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- W1963526316 abstract "The ANKS1A gene product, also known as Odin, was first identified as a tyrosine-phosphorylated component of the epidermal growth factor receptor network. Here we show that Odin functions as an effector of EGFR recycling. In EGF-stimulated HEK293 cells tyrosine phosphorylation of Odin was induced prior to EGFR internalization and independent of EGFR-to-ERK signaling. Over-expression of Odin increased EGF-induced EGFR trafficking to recycling endosomes and recycling back to the cell surface, and decreased trafficking to lysosomes and degradation. Conversely, Odin knockdown in both HEK293 and the non-small cell lung carcinoma line RVH6849, which expresses roughly 10-fold more EGF receptors than HEK293, caused decreased EGFR recycling and accelerated trafficking to the lysosome and degradation. By governing the endocytic fate of internalized receptors, Odin may provide a layer of regulation that enables cells to contend with receptor cell densities and ligand concentration gradients that are physiologically and pathologically highly variable." @default.
- W1963526316 created "2016-06-24" @default.
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- W1963526316 date "2013-06-25" @default.
- W1963526316 modified "2023-10-16" @default.
- W1963526316 title "Odin (ANKS1A) Modulates EGF Receptor Recycling and Stability" @default.
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- W1963526316 doi "https://doi.org/10.1371/journal.pone.0064817" @default.
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