FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963526785> ?p ?o ?g. }

• W1963526785 endingPage "573" @default.
• W1963526785 startingPage "564" @default.
• W1963526785 abstract "Objective: There are conflicting reports of adverse HIV-associated alterations in white matter integrity as measured by diffusion tensor imaging (DTI). We sought to address these conflicting reports by assessing, on a voxel-by-voxel basis, HIV-associated regional changes in radiologically defined normal-appearing white matter (NAWM) integrity using high-resolution DTI. Methods: 30 HIV-seropositive (SP) and 30 HIV-seronegative (SN) nondemented, community-dwelling participants underwent DTI to derive whole-brain measures of white matter integrity (fractional anisotropy [FA] and mean diffusivity [MD]). For each participant, the white matter T2 volume was thresholded to remove regions of abnormal signal, resulting in a NAWM mask, which was then applied to the FA and MD volumes to extract voxel-wise NAWM measures of white matter integrity. Voxel-wise group comparisons of FA and MD were conducted (P < 0.005, extent threshold 5 voxels) while controlling for age and substance-abuse history. Results: There were no significant differences between the groups for demographic or cognitive performance variables. Summary whole-brain measures of FA and MD were equivalent between the SP and SN samples. Among the SP sample, history of substance abuse was associated with significantly increased whole-brain NAWM MD, and coinfection with hepatitis C virus (HCV) was associated with a trend for increased MD. Correlations between whole-brain NAWM FA and MD with cognitive performance measures were not significant. Regional analyses of DTI measures revealed variable differences in NAWM FA in the SP sample, with findings of both decreased and increased FA. Differences in NAWM MD were more consistent, with widespread increases noted in the SP sample compared to the SN sample. Eight of the 10 regions displaying significantly increased FA in the SP sample were also found to have significantly increased MD compared to the SN sample. Conclusions: Decreased white matter integrity is present even in radiologically defined NAWM in nondemented, community-dwelling patients with HIV. The decrease in NAWM integrity is best seen in increases in MD, a measure of generalized tissue breakdown. Indications of NAWM axonal integrity (FA) present a more complicated picture, with both decreased FA and increased FA in the SP sample. Our findings of variable HIV-associated FA changes in NAWM may account for previous conflicting reports of changes in DTI parameters in this population. The results of our study suggest that HIV infection contributes to variable changes in DTI values, reflecting both direct loss of axonal integrity and a loss of complexity to the underlying axonal matrix." @default.
• W1963526785 created "2016-06-24" @default.
• W1963526785 creator A5006950602 @default.
• W1963526785 creator A5041037504 @default.
• W1963526785 creator A5042372640 @default.
• W1963526785 creator A5048283695 @default.
• W1963526785 creator A5050597471 @default.
• W1963526785 creator A5056482539 @default.
• W1963526785 creator A5057264019 @default.
• W1963526785 creator A5067847718 @default.
• W1963526785 creator A5069469923 @default.
• W1963526785 date "2007-12-15" @default.
• W1963526785 modified "2023-09-27" @default.
• W1963526785 title "HIV-Associated Alterations in Normal-Appearing White Matter" @default.
• W1963526785 cites W1847168837 @default.
• W1963526785 cites W1964802316 @default.
• W1963526785 cites W1966352501 @default.
• W1963526785 cites W1970358275 @default.
• W1963526785 cites W1973653978 @default.
• W1963526785 cites W1978949387 @default.
• W1963526785 cites W1980267007 @default.
• W1963526785 cites W1980788503 @default.
• W1963526785 cites W1981212164 @default.
• W1963526785 cites W1981224949 @default.
• W1963526785 cites W1983112713 @default.
• W1963526785 cites W1983139353 @default.
• W1963526785 cites W1984362099 @default.
• W1963526785 cites W1990131415 @default.
• W1963526785 cites W1992863772 @default.
• W1963526785 cites W2007444843 @default.
• W1963526785 cites W2008158562 @default.
• W1963526785 cites W2008258216 @default.
• W1963526785 cites W2013639086 @default.
• W1963526785 cites W2017026587 @default.
• W1963526785 cites W2022530159 @default.
• W1963526785 cites W2024442062 @default.
• W1963526785 cites W2027580727 @default.
• W1963526785 cites W2027864333 @default.
• W1963526785 cites W2030624155 @default.
• W1963526785 cites W2037303541 @default.
• W1963526785 cites W2037476840 @default.
• W1963526785 cites W2043024063 @default.
• W1963526785 cites W2043523440 @default.
• W1963526785 cites W2046132588 @default.
• W1963526785 cites W2047384740 @default.
• W1963526785 cites W2048406048 @default.
• W1963526785 cites W2049863380 @default.
• W1963526785 cites W2050660837 @default.
• W1963526785 cites W2056473993 @default.
• W1963526785 cites W2060467098 @default.
• W1963526785 cites W2063349935 @default.
• W1963526785 cites W2063955495 @default.
• W1963526785 cites W2066454193 @default.
• W1963526785 cites W2067478652 @default.
• W1963526785 cites W2069166243 @default.
• W1963526785 cites W2071878436 @default.
• W1963526785 cites W2073804933 @default.
• W1963526785 cites W2076580408 @default.
• W1963526785 cites W2093554933 @default.
• W1963526785 cites W2094974164 @default.
• W1963526785 cites W2099556941 @default.
• W1963526785 cites W2100641133 @default.
• W1963526785 cites W2111446187 @default.
• W1963526785 cites W2112015708 @default.
• W1963526785 cites W2115424422 @default.
• W1963526785 cites W2118421222 @default.
• W1963526785 cites W2120357670 @default.
• W1963526785 cites W2120445087 @default.
• W1963526785 cites W2123261378 @default.
• W1963526785 cites W2127267426 @default.
• W1963526785 cites W2128776571 @default.
• W1963526785 cites W2132249051 @default.
• W1963526785 cites W2132968845 @default.
• W1963526785 cites W2137231705 @default.
• W1963526785 cites W2139158372 @default.
• W1963526785 cites W2156945570 @default.
• W1963526785 cites W2169005238 @default.
• W1963526785 cites W2169366712 @default.
• W1963526785 cites W2169428430 @default.
• W1963526785 doi "https://doi.org/10.1097/qai.0b013e318159d807" @default.
• W1963526785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18193498" @default.
• W1963526785 hasPublicationYear "2007" @default.
• W1963526785 type Work @default.
• W1963526785 sameAs 1963526785 @default.
• W1963526785 citedByCount "72" @default.
• W1963526785 countsByYear W19635267852012 @default.
• W1963526785 countsByYear W19635267852013 @default.
• W1963526785 countsByYear W19635267852014 @default.
• W1963526785 countsByYear W19635267852015 @default.
• W1963526785 countsByYear W19635267852016 @default.
• W1963526785 countsByYear W19635267852017 @default.
• W1963526785 countsByYear W19635267852018 @default.
• W1963526785 countsByYear W19635267852019 @default.
• W1963526785 countsByYear W19635267852020 @default.
• W1963526785 countsByYear W19635267852021 @default.
• W1963526785 countsByYear W19635267852022 @default.
• W1963526785 countsByYear W19635267852023 @default.
• W1963526785 crossrefType "journal-article" @default.

• next