2066098313 @default.
• W1963522904 cites W2071559840 @default.
• W1963522904 cites W2072776920 @default.
• W1963522904 cites W2080504583 @default.
• W1963522904 cites W2125107554 @default.
• W1963522904 cites W2133102141 @default.
• W1963522904 cites W2135124962 @default.
• W1963522904 cites W2161265937 @default.
• W1963522904 cites W2169498049 @default.
• W1963522904 doi "https://doi.org/10.1016/s0039-6257(97)80010-0" @default.
• W1963522904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9154279" @default.
• W1963522904 hasPublicationYear "1997" @default.
• W1963522904 type Work @default.
• W1963522904 sameAs 1963522904 @default.
• W1963522904 citedByCount "106" @default.
• W1963522904 countsByYear W19635229042012 @default.
• W1963522904 countsByYear W19635229042014 @default.
• W1963522904 countsByYear W19635229042015 @default.
• W1963522904 countsByYear W19635229042016 @default.
• W1963522904 countsByYear W19635229042017 @default.
• W1963522904 countsByYear W19635229042018 @default.
• W1963522904 countsByYear W19635229042019 @default.
• W1963522904 countsByYear W19635229042020 @default.
• W1963522904 countsByYear W19635229042021 @default.
• W1963522904 countsByYear W19635229042022 @default.
• W1963522904 countsByYear W19635229042023 @default.
• W1963522904 crossrefType "journal-article" @default.
• W1963522904 hasAuthorship W1963522904A5014045477 @default.
• W1963522904 hasAuthorship W1963522904A5020308050 @default.
• W1963522904 hasAuthorship W1963522904A5039302002 @default.
• W1963522904 hasAuthorship W1963522904A5091104086 @default.
• W1963522904 hasConcept C118487528 @default.
• W1963522904 hasConcept C121332964 @default.
• W1963522904 hasConcept C126322002 @default.
• W1963522904 hasConcept C134018914 @default.
• W1963522904 hasConcept C141071460 @default.
• W1963522904 hasConcept C153294291 @default.
• W1963522904 hasConcept C185592680 @default.
• W1963522904 hasConcept C2775944032 @default.
• W1963522904 hasConcept C2776740260 @default.
• W1963522904 hasConcept C2779904517 @default.
• W1963522904 hasConcept C2780664492 @default.
• W1963522904 hasConcept C2781092963 @default.
• W1963522904 hasConcept C2909370928 @default.
• W1963522904 hasConcept C2993390227 @default.
• W1963522904 hasConcept C49453240 @default.
• W1963522904 hasConcept C64943373 @default.
• W1963522904 hasConcept C71924100 @default.
• W1963522904 hasConcept C86132830 @default.
• W1963522904 hasConcept C98274493 @default.
• W1963522904 hasConceptScore W1963522904C118487528 @default.
• W1963522904 hasConceptScore W1963522904C121332964 @default.
• W1963522904 hasConceptScore W1963522904C126322002 @default.
• W1963522904 hasConceptScore W1963522904C134018914 @default.
• W1963522904 hasConceptScore W1963522904C141071460 @default.
• W1963522904 hasConceptScore W1963522904C153294291 @default.
• W1963522904 hasConceptScore W1963522904C185592680 @default.
• W1963522904 hasConceptScore W1963522904C2775944032 @default.
• W1963522904 hasConceptScore W1963522904C2776740260 @default.
• W1963522904 hasConceptScore W1963522904C2779904517 @default.
• W1963522904 hasConceptScore W1963522904C2780664492 @default.
• W1963522904 hasConceptScore W1963522904C2781092963 @default.
• W1963522904 hasConceptScore W1963522904C2909370928 @default.
• W1963522904 hasConceptScore W1963522904C2993390227 @default.
• W1963522904 hasConceptScore W1963522904C49453240 @default.
• W1963522904 hasConceptScore W1963522904C64943373 @default.
• W1963522904 hasConceptScore W1963522904C71924100 @default.
• W1963522904 hasConceptScore W1963522904C86132830 @default.
• W1963522904 hasConceptScore W1963522904C98274493 @default.
• W1963522904 hasLocation W19635229041 @default.
• W1963522904 hasLocation W19635229042 @default.
• W1963522904 hasOpenAccess W1963522904 @default.
• W1963522904 hasPrimaryLocation W19635229041 @default.
• W1963522904 hasRelatedWork W149870652 @default.
• W1963522904 hasRelatedWork W1835699834 @default.

• next