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- W1963530961 abstract "In pyramidal cortical cells, high-voltage-activated Ca2− currents affect seizure propagation and the release of excitatory amino acids at the corticostriatal axon terminals. The new antiepileptic drug lamotrigine (Lamictal) produced a large and dose-dependent inhibition of high-voltage-activated Ca2+ currents (IC50 = 12.3 μM) in rat cortical neurons. This action was not blocked by the dihydropyridine receptor antagonist nifedipine; instead, the response was blocked by the concomitant application of the N-type Ca2+ channel blocker, ω-conotoxin GVIA (1–3 μM) and the P-type Ca2+ channel blocker, ω-agatoxin-IVA (20–100 nM). These findings demonstrate that lamotrigine, at therapeutic doses, is capable of modulating the Ca2+ conductances involved in excitatory amino acid release in the corticostriatal pathway, partially explaining lamotrigine usefulness in the therapy of epilepsy as well as in the treatment of excitatory amino acid-induced neurotoxicity." @default.
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- W1963530961 date "1996-06-01" @default.
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- W1963530961 title "Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications" @default.
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- W1963530961 doi "https://doi.org/10.1016/0014-2999(96)00265-8" @default.
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