Matches in SemOpenAlex for { <https://semopenalex.org/work/W1963531337> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1963531337 endingPage "594" @default.
- W1963531337 startingPage "585" @default.
- W1963531337 abstract "Background Inhaled perfluorohexan vapor has been shown to improve gas exchange and pulmonary mechanics in oleic acid- and ventilator-induced lung injury. However, in the clinical setting, lung injury frequently occurs in the context of systemic inflammation and consecutive lung injury, which may be induced experimentally by intravenous administration of endotoxin. The authors studied whether vaporized perfluorohexan is efficacious during endotoxin-induced lung injury in domestic pigs. Methods Twenty-two pigs (29 [23, 31] kg body weight [first, third interquartile]; tracheostomy) were anesthetized and mechanically ventilated. In the endotoxin (n = 8) and perfluorohexan groups (n = 7), we administered endotoxin of Escherichia coli 111:B4, 1 mg.kg . h for 1 h and 10 microg.kg.h for 5 h in consecutive order. In the perfluorohexan group, inhalation of the test drug was started 2 h 30 min after the start of the intravenous endotoxin and terminated after 30 min. In a control group (n=7), animals were instrumented and observed over time without further intervention. Oxygenation function was assessed from oxygen partial pressures (Po2, blood gases) and calculated shunt fraction. Respiratory compliance was calculated from airway pressure and tidal volume. Measurements were performed before and every hour during endotoxin infusion. Results After 6 h of endotoxin, gas exchange and pulmonary compliance were deteriorated in the endotoxin group (Pao2: 184 [114, 289] vs. 638 [615, 658] mmHg, pulmonary shunt fraction: 30 [23, 38] vs. 4 [3, 6]%, respiratory compliance: 12 [11, 14] vs. 22 [19, 23] ml/mbar; P < 0.05, endotoxin vs. control). Inhalation of vaporized perfluorohexan did not improve Pao 2 (107 [60, 221] mmHg), pulmonary shunt fraction (32 [26, 58]%), or respiratory compliance (14 [10, 17] ml/mbar) when compared with intravenous endotoxin (not significant, perfluorohexan vs. endotoxin). Conclusions Inhalation of vaporized perfluorohexan does not improve pulmonary gas exchange or respiratory compliance in endotoxin-induced porcine lung injury." @default.
- W1963531337 created "2016-06-24" @default.
- W1963531337 creator A5004771457 @default.
- W1963531337 creator A5013172550 @default.
- W1963531337 creator A5018218983 @default.
- W1963531337 creator A5031141271 @default.
- W1963531337 creator A5053243071 @default.
- W1963531337 creator A5063853029 @default.
- W1963531337 creator A5070079240 @default.
- W1963531337 creator A5074767732 @default.
- W1963531337 creator A5078635104 @default.
- W1963531337 date "2005-09-01" @default.
- W1963531337 modified "2023-09-27" @default.
- W1963531337 title "Effects of Perfluorohexan Vapor on Gas Exchange, Respiratory Mechanics, and Lung Histology in Pigs with Lung Injury after Endotoxin Infusion" @default.
- W1963531337 cites W1997640982 @default.
- W1963531337 cites W2006356492 @default.
- W1963531337 cites W2013087459 @default.
- W1963531337 cites W2022759011 @default.
- W1963531337 cites W2028072481 @default.
- W1963531337 cites W2059715348 @default.
- W1963531337 cites W2075650504 @default.
- W1963531337 cites W2076907782 @default.
- W1963531337 cites W2093852073 @default.
- W1963531337 cites W2111830288 @default.
- W1963531337 cites W2119848633 @default.
- W1963531337 cites W2131953296 @default.
- W1963531337 cites W2161328469 @default.
- W1963531337 cites W2413138806 @default.
- W1963531337 cites W3133207174 @default.
- W1963531337 doi "https://doi.org/10.1097/00000542-200509000-00022" @default.
- W1963531337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16129984" @default.
- W1963531337 hasPublicationYear "2005" @default.
- W1963531337 type Work @default.
- W1963531337 sameAs 1963531337 @default.
- W1963531337 citedByCount "7" @default.
- W1963531337 crossrefType "journal-article" @default.
- W1963531337 hasAuthorship W1963531337A5004771457 @default.
- W1963531337 hasAuthorship W1963531337A5013172550 @default.
- W1963531337 hasAuthorship W1963531337A5018218983 @default.
- W1963531337 hasAuthorship W1963531337A5031141271 @default.
- W1963531337 hasAuthorship W1963531337A5053243071 @default.
- W1963531337 hasAuthorship W1963531337A5063853029 @default.
- W1963531337 hasAuthorship W1963531337A5070079240 @default.
- W1963531337 hasAuthorship W1963531337A5074767732 @default.
- W1963531337 hasAuthorship W1963531337A5078635104 @default.
- W1963531337 hasBestOaLocation W19635313371 @default.
- W1963531337 hasConcept C126322002 @default.
- W1963531337 hasConcept C142724271 @default.
- W1963531337 hasConcept C151730666 @default.
- W1963531337 hasConcept C163498912 @default.
- W1963531337 hasConcept C2777714996 @default.
- W1963531337 hasConcept C2779343474 @default.
- W1963531337 hasConcept C42219234 @default.
- W1963531337 hasConcept C534529494 @default.
- W1963531337 hasConcept C71924100 @default.
- W1963531337 hasConcept C86803240 @default.
- W1963531337 hasConceptScore W1963531337C126322002 @default.
- W1963531337 hasConceptScore W1963531337C142724271 @default.
- W1963531337 hasConceptScore W1963531337C151730666 @default.
- W1963531337 hasConceptScore W1963531337C163498912 @default.
- W1963531337 hasConceptScore W1963531337C2777714996 @default.
- W1963531337 hasConceptScore W1963531337C2779343474 @default.
- W1963531337 hasConceptScore W1963531337C42219234 @default.
- W1963531337 hasConceptScore W1963531337C534529494 @default.
- W1963531337 hasConceptScore W1963531337C71924100 @default.
- W1963531337 hasConceptScore W1963531337C86803240 @default.
- W1963531337 hasIssue "3" @default.
- W1963531337 hasLocation W19635313371 @default.
- W1963531337 hasLocation W19635313372 @default.
- W1963531337 hasOpenAccess W1963531337 @default.
- W1963531337 hasPrimaryLocation W19635313371 @default.
- W1963531337 hasRelatedWork W1542936232 @default.
- W1963531337 hasRelatedWork W1995469802 @default.
- W1963531337 hasRelatedWork W2030774490 @default.
- W1963531337 hasRelatedWork W2047409163 @default.
- W1963531337 hasRelatedWork W2108335571 @default.
- W1963531337 hasRelatedWork W2218851808 @default.
- W1963531337 hasRelatedWork W2272303148 @default.
- W1963531337 hasRelatedWork W2606046120 @default.
- W1963531337 hasRelatedWork W2803009265 @default.
- W1963531337 hasRelatedWork W3145682372 @default.
- W1963531337 hasVolume "103" @default.
- W1963531337 isParatext "false" @default.
- W1963531337 isRetracted "false" @default.
- W1963531337 magId "1963531337" @default.
- W1963531337 workType "article" @default.