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- W1963526905 abstract "1. OBSERVATIONS ON THE INFLUENCE OF CORTISONE ON CUTANEOUS IRRITATION AND SENSITIZATION INDUCED BY VARIOUS CHEMICAL COMPOUNDS It has long been known that there is some relationship between immune reactions and the function of the adrenal cortex. Thus, Wolfrom and Zwemer (1935) (1) have shown that adrenalectomized animals are more sensitive to anaphylactic shock than are normal animals, and that injection of adrenal cortex hormone increases the resistance to anaphylactic shock. It has not been possible, however, to obtain the same effect with ACTH or cortisone (2). Dougherty, Chase and White (3, 4) have found that injections of ACTH or adrenal cortex hormone into immunized animals cause a marked destruction of their lymphocytes and an increase in the concentration of gamma globulin and antibodies in their blood. These experiments have stimulated an increased interest in the antibody mechanism, and a number of papers concerning this problem have been published. The results vary in many respects. Thus, for example, Fischel, LeMay and Kabat (5) could not demonstrate any increase in the antibody concentration after treatment with cortisone, while Bj0rneboe, Fischel and Stoerk (6), as well as Germuth and Ottinger (7) found a decrease." @default.
- W1963526905 created "2016-06-24" @default.
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- W1963526905 date "1952-01-01" @default.
- W1963526905 modified "2023-09-23" @default.
- W1963526905 title "Some Endocrine Aspects of Skin Sensitization and Primary Irritation" @default.
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- W1963526905 doi "https://doi.org/10.1038/jid.1952.4" @default.
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