Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963526062> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1963526062 endingPage "950" @default.
- W1963526062 startingPage "943" @default.
- W1963526062 abstract "The oiling out and crystallization of a pharmaceutical compound from a water−ethanol mixture has been studied using a range of in-line process analytical techniques in order to more fully understand the phenomenon and build in control of its crystallization. Mechanistically, oiling out was found to follow a number of steps. It was shown that, in a well-mixed jacketed vessel, the small oil droplets formed on cooling a supersaturated solution grew and then coalesced into larger droplets, which subsequently crystallized. Cooling a static supersaturated solution of the compound resulted in two liquid layers, which if undisturbed were relatively stable. Chromatographic analysis of these layers showed that they contained each of the components, but in different amounts, and that crystallization occurred in the compound rich phase. In situ measurements showed that the temperature−solubility and the cloud point curve were well separated at lower temperatures but merged at higher temperatures. Identification of a metastable zone allowed a seeding strategy to be pursued, and by using a simple factorial experimental design, conditions that eliminated the oiling of the compound were determined." @default.
- W1963526062 created "2016-06-24" @default.
- W1963526062 creator A5048424706 @default.
- W1963526062 creator A5089203079 @default.
- W1963526062 date "2005-10-28" @default.
- W1963526062 modified "2023-09-25" @default.
- W1963526062 title "An In-Line Study of Oiling Out and Crystallization" @default.
- W1963526062 cites W1963993938 @default.
- W1963526062 cites W1968433538 @default.
- W1963526062 cites W1973350855 @default.
- W1963526062 cites W1980439193 @default.
- W1963526062 cites W1982789782 @default.
- W1963526062 cites W1993420071 @default.
- W1963526062 cites W2013955892 @default.
- W1963526062 cites W2031546022 @default.
- W1963526062 cites W2038367854 @default.
- W1963526062 cites W2048421236 @default.
- W1963526062 cites W2049057219 @default.
- W1963526062 cites W2062769921 @default.
- W1963526062 cites W2062830178 @default.
- W1963526062 cites W2070108162 @default.
- W1963526062 cites W2078518526 @default.
- W1963526062 cites W2081432759 @default.
- W1963526062 cites W2081622845 @default.
- W1963526062 cites W2084145400 @default.
- W1963526062 cites W2086809696 @default.
- W1963526062 cites W2091669252 @default.
- W1963526062 cites W2119919802 @default.
- W1963526062 cites W2148453484 @default.
- W1963526062 doi "https://doi.org/10.1021/op050107c" @default.
- W1963526062 hasPublicationYear "2005" @default.
- W1963526062 type Work @default.
- W1963526062 sameAs 1963526062 @default.
- W1963526062 citedByCount "92" @default.
- W1963526062 countsByYear W19635260622012 @default.
- W1963526062 countsByYear W19635260622013 @default.
- W1963526062 countsByYear W19635260622014 @default.
- W1963526062 countsByYear W19635260622015 @default.
- W1963526062 countsByYear W19635260622016 @default.
- W1963526062 countsByYear W19635260622017 @default.
- W1963526062 countsByYear W19635260622018 @default.
- W1963526062 countsByYear W19635260622019 @default.
- W1963526062 countsByYear W19635260622020 @default.
- W1963526062 countsByYear W19635260622021 @default.
- W1963526062 countsByYear W19635260622022 @default.
- W1963526062 countsByYear W19635260622023 @default.
- W1963526062 crossrefType "journal-article" @default.
- W1963526062 hasAuthorship W1963526062A5048424706 @default.
- W1963526062 hasAuthorship W1963526062A5089203079 @default.
- W1963526062 hasConcept C113196181 @default.
- W1963526062 hasConcept C121332964 @default.
- W1963526062 hasConcept C127413603 @default.
- W1963526062 hasConcept C155574463 @default.
- W1963526062 hasConcept C178790620 @default.
- W1963526062 hasConcept C185592680 @default.
- W1963526062 hasConcept C192562407 @default.
- W1963526062 hasConcept C200447597 @default.
- W1963526062 hasConcept C203036418 @default.
- W1963526062 hasConcept C36248471 @default.
- W1963526062 hasConcept C42360764 @default.
- W1963526062 hasConcept C43617362 @default.
- W1963526062 hasConcept C44280652 @default.
- W1963526062 hasConcept C89464430 @default.
- W1963526062 hasConcept C97355855 @default.
- W1963526062 hasConceptScore W1963526062C113196181 @default.
- W1963526062 hasConceptScore W1963526062C121332964 @default.
- W1963526062 hasConceptScore W1963526062C127413603 @default.
- W1963526062 hasConceptScore W1963526062C155574463 @default.
- W1963526062 hasConceptScore W1963526062C178790620 @default.
- W1963526062 hasConceptScore W1963526062C185592680 @default.
- W1963526062 hasConceptScore W1963526062C192562407 @default.
- W1963526062 hasConceptScore W1963526062C200447597 @default.
- W1963526062 hasConceptScore W1963526062C203036418 @default.
- W1963526062 hasConceptScore W1963526062C36248471 @default.
- W1963526062 hasConceptScore W1963526062C42360764 @default.
- W1963526062 hasConceptScore W1963526062C43617362 @default.
- W1963526062 hasConceptScore W1963526062C44280652 @default.
- W1963526062 hasConceptScore W1963526062C89464430 @default.
- W1963526062 hasConceptScore W1963526062C97355855 @default.
- W1963526062 hasIssue "6" @default.
- W1963526062 hasLocation W19635260621 @default.
- W1963526062 hasOpenAccess W1963526062 @default.
- W1963526062 hasPrimaryLocation W19635260621 @default.
- W1963526062 hasRelatedWork W1481179641 @default.
- W1963526062 hasRelatedWork W2041208916 @default.
- W1963526062 hasRelatedWork W2052034920 @default.
- W1963526062 hasRelatedWork W2057605102 @default.
- W1963526062 hasRelatedWork W2066372970 @default.
- W1963526062 hasRelatedWork W2158727649 @default.
- W1963526062 hasRelatedWork W2331076105 @default.
- W1963526062 hasRelatedWork W2388501402 @default.
- W1963526062 hasRelatedWork W2581587783 @default.
- W1963526062 hasRelatedWork W3143984554 @default.
- W1963526062 hasVolume "9" @default.
- W1963526062 isParatext "false" @default.
- W1963526062 isRetracted "false" @default.
- W1963526062 magId "1963526062" @default.
- W1963526062 workType "article" @default.