FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963526834> ?p ?o ?g. }

• W1963526834 endingPage "1494" @default.
• W1963526834 startingPage "1483" @default.
• W1963526834 abstract "Combination of two or more therapeutic strategies with different mechanisms can cooperatively prohibit cancer development. Combination of chemotherapy and small interfering RNA (siRNA)-based therapy represents an example of this approach. Hypothesizing that the chemotherapeutic drug and the siRNA should be simultaneously delivered to the same tumoral cell to exert their synergistic effect, the development of delivery systems that can efficiently encapsulate two drugs and successfully deliver payloads to targeted sites via systemic administration has proven to be challenging. Here, we demonstrate an innovative two-in-one micelleplex approach based on micellar nanoparticles of a biodegradable triblock copolymer poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-aminoethyl ethylene phosphate) to systemically deliver the siRNA and chemotherapeutic drug. We show clear evidence that the micelleplex is capable of delivering siRNA and paclitaxel simultaneously to the same tumoral cells both in vitro and in vivo. We further demonstrate that systemic administration of the micelleplex carrying polo-like kinase 1 (Plk1) specific siRNA and paclitaxel can induce a synergistic tumor suppression effect in the MDA-MB-435s xenograft murine model, requiring a thousand-fold less paclitaxel than needed for paclitaxel monotherapy delivered by the micelleplex and without activation of the innate immune response or generation of carrier-associated toxicity." @default.
• W1963526834 created "2016-06-24" @default.
• W1963526834 creator A5010578515 @default.
• W1963526834 creator A5016460712 @default.
• W1963526834 creator A5021387235 @default.
• W1963526834 creator A5023294622 @default.
• W1963526834 creator A5037094854 @default.
• W1963526834 creator A5041932563 @default.
• W1963526834 creator A5043257116 @default.
• W1963526834 creator A5050822671 @default.
• W1963526834 creator A5061248240 @default.
• W1963526834 creator A5079785653 @default.
• W1963526834 date "2011-01-04" @default.
• W1963526834 modified "2023-10-14" @default.
• W1963526834 title "Simultaneous Delivery of siRNA and Paclitaxel <i>via</i> a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression" @default.
• W1963526834 cites W1658047882 @default.
• W1963526834 cites W1969313893 @default.
• W1963526834 cites W1975776530 @default.
• W1963526834 cites W1975912702 @default.
• W1963526834 cites W1978932462 @default.
• W1963526834 cites W1983718760 @default.
• W1963526834 cites W1989611595 @default.
• W1963526834 cites W1997792812 @default.
• W1963526834 cites W2000691433 @default.
• W1963526834 cites W2003006200 @default.
• W1963526834 cites W2005082473 @default.
• W1963526834 cites W2008171455 @default.
• W1963526834 cites W2012821120 @default.
• W1963526834 cites W2013270956 @default.
• W1963526834 cites W2014509855 @default.
• W1963526834 cites W2015507005 @default.
• W1963526834 cites W2016918995 @default.
• W1963526834 cites W2020411912 @default.
• W1963526834 cites W2024303172 @default.
• W1963526834 cites W2025540821 @default.
• W1963526834 cites W2027954222 @default.
• W1963526834 cites W2032903792 @default.
• W1963526834 cites W2034701758 @default.
• W1963526834 cites W2048369172 @default.
• W1963526834 cites W2057256078 @default.
• W1963526834 cites W2057848113 @default.
• W1963526834 cites W2063038780 @default.
• W1963526834 cites W2077945404 @default.
• W1963526834 cites W2083249633 @default.
• W1963526834 cites W2089150369 @default.
• W1963526834 cites W2095151181 @default.
• W1963526834 cites W2115161796 @default.
• W1963526834 cites W2120421571 @default.
• W1963526834 cites W2139898001 @default.
• W1963526834 cites W2140093304 @default.
• W1963526834 cites W2149147994 @default.
• W1963526834 cites W2150702593 @default.
• W1963526834 doi "https://doi.org/10.1021/nn103349h" @default.
• W1963526834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21204585" @default.
• W1963526834 hasPublicationYear "2011" @default.
• W1963526834 type Work @default.
• W1963526834 sameAs 1963526834 @default.
• W1963526834 citedByCount "377" @default.
• W1963526834 countsByYear W19635268342012 @default.
• W1963526834 countsByYear W19635268342013 @default.
• W1963526834 countsByYear W19635268342014 @default.
• W1963526834 countsByYear W19635268342015 @default.
• W1963526834 countsByYear W19635268342016 @default.
• W1963526834 countsByYear W19635268342017 @default.
• W1963526834 countsByYear W19635268342018 @default.
• W1963526834 countsByYear W19635268342019 @default.
• W1963526834 countsByYear W19635268342020 @default.
• W1963526834 countsByYear W19635268342021 @default.
• W1963526834 countsByYear W19635268342022 @default.
• W1963526834 countsByYear W19635268342023 @default.
• W1963526834 crossrefType "journal-article" @default.
• W1963526834 hasAuthorship W1963526834A5010578515 @default.
• W1963526834 hasAuthorship W1963526834A5016460712 @default.
• W1963526834 hasAuthorship W1963526834A5021387235 @default.
• W1963526834 hasAuthorship W1963526834A5023294622 @default.
• W1963526834 hasAuthorship W1963526834A5037094854 @default.
• W1963526834 hasAuthorship W1963526834A5041932563 @default.
• W1963526834 hasAuthorship W1963526834A5043257116 @default.
• W1963526834 hasAuthorship W1963526834A5050822671 @default.
• W1963526834 hasAuthorship W1963526834A5061248240 @default.
• W1963526834 hasAuthorship W1963526834A5079785653 @default.
• W1963526834 hasConcept C104317684 @default.
• W1963526834 hasConcept C121608353 @default.
• W1963526834 hasConcept C126322002 @default.
• W1963526834 hasConcept C150903083 @default.
• W1963526834 hasConcept C166703698 @default.
• W1963526834 hasConcept C171250308 @default.
• W1963526834 hasConcept C178790620 @default.
• W1963526834 hasConcept C185592680 @default.
• W1963526834 hasConcept C192562407 @default.
• W1963526834 hasConcept C202751555 @default.
• W1963526834 hasConcept C207001950 @default.
• W1963526834 hasConcept C22615655 @default.
• W1963526834 hasConcept C25938499 @default.
• W1963526834 hasConcept C2777292972 @default.
• W1963526834 hasConcept C2777516009 @default.
• W1963526834 hasConcept C2779820397 @default.
• W1963526834 hasConcept C2780035454 @default.

• next