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• W1963524610 abstract "Background. There is a lack of effective treatment for metastatic adenoid cystic carcinoma (ACC), a usually indolent tumor. We studied the efficacy of imatinib mesylate, a potent inhibitor of KIT tyrosine kinase, in patients with KIT-positive metastatic ACC. Methods. Five patients with lung metastasis were treated in a pilot study with imatinib 400 mg by mouth twice a day. Mutations of c-kit and platelet-derived growth factor receptor (PDGFR)-α in tumors from these patients were analyzed. Results. Disease progression was noted in three of five patients during the short treatment periods, ranging from 2 to 3 weeks. Three patients died of disease within 6 months. No detectable mutations were found in c-kit and PDGFR-α. Conclusion. We observed an unexpected high progression rate of metastatic ACC within short periods during imatinib treatment. Use of imatinib to treat cancers without c-kit or PDGFR-α mutation should be approached with caution. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005" @default.
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• W1963524610 date "2005-12-01" @default.
• W1963524610 modified "2023-10-18" @default.
• W1963524610 title "Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate" @default.
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• W1963524610 doi "https://doi.org/10.1002/hed.20274" @default.
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