FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963526972> ?p ?o ?g. }

• W1963526972 endingPage "418" @default.
• W1963526972 startingPage "412" @default.
• W1963526972 abstract "The mitogenic and vasoconstrictive properties of the vascular system are attributed to endothelin‑1 (ET‑1). ET-1 serum concentration increases in a number of pathological conditions, particularly in those associated with blood vessel constriction. ET‑1 is also associated with the underlying pathomechanisms of primary pulmonary hypertension, arterial hypertension and eclampsia. The aim of this study was to compare the vasodilating properties of selected phosphodiesterase (PDE) inhibitors and celecoxib in human mesenteric arteries constricted with ET‑1, and investigate the role of the endothelium in relaxation. Perfused human mesenteric arteries were collected and stored under the same conditions as organs for transplantation. The mesenteric arteries (with and without the endothelium) were constricted by the addition of ET‑1 and treated with one of the following: sildenafil (PDE5 inhibitor), zaprinast (PDE5 and 6 inhibitor), rolipram (PDE4 inhibitor) and celecoxib [cyclooxygenase‑2 (COX‑2) inhibitor]. Based on the observed changes of the perfusion pressure, concentration response curves (CRCs) were prepared for the respective inhibitors and the EC50 (concentration causing an effect equal to half of the maximum effect), pD2 (negative common logarithm of EC50) and relative potency (RP) were calculated. The results suggested that all the inhibitors triggered a concentration‑dependent decrease in the perfusion pressure in isolated human superior mesenteric arteries with endothelium constricted by the addition of ET‑1. In the arteries without endothelium, CRCs for celecoxib and rolipram were shifted to the right without a significant decrease in the maximum dilating effect. Moreover, CRCs for sildenafil and zaprinast were shifted to the right with a simultaneous significant decrease in the maximum dilating effect and with an increased inclination angle in reference to the concentration axis. In the presence of the endothelium, all of the evaluated PDE inhibitors, as well as celecoxib, reduced the reactivity of the mesenteric arteries caused by ET‑1. Sildenafil indicated the lowest efficacy in the presence of the endothelium, but showed a higher potency compared to that of the other compounds. Removing the endothelium significantly reduced the vasodilating efficacy of PDE5 and 6 inhibitors and a statistically significant influence on the vasodilating efficacy of PDE4 inhibitor and celecoxib was observed. The high vasorelaxing efficacy of celecoxib at the background of the PDE inhibitors was observed, not only in the presence, but also in the absence of the endothelium and may be evidence for the relaxation induced by this COX‑2 inhibitor in the cAMP‑ and cGMP‑dependent pathways." @default.
• W1963526972 created "2016-06-24" @default.
• W1963526972 creator A5015212397 @default.
• W1963526972 creator A5024271749 @default.
• W1963526972 creator A5028858508 @default.
• W1963526972 creator A5032111845 @default.
• W1963526972 creator A5060104907 @default.
• W1963526972 creator A5066002214 @default.
• W1963526972 creator A5078345329 @default.
• W1963526972 date "2014-01-29" @default.
• W1963526972 modified "2023-10-04" @default.
• W1963526972 title "Influence of celecoxib on the vasodilating properties of human mesenteric arteries constricted with endothelin-1" @default.
• W1963526972 cites W1760947721 @default.
• W1963526972 cites W1780627874 @default.
• W1963526972 cites W1970022838 @default.
• W1963526972 cites W1978033197 @default.
• W1963526972 cites W1978165458 @default.
• W1963526972 cites W1980268785 @default.
• W1963526972 cites W1988860992 @default.
• W1963526972 cites W1991110402 @default.
• W1963526972 cites W1995989576 @default.
• W1963526972 cites W1997868972 @default.
• W1963526972 cites W2002178040 @default.
• W1963526972 cites W2003016773 @default.
• W1963526972 cites W2006259818 @default.
• W1963526972 cites W2012801178 @default.
• W1963526972 cites W2018716226 @default.
• W1963526972 cites W2026403696 @default.
• W1963526972 cites W2027140482 @default.
• W1963526972 cites W2053952969 @default.
• W1963526972 cites W2096198355 @default.
• W1963526972 cites W2096874183 @default.
• W1963526972 cites W2100749543 @default.
• W1963526972 cites W2105297145 @default.
• W1963526972 cites W2109639347 @default.
• W1963526972 cites W2118462346 @default.
• W1963526972 cites W2120810383 @default.
• W1963526972 cites W2121619203 @default.
• W1963526972 cites W2129333373 @default.
• W1963526972 cites W2131189712 @default.
• W1963526972 cites W2138373583 @default.
• W1963526972 cites W2138742704 @default.
• W1963526972 cites W2139776244 @default.
• W1963526972 cites W2148410073 @default.
• W1963526972 cites W2158131645 @default.
• W1963526972 cites W2158968701 @default.
• W1963526972 cites W2160307156 @default.
• W1963526972 cites W2171971497 @default.
• W1963526972 cites W2584655285 @default.
• W1963526972 doi "https://doi.org/10.3892/br.2014.233" @default.
• W1963526972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3990212" @default.
• W1963526972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24748985" @default.
• W1963526972 hasPublicationYear "2014" @default.
• W1963526972 type Work @default.
• W1963526972 sameAs 1963526972 @default.
• W1963526972 citedByCount "4" @default.
• W1963526972 countsByYear W19635269722017 @default.
• W1963526972 countsByYear W19635269722023 @default.
• W1963526972 crossrefType "journal-article" @default.
• W1963526972 hasAuthorship W1963526972A5015212397 @default.
• W1963526972 hasAuthorship W1963526972A5024271749 @default.
• W1963526972 hasAuthorship W1963526972A5028858508 @default.
• W1963526972 hasAuthorship W1963526972A5032111845 @default.
• W1963526972 hasAuthorship W1963526972A5060104907 @default.
• W1963526972 hasAuthorship W1963526972A5066002214 @default.
• W1963526972 hasAuthorship W1963526972A5078345329 @default.
• W1963526972 hasBestOaLocation W19635269721 @default.
• W1963526972 hasConcept C120770815 @default.
• W1963526972 hasConcept C126322002 @default.
• W1963526972 hasConcept C134018914 @default.
• W1963526972 hasConcept C144980905 @default.
• W1963526972 hasConcept C146957229 @default.
• W1963526972 hasConcept C170493617 @default.
• W1963526972 hasConcept C173803235 @default.
• W1963526972 hasConcept C2776467144 @default.
• W1963526972 hasConcept C2776820930 @default.
• W1963526972 hasConcept C2776846068 @default.
• W1963526972 hasConcept C2776992346 @default.
• W1963526972 hasConcept C2779961880 @default.
• W1963526972 hasConcept C2780771799 @default.
• W1963526972 hasConcept C42219234 @default.
• W1963526972 hasConcept C519581460 @default.
• W1963526972 hasConcept C71924100 @default.
• W1963526972 hasConcept C98274493 @default.
• W1963526972 hasConceptScore W1963526972C120770815 @default.
• W1963526972 hasConceptScore W1963526972C126322002 @default.
• W1963526972 hasConceptScore W1963526972C134018914 @default.
• W1963526972 hasConceptScore W1963526972C144980905 @default.
• W1963526972 hasConceptScore W1963526972C146957229 @default.
• W1963526972 hasConceptScore W1963526972C170493617 @default.
• W1963526972 hasConceptScore W1963526972C173803235 @default.
• W1963526972 hasConceptScore W1963526972C2776467144 @default.
• W1963526972 hasConceptScore W1963526972C2776820930 @default.
• W1963526972 hasConceptScore W1963526972C2776846068 @default.
• W1963526972 hasConceptScore W1963526972C2776992346 @default.
• W1963526972 hasConceptScore W1963526972C2779961880 @default.
• W1963526972 hasConceptScore W1963526972C2780771799 @default.
• W1963526972 hasConceptScore W1963526972C42219234 @default.

• next