Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963528029> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1963528029 endingPage "209" @default.
- W1963528029 startingPage "205" @default.
- W1963528029 abstract "Baicalin and baicalein, a flavone glucuronide and its aglycone, are bioactive constituents of Scutellariae Radix with various beneficial activities. We have characterized and compared the metabolic pharmacokinetics of baicalin and baicalein in rats. Baicalein was administered intravenously and orally to rats, and baicalin was orally administered. An HPLC method was used to determine the concentration of baicalein before and after hydrolysis using beta-glucuronidase/sulfatase. The pharmacokinetic parameters were calculated by using WINNONLIN. Unpaired Student's t-test was used for statistical comparison. The result showed that after intravenous administration of baicalein, 75.7% of the dose was circulating as its conjugated metabolites. After oral administration of baicalein, absorption of baicalein itself was negligible, whereas the glucuronides/sulfates of baicalein were predominant in the plasma. When compared with intravenous bolus administration with dose correction, the absolute absorption was 40%. When baicalin was administered orally, glucuronides and sulfates of baicalein were exclusively circulating in the plasma. The relative absorption for baicalin was 65% when compared with baicalein. Profound differences of serum profile and pharmacokinetics were observed between oral baicalein and baicalin. Baicalin demonstrated significantly later time to peak concentration (t(max)) and lower peak serum concentration (C(max)) of baicalein conjugated metabolites than baicalein, indicating baicalin was absorbed more slowly and to a lesser extent than baicalein." @default.
- W1963528029 created "2016-06-24" @default.
- W1963528029 creator A5016271707 @default.
- W1963528029 creator A5032282672 @default.
- W1963528029 creator A5047435191 @default.
- W1963528029 creator A5061470245 @default.
- W1963528029 creator A5073324646 @default.
- W1963528029 date "2003-02-01" @default.
- W1963528029 modified "2023-10-01" @default.
- W1963528029 title "Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats" @default.
- W1963528029 cites W1975672084 @default.
- W1963528029 cites W1977672191 @default.
- W1963528029 cites W1978000487 @default.
- W1963528029 cites W1992335800 @default.
- W1963528029 cites W2012702883 @default.
- W1963528029 cites W2017821395 @default.
- W1963528029 cites W2024105848 @default.
- W1963528029 cites W2034485827 @default.
- W1963528029 cites W2071213207 @default.
- W1963528029 cites W2080216734 @default.
- W1963528029 cites W2116255231 @default.
- W1963528029 cites W2122708593 @default.
- W1963528029 cites W2465522443 @default.
- W1963528029 doi "https://doi.org/10.1211/002235702522" @default.
- W1963528029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12631413" @default.
- W1963528029 hasPublicationYear "2003" @default.
- W1963528029 type Work @default.
- W1963528029 sameAs 1963528029 @default.
- W1963528029 citedByCount "165" @default.
- W1963528029 countsByYear W19635280292012 @default.
- W1963528029 countsByYear W19635280292013 @default.
- W1963528029 countsByYear W19635280292014 @default.
- W1963528029 countsByYear W19635280292015 @default.
- W1963528029 countsByYear W19635280292016 @default.
- W1963528029 countsByYear W19635280292017 @default.
- W1963528029 countsByYear W19635280292018 @default.
- W1963528029 countsByYear W19635280292019 @default.
- W1963528029 countsByYear W19635280292020 @default.
- W1963528029 countsByYear W19635280292021 @default.
- W1963528029 countsByYear W19635280292022 @default.
- W1963528029 countsByYear W19635280292023 @default.
- W1963528029 crossrefType "journal-article" @default.
- W1963528029 hasAuthorship W1963528029A5016271707 @default.
- W1963528029 hasAuthorship W1963528029A5032282672 @default.
- W1963528029 hasAuthorship W1963528029A5047435191 @default.
- W1963528029 hasAuthorship W1963528029A5061470245 @default.
- W1963528029 hasAuthorship W1963528029A5073324646 @default.
- W1963528029 hasBestOaLocation W19635280291 @default.
- W1963528029 hasConcept C112705442 @default.
- W1963528029 hasConcept C125287762 @default.
- W1963528029 hasConcept C159985019 @default.
- W1963528029 hasConcept C179998833 @default.
- W1963528029 hasConcept C185592680 @default.
- W1963528029 hasConcept C192562407 @default.
- W1963528029 hasConcept C2777056448 @default.
- W1963528029 hasConcept C2777477808 @default.
- W1963528029 hasConcept C2779186261 @default.
- W1963528029 hasConcept C2780113650 @default.
- W1963528029 hasConcept C2781466915 @default.
- W1963528029 hasConcept C43617362 @default.
- W1963528029 hasConcept C55493867 @default.
- W1963528029 hasConcept C71924100 @default.
- W1963528029 hasConcept C98274493 @default.
- W1963528029 hasConceptScore W1963528029C112705442 @default.
- W1963528029 hasConceptScore W1963528029C125287762 @default.
- W1963528029 hasConceptScore W1963528029C159985019 @default.
- W1963528029 hasConceptScore W1963528029C179998833 @default.
- W1963528029 hasConceptScore W1963528029C185592680 @default.
- W1963528029 hasConceptScore W1963528029C192562407 @default.
- W1963528029 hasConceptScore W1963528029C2777056448 @default.
- W1963528029 hasConceptScore W1963528029C2777477808 @default.
- W1963528029 hasConceptScore W1963528029C2779186261 @default.
- W1963528029 hasConceptScore W1963528029C2780113650 @default.
- W1963528029 hasConceptScore W1963528029C2781466915 @default.
- W1963528029 hasConceptScore W1963528029C43617362 @default.
- W1963528029 hasConceptScore W1963528029C55493867 @default.
- W1963528029 hasConceptScore W1963528029C71924100 @default.
- W1963528029 hasConceptScore W1963528029C98274493 @default.
- W1963528029 hasIssue "2" @default.
- W1963528029 hasLocation W19635280291 @default.
- W1963528029 hasLocation W19635280292 @default.
- W1963528029 hasOpenAccess W1963528029 @default.
- W1963528029 hasPrimaryLocation W19635280291 @default.
- W1963528029 hasRelatedWork W1963790044 @default.
- W1963528029 hasRelatedWork W1970311735 @default.
- W1963528029 hasRelatedWork W2014024345 @default.
- W1963528029 hasRelatedWork W2056938528 @default.
- W1963528029 hasRelatedWork W2079185888 @default.
- W1963528029 hasRelatedWork W2087953688 @default.
- W1963528029 hasRelatedWork W2088945339 @default.
- W1963528029 hasRelatedWork W2365654625 @default.
- W1963528029 hasRelatedWork W2386049531 @default.
- W1963528029 hasRelatedWork W2391770335 @default.
- W1963528029 hasVolume "55" @default.
- W1963528029 isParatext "false" @default.
- W1963528029 isRetracted "false" @default.
- W1963528029 magId "1963528029" @default.
- W1963528029 workType "article" @default.